P53 functional abnormality in mesenchymal stem cells promotes osteosarcoma development

Stem cells and bone: A historical perspective

(2015) Paolo Bianco   BONE

TAp73 transcriptionally represses BNIP3 expression

(2015) Varvara Petrova et al.   CELL CYCLE

TP53: an oncogene in disguise

(2015) T Soussi et al.   CELL DEATH AND DIFFERENTIATION

Bone microenvironment signals in osteosarcoma development

(2015) Arantzazu Alfranca et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

p63 sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling

(2015) Elisa Maria Memmi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p63 supports aerobic respiration through hexokinase II

(2015) Guiditta Viticchiè et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maintaining epithelial stemness with p63

(2015) Gerry Melino et al.   Science Signaling

p53 Loss Increases the Osteogenic Differentiation of Bone Marrow Stromal Cells

(2015) Yunlong He et al.   STEM CELLS

The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progression

(2015) Ivano Amelio et al.   TRENDS IN BIOCHEMICAL SCIENCES

Genome-editing tools for stem cell biology

(2015) E A Vasileva et al.   Cell Death & Disease

Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant

(2015) T L Slatter et al.   Cell Death & Disease

Anti-tumoral effect of desmethylclomipramine in lung cancer stem cells

(2015) Lucilla Bongiorno-Borbone et al.   Oncotarget

Polypharmacology of small molecules targeting the ubiquitin–proteasome and ubiquitin-like systems

(2015) Ivano Amelio et al.   Oncotarget

KMT Set7/9 affects genotoxic stress response via the Mdm2 axis

(2015) Larissa Lezina et al.   Oncotarget

The 26S proteasome is a multifaceted target for anti-cancer therapies

(2015) Tatyana A. Grigoreva et al.   Oncotarget

Maintaining epithelial stemness with p63

(2015) Gerry Melino et al.   Science Signaling

Loss of p53 Induces Tumorigenesis in p21-Deficient Mesenchymal Stem Cells

(2015) Rene Rodriguez et al.   NEOPLASIA

Bone resorption facilitates osteoblastic bone metastatic colonization by cooperation of insulin-like growth factor and hypoxia

(2014) Takahiro Kuchimaru et al.   CANCER SCIENCE

Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response

(2014) B C Nair et al.   CELL DEATH AND DIFFERENTIATION

KMTase Set7/9 is a critical regulator of E2F1 activity upon genotoxic stress

(2014) L Lezina et al.   CELL DEATH AND DIFFERENTIATION

Suppression of acetylpolyamine oxidase by selected AP-1 members regulates DNp73 abundance: mechanistic insights for overcoming DNp73-mediated resistance to chemotherapeutic drugs

(2014) W Bunjobpol et al.   CELL DEATH AND DIFFERENTIATION

CRISPR: a new method for genetic engineering – A prokaryotic immune component may potentially open a new era of gene silencing

(2014) I Amelio et al.   CELL DEATH AND DIFFERENTIATION

Oxidative stress-induced p53 activity is enhanced by a redox-sensitive TP53INP1 SUMOylation

(2014) S Peuget et al.   CELL DEATH AND DIFFERENTIATION

MicroRNAs and p63 in epithelial stemness

(2014) E Candi et al.   CELL DEATH AND DIFFERENTIATION

Expanding the reach of the p53 tumor suppressor network

(2014) G P Zambetti   CELL DEATH AND DIFFERENTIATION

Modulation of alternative splicing contributes to cancer development: focusing on p53 isoforms, p53β and p53γ

(2014) H Solomon et al.   CELL DEATH AND DIFFERENTIATION

Modulation of p53β and p53γ expression by regulating the alternative splicing of TP53 gene modifies cellular response

(2014) V Marcel et al.   CELL DEATH AND DIFFERENTIATION

p63 and p73 coordinate p53 function to determine the balance between survival, cell death and senescence in adult neural precursor cells

