- Home
- Publications
- Publication Search
- Publication Details
Title
Bone microenvironment signals in osteosarcoma development
Authors
Keywords
Bone sarcoma, Growth plate, Osteoblast, Osteoclast, Tumor stroma, Microenvironment signaling, Mesenchymal stem cell, MicroRNA
Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 72, Issue 16, Pages 3097-3113
Publisher
Springer Nature
Online
2015-05-02
DOI
10.1007/s00018-015-1918-y
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- RANK Ligand Blockade with Denosumab in Combination with Sorafenib in Chemorefractory Osteosarcoma: A Possible Step Forward?
- (2015) Richard Cathomas et al. ONCOLOGY
- Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells
- (2015) Gloria Bonuccelli et al. Oncotarget
- Transforming growth factor alpha promotes osteosarcoma metastasis by ICAM-1 and PI3K/Akt signaling pathway
- (2014) Chun-Han Hou et al. BIOCHEMICAL PHARMACOLOGY
- The genetic basis for inactivation of Wnt pathway in human osteosarcoma
- (2014) Xiaoling Du et al. BMC CANCER
- Cells of origin in osteosarcoma: Mesenchymal stem cells or osteoblast committed cells?
- (2014) Anthony J. Mutsaers et al. BONE
- Notch Activation as a Driver of Osteogenic Sarcoma
- (2014) Jianning Tao et al. CANCER CELL
- Wnt5a promotes migration of human osteosarcoma cells by triggering a phosphatidylinositol-3 kinase/Akt signals
- (2014) Ailiang Zhang et al. Cancer Cell International
- Platelets promote osteosarcoma cell growth through activation of the platelet-derived growth factor receptor-Akt signaling axis
- (2014) Satoshi Takagi et al. CANCER SCIENCE
- Bone resorption facilitates osteoblastic bone metastatic colonization by cooperation of insulin-like growth factor and hypoxia
- (2014) Takahiro Kuchimaru et al. CANCER SCIENCE
- CCL5/CCR5 axis induces vascular endothelial growth factor-mediated tumor angiogenesis in human osteosarcoma microenvironment
- (2014) Shih-Wei Wang et al. CARCINOGENESIS
- Overexpression of Smad7 Blocks Primary Tumor Growth and Lung Metastasis Development in Osteosarcoma
- (2014) A. Lamora et al. CLINICAL CANCER RESEARCH
- Transforming Growth Factor-Beta Polymorphisms and Serum Level in the Development of Osteosarcoma
- (2014) Shaogang Xu et al. DNA AND CELL BIOLOGY
- Vasculogenic mimicry: a new prognostic sign of human osteosarcoma
- (2014) Ke Ren et al. HUMAN PATHOLOGY
- Roles of bone morphogenetic protein signaling in osteosarcoma
- (2014) Alan Nguyen et al. INTERNATIONAL ORTHOPAEDICS
- Age-specific bone tumour incidence rates are governed by stem cell exhaustion influencing the supply and demand of progenitor cells
- (2014) Richard B. Richardson MECHANISMS OF AGEING AND DEVELOPMENT
- Autocrine VEGF/VEGFR1 Signaling in a Subpopulation of Cells Associates with Aggressive Osteosarcoma
- (2014) Tetsuro Ohba et al. MOLECULAR CANCER RESEARCH
- Hypoxia Promotes Migration and Induces CXCR4 Expression via HIF-1α Activation in Human Osteosarcoma
- (2014) Mingjun Guo et al. PLoS One
- Insulin-Like Growth Factor 1 Receptor and Response to Anti-IGF1R Antibody Therapy in Osteosarcoma
- (2014) Yu Cao et al. PLoS One
- Down Regulation of Wnt Signaling Mitigates Hypoxia-Induced Chemoresistance in Human Osteosarcoma Cells
- (2014) Donald J. Scholten et al. PLoS One
- Bone Environment is Essential for Osteosarcoma Development from Transformed Mesenchymal Stem Cells
- (2014) Ruth Rubio et al. STEM CELLS
- Extracellular Membrane Vesicles Derived from 143B Osteosarcoma Cells Contain Pro-Osteoclastogenic Cargo: A Novel Communication Mechanism in Osteosarcoma Bone Microenvironment
- (2014) Rama Garimella et al. Translational Oncology
