Structural and evolutionary relationships of “AT-less” type I polyketide synthase ketosynthases

A Double-Hotdog with a New Trick: Structure and Mechanism of the trans-Acyltransferase Polyketide Synthase Enoyl-isomerase

(2014) Darren C. Gay et al.   ACS Chemical Biology

Acyl-Chain Elongation Drives Ketosynthase Substrate Selectivity intrans-Acyltransferase Polyketide Synthases

(2014) Matthew Jenner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Comparative Characterization of the Lactimidomycin and iso-Migrastatin Biosynthetic Machineries Revealing Unusual Features for Acyltransferase-less Type I Polyketide Synthases and Providing an Opportunity To Engineer New Analogues

(2014) Jeong-Woo Seo et al.   BIOCHEMISTRY

Cis-Double Bond Formation by Thioesterase and Transfer by Ketosynthase in FR901464 Biosynthesis

(2014) Hai-Yan He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Close Look at a Ketosynthase from a Trans-Acyltransferase Modular Polyketide Synthase

(2014) Darren C. Gay et al.   STRUCTURE

An Enzymatic Domain for the Formation of Cyclic Ethers in Complex Polyketides

(2013) Petra Pöplau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Vinylogous chain branching catalysed by a dedicated polyketide synthase module

(2013) Tom Bretschneider et al.   NATURE

Amino acid-accepting ketosynthase domain from a trans-AT polyketide synthase exhibits high selectivity for predicted intermediate

(2013) Christoph Kohlhaas et al.   Chemical Science

Substrate Specificity in Ketosynthase Domains fromtrans-AT Polyketide Synthases

(2012) Matthew Jenner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Natural Product Domain Seeker NaPDoS: A Phylogeny Based Bioinformatic Tool to Classify Secondary Metabolite Gene Diversity

(2012) Nadine Ziemert et al.   PLoS One

Discrete acyltransferases involved in polyketide biosynthesis

(2012) Ewa Maria Musiol et al.   MedChemComm

Oxazolomycin Biosynthesis inStreptomyces albusJA3453 Featuring an “Acyltransferase-less” Type I Polyketide Synthase That Incorporates Two Distinct Extender Units

(2010) Chunhua Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biosynthesis of polyketides by trans-AT polyketide synthases

(2010) Jörn Piel   NATURAL PRODUCT REPORTS

Polyketide-Chain Branching by an Enzymatic Michael Addition

(2009) Björn Kusebauch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

iso-Migrastatin, Migrastatin, and Dorrigocin Production in Streptomyces platensis NRRL 18993 Is Governed by a Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase

(2009) Si-Kyu Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Using Sequence Similarity Networks for Visualization of Relationships Across Diverse Protein Superfamilies

(2009) Holly J. Atkinson et al.   PLoS One

Long-Branch Attraction Bias and Inconsistency in Bayesian Phylogenetics

(2009) Bryan Kolaczkowski et al.   PLoS One

Isoprenoid-like alkylations in polyketide biosynthesis

(2008) Christopher T. Calderone   NATURAL PRODUCT REPORTS

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

(2008) TuAnh Nguyen et al.   NATURE BIOTECHNOLOGY