PKS and NRPS release mechanisms

Cyclopiazonic Acid Biosynthesis inAspergillussp.: Characterization of a Reductase-like R* Domain in Cyclopiazonate Synthetase That Forms and Releasescyclo-Acetoacetyl-l-tryptophan

(2009) Xinyu Liu et al.   BIOCHEMISTRY

A Thioesterase from an Iterative Fungal Polyketide Synthase Shows Macrocyclization and Cross Coupling Activity and May Play a Role in Controlling Iterative Cycling through Product Offloading

(2009) Meng Wang et al.   BIOCHEMISTRY

Crystal Structure of Baeyer−Villiger Monooxygenase MtmOIV, the Key Enzyme of the Mithramycin Biosynthetic Pathway,

(2009) Miranda P. Beam et al.   BIOCHEMISTRY

Analysis of the Indanomycin Biosynthetic Gene Cluster fromStreptomyces antibioticusNRRL 8167

(2009) Chaoxuan Li et al.   CHEMBIOCHEM

Physically Discrete β-Lactamase-Type Thioesterase Catalyzes Product Release in Atrochrysone Synthesis by Iterative Type I Polyketide Synthase

(2009) Takayoshi Awakawa et al.   CHEMISTRY & BIOLOGY

Unusual Chemistry in the Biosynthesis of the Antibiotic Chondrochlorens

(2009) Shwan Rachid et al.   CHEMISTRY & BIOLOGY

TioS T-TE - a prototypical thioesterase responsible for cyclodimerization of the quinoline- and quinoxaline-type class of chromodepsipeptides

(2009) Lars Robbel et al.   FEBS Journal

Structure and Catalytic Mechanism of the Thioesterase CalE7 in Enediyne Biosynthesis

(2009) Masayo Kotaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Production of Octaketide Polyenes by the Calicheamicin Polyketide Synthase CalE8: Implications for the Biosynthesis of Enediyne Core Structures

(2009) Katherine Belecki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A PLP-Dependent Polyketide Chain Releasing Mechanism in the Biosynthesis of Mycotoxin Fumonisins inFusarium verticillioides

(2009) Ryan Gerber et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Acyltransferase Mediated Polyketide Release from a Fungal Megasynthase

(2009) Xinkai Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization

(2009) Jason M. Crawford et al.   NATURE

A free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis

(2009) S. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complete Reconstitution of a Highly Reducing Iterative Polyketide Synthase

(2009) S. M. Ma et al.   SCIENCE

Three Thioesterases Are Involved in the Biosynthesis of Phosphinothricin Tripeptide in Streptomyces viridochromogenes Tu494

(2008) S. Eys et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tetramic and tetronic acids: An update on new derivatives and biological aspects

(2008) Rainer Schobert et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Medium- and short-chain dehydrogenase/reductase gene and protein families

(2008) K. L. Kavanagh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Authentic Heterologous Expression of the Tenellin Iterative Polyketide Synthase Nonribosomal Peptide Synthetase Requires Coexpression with an Enoyl Reductase

(2008) Laura M. Halo et al.   CHEMBIOCHEM

How Nature Morphs Peptide Scaffolds into Antibiotics

(2008) Elizabeth M. Nolan et al.   CHEMBIOCHEM

Mechanism of Thioesterase-Catalyzed Chain Release in the Biosynthesis of the Polyether Antibiotic Nanchangmycin

(2008) Tiangang Liu et al.   CHEMISTRY & BIOLOGY

Biosynthesis of Enediyne Antitumor Antibiotics

(2008) Steven Van Lanen et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Structure and Functional Analysis of RifR, the Type II Thioesterase from the Rifamycin Biosynthetic Pathway

(2008) Heather B. Claxton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biosynthesis of sphinganine-analog mycotoxins

(2008) L. Du et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Biosynthesis of 3-Hydroxy-5-Methyl-O-Methyltyrosine in the Saframycin/Safracin Biosynthetic Pathway

(2008) Cheng-Yu Fu   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Characterization of a Carbonyl-Conjugated Polyene Precursor in 10-Membered Enediyne Biosynthesis

(2008) Rong Kong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of the Two-Component, FAD-Dependent Monooxygenase SgcC That Requires Carrier Protein-Tethered Substrates for the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027

(2008) Shuangjun Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thioesterase-Like Role for Fungal PKS-NRPS Hybrid Reductive Domains

(2008) James W. Sims et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Myxochelin Biosynthesis: Direct Evidence for Two- and Four-Electron Reduction of a Carrier Protein-Bound Thioester

(2008) Yanyan Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Late Stage Oxidations during the Biosynthesis of the 2-Pyridone Tenellin in the Entomopathogenic FungusBeauveria bassiana

(2008) Laura M. Halo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways

(2008) Elizabeth S. Sattely et al.   NATURAL PRODUCT REPORTS

Dynamic thiolation–thioesterase structure of a non-ribosomal peptide synthetase

(2008) Dominique P. Frueh et al.   NATURE

Structural basis for the selectivity of the external thioesterase of the surfactin synthetase

(2008) Alexander Koglin et al.   NATURE

An Antibiotic Complex fromLysobacter enzymogenesStrain C3: Antimicrobial Activity and Role in Plant Disease Control

(2008) S. Li et al.   PHYTOPATHOLOGY

A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis

(2008) J. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure and functional analysis of tetracenomycin ARO/CYC: Implications for cyclization specificity of aromatic polyketides

(2008) B. D. Ames et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae

(2008) H. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deconstruction of Iterative Multidomain Polyketide Synthase Function

(2008) J. M. Crawford et al.   SCIENCE