- Tumor-stromal cross talk: direct cell-to-cell transfer of oncogenic microRNAs via tunneling nanotubes
- (2014) Venugopal Thayanithy et al. Translational Research
- Wnt/β-catenin pathway in bone cancers
- (2014) Jian Tian et al. TUMOR BIOLOGY
- An unexpected role for a Wnt-inhibitor: Dickkopf-1 triggers a novel cancer survival mechanism through modulation of aldehyde-dehydrogenase-1 activity
- (2014) U Krause et al. Cell Death & Disease
- Human Bone Marrow Stromal Cells Lose Immunosuppressive and Anti-inflammatory Properties upon Oncogenic Transformation
- (2014) Rene Rodriguez et al. Stem Cell Reports
- MicroRNA function and dysregulation in bone tumors: the evidence to date
- (2014) Mary Nugent Cancer Management and Research
- Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy
- (2013) Yimin Ma et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- MicroRNA-340 suppresses osteosarcoma tumor growth and metastasis by directly targeting ROCK1
- (2013) Xin Zhou et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- IL-17A/IL-17RA interaction promoted metastasis of osteosarcoma cells
- (2013) Mingmin Wang et al. CANCER BIOLOGY & THERAPY
- CCN3 promotes prostate cancer bone metastasis by modulating the tumor–bone microenvironment through RANKL-dependent pathway
- (2013) Po-Chun Chen et al. CARCINOGENESIS
- Reoxygenation using a novel CO2 therapy decreases the metastatic potential of osteosarcoma cells
- (2013) Risa Harada et al. EXPERIMENTAL CELL RESEARCH
- Osteosarcoma cells promote the production of pro-tumor cytokines in mesenchymal stem cells by inhibiting their osteogenic differentiation through the TGF-β/Smad2/3 pathway
- (2013) Bing Tu et al. EXPERIMENTAL CELL RESEARCH
- Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation
- (2013) Maya Kansara et al. JOURNAL OF CLINICAL INVESTIGATION
- Hedgehog signaling induces osteosarcoma development through Yap1 and H19 overexpression
- (2013) L H Chan et al. ONCOGENE
- MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma
- (2013) Aaron L Sarver et al. Orphanet Journal of Rare Diseases
- Hypoxia–Induced Cytotoxic Drug Resistance in Osteosarcoma Is Independent of HIF-1Alpha
- (2013) Jennifer Adamski et al. PLoS One
- B7-H3 is Overexpressed in Patients Suffering Osteosarcoma and Associated with Tumor Aggressiveness and Metastasis
- (2013) Ling Wang et al. PLoS One
- A systematic review of vascular endothelial growth factor expression as a biomarker of prognosis in patients with osteosarcoma
- (2013) Ding Chen et al. TUMOR BIOLOGY
- How MicroRNA and Transcription Factor Co-regulatory Networks Affect Osteosarcoma Cell Proliferation
- (2013) Kathrin Poos et al. PLoS Computational Biology
- A Review of Targeted Therapies Evaluated by the Pediatric Preclinical Testing Program for Osteosarcoma
- (2013) Valerie B. Sampson et al. Frontiers in Oncology
- Additive Influence of Extracellular pH, Oxygen Tension, and Pressure on Invasiveness and Survival of Human Osteosarcoma Cells
- (2013) Takao Matsubara et al. Frontiers in Oncology
- STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma
- (2012) Bing Tu et al. CANCER LETTERS
- Perspectives on cancer stem cells in osteosarcoma
- (2012) Upal Basu-Roy et al. CANCER LETTERS
- Mesenchymal stem cells as all-round supporters in a normal and neoplastic microenvironment
- (2012) Ralf Hass et al. Cell Communication and Signaling
- Anti-TGF-β Antibody Combined with Dendritic Cells Produce Antitumor Effects in Osteosarcoma
- (2012) Masanori Kawano et al. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
- The activities of Smad and Gli mediated signalling pathways in high-grade conventional osteosarcoma
