Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice

The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Is a Potent Inhibitor of ATM- and DNA-PKCs-Mediated DNA Damage Responses

(2015) Bipasha Mukherjee et al.   NEOPLASIA

Identification of Missing Proteins in the neXtProt Database and Unregistered Phosphopeptides in the PhosphoSitePlus Database As Part of the Chromosome-Centric Human Proteome Project

(2013) Takashi Shiromizu et al.   JOURNAL OF PROTEOME RESEARCH

RIF1 in DNA Break Repair Pathway Choice

(2013) James M. Daley et al.   MOLECULAR CELL

The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break Repair

(2013) Hailong Wang et al.   PLoS Genetics

Controlling DNA-end resection: a new task for CDKs

(2013) Lorenza P. Ferretti et al.   Frontiers in Genetics

14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif

(2012) Sofie Dabros Andersen et al.   DNA REPAIR

Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions

(2012) Nozomi Tomimatsu et al.   DNA REPAIR

CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination

(2012) Jacob Falck et al.   EMBO REPORTS

Activation of DSB Processing Requires Phosphorylation of CtIP by ATR

(2012) Shaun E. Peterson et al.   MOLECULAR CELL

The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection

(2012) Thomas Costelloe et al.   NATURE

Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2

(2012) Jeffrey Buis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family

(2011) Jillian Orans et al.   CELL

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

(2011) A. V. Nimonkar et al.   GENES & DEVELOPMENT

Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks

(2011) Lilach Moyal et al.   MOLECULAR CELL

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

(2011) Xuefeng Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PTEN Loss Compromises Homologous Recombination Repair in Astrocytes: Implications for Glioblastoma Therapy with Temozolomide or Poly(ADP-Ribose) Polymerase Inhibitors

(2010) B. McEllin et al.   CANCER RESEARCH

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks

(2010) Sascha E. Liberti et al.   DNA REPAIR

DNA end resection by CtIP and exonuclease 1 prevents genomic instability

(2010) Wassim Eid et al.   EMBO REPORTS

Mre11–Rad50–Xrs2 and Sae2 promote 5′ strand resection of DNA double-strand breaks

(2010) Matthew L Nicolette et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA resection in eukaryotes: deciding how to fix the break

(2010) Pablo Huertas   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CDC25B Mediates Rapamycin-Induced Oncogenic Responses in Cancer Cells

(2009) R.-q. Chen et al.   CANCER RESEARCH

Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells

(2009) Nozomi Tomimatsu et al.   EMBO REPORTS

Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair

(2009) Pablo Huertas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts

(2009) K. F. Byth et al.   MOLECULAR CANCER THERAPEUTICS

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

(2009) Maximina H. Yun et al.   NATURE

BRCA1 and its toolbox for the maintenance of genome integrity

(2009) Michael S.Y. Huen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks

(2009) Emma Bolderson et al.   NUCLEIC ACIDS RESEARCH

Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends

(2008) Zhu Zhu et al.   CELL

DNA helicases Sgs1 and BLM promote DNA double-strand break resection

(2008) S. Gravel et al.   GENES & DEVELOPMENT

Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair

(2008) Longchuan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

(2008) Eleni P. Mimitou et al.   NATURE

CDK targets Sae2 to control DNA-end resection and homologous recombination

(2008) Pablo Huertas et al.   NATURE