(2014) M P Fatt et al.   CELL DEATH AND DIFFERENTIATION

Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo

(2014) T J Phesse et al.   CELL DEATH AND DIFFERENTIATION

p63 is a prosurvival factor in the adult mammary gland during post-lactational involution, affecting PI-MECs and ErbB2 tumorigenesis

(2014) A R Yallowitz et al.   CELL DEATH AND DIFFERENTIATION

AMPK couples p73 with p53 in cell fate decision

(2014) Y Adamovich et al.   CELL DEATH AND DIFFERENTIATION

E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis

(2014) Ju Liu et al.   CELL DEATH AND DIFFERENTIATION

Nemo-like kinase is critical for p53 stabilization and function in response to DNA damage

(2014) H-H Zhang et al.   CELL DEATH AND DIFFERENTIATION

Antitumor effect of miR-197 targeting in p53 wild-type lung cancer

(2014) M E Fiori et al.   CELL DEATH AND DIFFERENTIATION

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

(2014) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

A unique role for p53 in the regulation of M2 macrophage polarization

(2014) L Li et al.   CELL DEATH AND DIFFERENTIATION

p53: The barrier to cancer stem cell formation

(2014) Ronit Aloni-Grinstein et al.   FEBS LETTERS

TAp73 is required for spermatogenesis and the maintenance of male fertility

(2014) Satoshi Inoue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation

(2014) Ivano Amelio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells

(2014) S Sane et al.   Cell Death & Disease

ROS inhibit autophagy by downregulating ULK1 mediated by the phosphorylation of p53 in selenite-treated NB4 cells

(2014) Y Ci et al.   Cell Death & Disease

A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways

(2014) J Cheng et al.   Cell Death & Disease

ΔNp63α activates CD82 metastasis suppressor to inhibit cancer cell invasion

(2014) J Wu et al.   Cell Death & Disease

JNK–NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stress

(2014) A Kostecka et al.   Cell Death & Disease

Mir-660 is downregulated in lung cancer patients and its replacement inhibits lung tumorigenesis by targeting MDM2-p53 interaction

(2014) O Fortunato et al.   Cell Death & Disease

ATG5 can regulate p53 expression and activation

(2014) H U Simon et al.   Cell Death & Disease

The traditional Chinese medical compound Rocaglamide protects nonmalignant primary cells from DNA damage-induced toxicity by inhibition of p53 expression

(2014) M S Becker et al.   Cell Death & Disease

RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38

(2014) A Weilbacher et al.   Cell Death & Disease

p53 induces skin aging by depleting Blimp1+ sebaceous gland cells

(2014) J Kim et al.   Cell Death & Disease

Mir-509-5p joins the Mdm2/p53 feedback loop and regulates cancer cell growth

(2014) Z-J Ren et al.   Cell Death & Disease

Degradation of mutant p53H175 protein by Zn(II) through autophagy

(2014) A Garufi et al.   Cell Death & Disease

Unequal prognostic potentials of p53 gain-of-function mutations in human cancers associate with drug-metabolizing activity

(2014) J Xu et al.   Cell Death & Disease

High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy

(2014) M Rossi et al.   Cell Death & Disease

A sustained deficiency of mitochondrial respiratory complex III induces an apoptotic cell death through the p53-mediated inhibition of pro-survival activities of the activating transcription factor 4

(2014) A G Evstafieva et al.   Cell Death & Disease

Palmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage

(2014) N Dashzeveg et al.   Cell Death & Disease

Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA

(2013) Anthony J. Mutsaers et al.   BONE

Trp53 Inactivation in the Tumor Microenvironment Promotes Tumor Progression by Expanding the Immunosuppressive Lymphoid-like Stromal Network