- (2012) Alexander B. Mohseny et al. EUROPEAN JOURNAL OF CANCER
- Osteosarcoma cells induce endothelial cell proliferation during neo-angiogenesis
- (2012) Filomena de Nigris et al. JOURNAL OF CELLULAR PHYSIOLOGY
- An osteosarcoma zebrafish model implicates Mmp-19 and Ets-1 as well as reduced host immune response in angiogenesis and migration
- (2012) Alexander B Mohseny et al. JOURNAL OF PATHOLOGY
- Fibroblast Growth Factor-2 Is an Important Factor that Maintains Cellular Immaturity and Contributes to Aggressiveness of Osteosarcoma
- (2012) T. Shimizu et al. MOLECULAR CANCER RESEARCH
- The differentiation stage of p53-Rb-deficient bone marrow mesenchymal stem cells imposes the phenotype of in vivo sarcoma development
- (2012) R Rubio et al. ONCOGENE
- Expression and stability of hypoxia inducible factor 1α in osteosarcoma
- (2012) Amal El Naggar et al. PEDIATRIC BLOOD & CANCER
- CCL5 and CCR5 Interaction Promotes Cell Motility in Human Osteosarcoma
- (2012) Shih-Wei Wang et al. PLoS One
- Transforming Growth Factor β1 Signal is Crucial for Dedifferentiation of Cancer Cells to Cancer Stem Cells in Osteosarcoma
- (2012) Haixia Zhang et al. STEM CELLS
- MS-275 sensitizes osteosarcoma cells to Fas ligand-induced cell death by increasing the localization of Fas in membrane lipid rafts
- (2012) K Rao-Bindal et al. Cell Death & Disease
- Bone cell interactions through Eph/ephrin
- (2012) Koichi Matsuo et al. Cell Adhesion & Migration
- Cell surface receptor expression patterns in osteosarcoma
- (2011) Sheref E. Hassan et al. CANCER
- BMP-2 inhibits the tumorigenicity of cancer stem cells in human osteosarcoma OS99-1 cell line
- (2011) Lin Wang et al. CANCER BIOLOGY & THERAPY
- Immunotherapy targeting HER2 with genetically modified T cells eliminates tumor-initiating cells in osteosarcoma
- (2011) N Rainusso et al. CANCER GENE THERAPY
- Hypoxia, stem cells and bone tumor
- (2011) Wen Zeng et al. CANCER LETTERS
- HMGB1 Promotes Drug Resistance in Osteosarcoma
- (2011) J. Huang et al. CANCER RESEARCH
- Modeling sarcomagenesis using multipotent mesenchymal stem cells
- (2011) Rene Rodriguez et al. CELL RESEARCH
- Paracrine-mediated osteoclastogenesis by the osteosarcoma MG63 cell line: is RANKL/RANK signalling really important?
- (2011) J. Costa-Rodrigues et al. CLINICAL & EXPERIMENTAL METASTASIS
- Parathyroid hormone affects the fibroblast growth factor-proteoglycan signaling axis to regulate osteosarcoma cell migration
- (2011) Georgios A. Datsis et al. FEBS Journal
- Cyr61 expression in osteosarcoma indicates poor prognosis and promotes intratibial growth and lung metastasis in mice
- (2011) Adam A Sabile et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Formulated siRNAs targeting Rankl prevent osteolysis and enhance chemotherapeutic response in osteosarcoma models
- (2011) Julie Rousseau et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Reciprocal osteoblastic and osteoclastic modulation in co-cultured MG63 osteosarcoma cells and human osteoclast precursors
- (2011) João Costa-Rodrigues et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas
- (2011) U Basu-Roy et al. ONCOGENE
- Tumor-Conditioned Mesenchymal Stem Cells Display Hematopoietic Differentiation and Diminished Influx of Ca2+
- (2011) Liyang Zhang et al. STEM CELLS AND DEVELOPMENT
- Extracellular heat shock protein HSP90β secreted by MG63 osteosarcoma cells inhibits activation of latent TGF-β1
- (2010) Shigeki Suzuki et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Arsenic trioxide inhibits osteosarcoma cell invasiveness via MAPK signaling pathway
- (2010) Ren Tingting et al. CANCER BIOLOGY & THERAPY
- CD117 and Stro-1 Identify Osteosarcoma Tumor-Initiating Cells Associated with Metastasis and Drug Resistance
- (2010) Amit S. Adhikari et al. CANCER RESEARCH
- Deficiency in p53 but not Retinoblastoma Induces the Transformation of Mesenchymal Stem Cells In vitro and Initiates Leiomyosarcoma In vivo
- (2010) R. Rubio et al. CANCER RESEARCH
- Loss of Osteoclasts Contributes to Development of Osteosarcoma Pulmonary Metastases
- (2010) L. Endo-Munoz et al. CANCER RESEARCH
- Human mesenchymal stem cells promote growth of osteosarcoma: Involvement of interleukin-6 in the interaction between human mesenchymal stem cells and Saos-2
- (2010) Zhen-Yu Bian et al. CANCER SCIENCE
- Therapeutic Approach of Primary Bone Tumours by Bisphosphonates
- (2010) G. Moriceau et al. CURRENT PHARMACEUTICAL DESIGN
- De novo expression of EphA2 in osteosarcoma modulates activation of the mitogenic signalling pathway
- (2010) Raphaela Fritsche-Guenther et al. HISTOPATHOLOGY
- Ephrin A4 expression in osteosarcoma, impact on prognosis, and patient outcome
- (2010) AG Abdou et al. INDIAN JOURNAL OF CANCER
- Prospective identification of tumorigenic osteosarcoma cancer stem cells in OS99-1 cells based on high aldehyde dehydrogenase activity
- (2010) Lin Wang et al. INTERNATIONAL JOURNAL OF CANCER
- Mesenchymal stromal cells from primary osteosarcoma are non-malignant and strikingly similar to their bone marrow counterparts
- (2010) Jan C. Brune et al. INTERNATIONAL JOURNAL OF CANCER
- Micro-RNA profiles in osteosarcoma as a predictive tool for ifosfamide response
- (2010) Angélique Gougelet et al. INTERNATIONAL JOURNAL OF CANCER
- RANKL expression is related to treatment outcome of patients with localized, high-grade osteosarcoma
- (2010) Jun Ah Lee et al. PEDIATRIC BLOOD & CANCER
- Prognostic significance of early lymphocyte recovery in pediatric osteosarcoma
- (2010) Colin Moore et al. PEDIATRIC BLOOD & CANCER
- Targeting the osteosarcoma cancer stem cell
- (2010) Valerie A Siclari et al. Journal of Orthopaedic Surgery and Research
- Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation
- (2009) M Tanaka et al. BRITISH JOURNAL OF CANCER
- Human mesenchymal stem cells (hMSCs) target osteosarcoma and promote its growth and pulmonary metastasis
- (2009) Wen-ting Xu et al. CANCER LETTERS
- Morphology and physiology of the epiphyseal growth plate.
- (2009) Franciszek Burdan et al. FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
- Notch signaling contributes to the pathogenesis of human osteosarcomas
- (2009) F. Engin et al. HUMAN MOLECULAR GENETICS
- Inactive Wnt/β-catenin pathway in conventional high-grade osteosarcoma
- (2009) Yongping Cai et al. JOURNAL OF PATHOLOGY
- Functions of RANKL/RANK/OPG in bone modeling and remodeling
- (2008) Brendan F. Boyce et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- A complex pattern of chemokine receptor expression is seen in osteosarcoma
- (2008) Irene von Luettichau et al. BMC CANCER
- Carcinoma-Associated Fibroblast-Like Differentiation of Human Mesenchymal Stem Cells
- (2008) P. J. Mishra et al. CANCER RESEARCH
- Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects
- (2008) Xiaoji Luo et al. LABORATORY INVESTIGATION
- Therapeutic efficacy of soluble receptor activator of nuclear factor-κB-Fc delivered by nonviral gene transfer in a mouse model of osteolytic osteosarcoma
- (2008) François Lamoureux et al. MOLECULAR CANCER THERAPEUTICS
- The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC
- (2008) L Ren et al. ONCOGENE
- Therapy for Osteosarcoma
- (2008) Alexander J Chou et al. PEDIATRIC DRUGS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More