(2013) G. Guo et al.   CANCER RESEARCH

miR-661 downregulates both Mdm2 and Mdm4 to activate p53

(2013) Y Hoffman et al.   CELL DEATH AND DIFFERENTIATION

p73 regulates serine biosynthesis in cancer

(2013) I Amelio et al.   ONCOGENE

p53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation

(2013) Y Huang et al.   ONCOGENE

Senescence and aging: the critical roles of p53

(2013) A Rufini et al.   ONCOGENE

TAp73 knockout mice show morphological and functional nervous system defects associated with loss of p75 neurotrophin receptor

(2013) M. V. Niklison-Chirou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor suppressor WWOX binds to ΔNp63α and sensitizes cancer cells to chemotherapy

(2013) Z Salah et al.   Cell Death & Disease

Role of the p63-FoxN1 regulatory axis in thymic epithelial cell homeostasis during aging

(2013) P Burnley et al.   Cell Death & Disease

Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome

(2013) C Manzl et al.   Cell Death & Disease

Perspectives on cancer stem cells in osteosarcoma

(2012) Upal Basu-Roy et al.   CANCER LETTERS

Hierarchical organization and regulation of the hematopoietic stem cell osteoblastic niche

(2012) Hongxu Wang et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Expression and stability of hypoxia inducible factor 1α in osteosarcoma

(2012) Amal El Naggar et al.   PEDIATRIC BLOOD & CANCER

CCL5 and CCR5 Interaction Promotes Cell Motility in Human Osteosarcoma

(2012) Shih-Wei Wang et al.   PLoS One

Biological functions of p53 isoforms through evolution: lessons from animal and cellular models

(2011) V Marcel et al.   CELL DEATH AND DIFFERENTIATION

p53 Status in Stromal Fibroblasts Modulates Tumor Growth in an SDF1-Dependent Manner

(2010) Y. Addadi et al.   CANCER RESEARCH

p53 is balancing development, differentiation and de-differentiation to assure cancer prevention

(2010) A. Molchadsky et al.   CARCINOGENESIS

Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair

(2010) Yufang Shi et al.   CELL RESEARCH

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Expression of Mutant p53 Proteins Implicates a Lineage Relationship between Neural Stem Cells and Malignant Astrocytic Glioma in a Murine Model

(2009) Yuan Wang et al.   CANCER CELL

Human mesenchymal stem cells (hMSCs) target osteosarcoma and promote its growth and pulmonary metastasis

(2009) Wen-ting Xu et al.   CANCER LETTERS

Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice

(2009) P. P. Lin et al.   CARCINOGENESIS

p53 Regulates Hematopoietic Stem Cell Quiescence

(2009) Yan Liu et al.   Cell Stem Cell

Bone tumors: osteosarcoma and Ewingʼs sarcoma

(2009) Travis Heare et al.   CURRENT OPINION IN PEDIATRICS

The non-apoptotic role of p53 in neuronal biology: enlightening the dark side of the moon

(2009) Andrea Tedeschi et al.   EMBO REPORTS

p53 regulates the proliferation, differentiation and spontaneous transformation of mesenchymal stem cells

(2009) Alejandro Armesilla-Diaz et al.   EXPERIMENTAL CELL RESEARCH

Clinical Outcomes and Correlates of TP53 Mutations and Cancer

(2009) A. I. Robles et al.   Cold Spring Harbor Perspectives in Biology

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology

Attenuated p53 activation in tumour-associated stromal cells accompanies decreased sensitivity to etoposide and vincristine

(2008) A C Dudley et al.   BRITISH JOURNAL OF CANCER

A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs

(2008) Mihaela Crisan et al.   Cell Stem Cell

Normal Bone Anatomy and Physiology

(2008) B. Clarke   Clinical Journal of the American Society of Nephrology

Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease

(2008) C. R. Walkley et al.   GENES & DEVELOPMENT

p53 Plays a Role in Mesenchymal Differentiation Programs, in a Cell Fate Dependent Manner

(2008) Alina Molchadsky et al.   PLoS One