High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

(2013) S. Inoue et al.   GENES & DEVELOPMENT

The E3 ubiquitin ligase Itch regulates tumor suppressor protein RASSF5/NORE1 stability in an acetylation-dependent manner

(2013) R Suryaraja et al.   Cell Death & Disease

Recognition mechanism of p63 by the E3 ligase Itch

(2012) Alessia Bellomaria et al.   CELL CYCLE

The Cul4A–DDB1 E3 ubiquitin ligase complex represses p73 transcriptional activity

(2012) M Malatesta et al.   ONCOGENE

Negative Regulation of the Hippo Pathway by E3 Ubiquitin Ligase ITCH Is Sufficient to Promote Tumorigenicity

(2011) Z. Salah et al.   CANCER RESEARCH

HECT-type Ubiquitin Ligase ITCH Targets Lysosomal-associated Protein Multispanning Transmembrane 5 (LAPTM5) and Prevents LAPTM5-mediated Cell Death

(2011) Takaya Ishihara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential altered stability and transcriptional activity of  Np63 mutants in distinct ectodermal dysplasias

(2011) G. Browne et al.   JOURNAL OF CELL SCIENCE

Ligand and Decoy Sets for Docking to G Protein-Coupled Receptors

(2011) Edgar A. Gatica et al.   Journal of Chemical Information and Modeling

Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability

(2011) K. C. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition of p63 by the E3 ligase ITCH: Effect of an ectodermal dysplasia mutant

(2010) Alessia Bellomaria et al.   CELL CYCLE

The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid

(2010) Bilal A. Azakir et al.   FEBS Journal

The Ubiquitin Ligase Itch Regulates Apoptosis by Targeting Thioredoxin-interacting Protein for Ubiquitin-dependent Degradation

(2010) Pingzhao Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand-Steered Modeling and Docking: A Benchmarking Study in Class A G-Protein-Coupled Receptors

(2010) Sharangdhar S. Phatak et al.   Journal of Chemical Information and Modeling

Differential control of TAp73 and  Np73 protein stability by the ring finger ubiquitin ligase PIR2

(2010) B. S. Sayan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The antiapoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway

(2010) I. Dulloo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome

(2010) D. Zaaroor-Regev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p73, miR106b, miR34a, and Itch in chronic lymphocytic leukemia

(2009) P. R. di Val Cervo et al.   BLOOD

2,3-Dihydro-1-Benzofuran Derivatives as a Series of Potent Selective Cannabinoid Receptor 2 Agonists: Design, Synthesis, and Binding Mode Prediction through Ligand-Steered Modeling

(2009) Philippe Diaz et al.   ChemMedChem

The Double-Edged Sword of Autophagy Modulation in Cancer

(2009) E. White et al.   CLINICAL CANCER RESEARCH

Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux

(2009) M. Rossi et al.   JOURNAL OF CELL SCIENCE

Insights into Ubiquitin Transfer Cascades from a Structure of a UbcH5B∼Ubiquitin-HECTNEDD4L Complex

(2009) Hari B. Kamadurai et al.   MOLECULAR CELL

The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73

(2009) A Peschiaroli et al.   ONCOGENE

The ubiquitin-specific protease USP47 is a novel β-TRCP interactor regulating cell survival

(2009) A Peschiaroli et al.   ONCOGENE

Caspase cleavage of Itch in chronic lymphocytic leukemia cells

(2008) Mario Rossi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modelling and molecular dynamics of the interaction between the E3 ubiquitin ligase Itch and the E2 UbcH7

(2008) Domenico Raimondo et al.   BIOCHEMICAL PHARMACOLOGY

Itch self-polyubiquitylation occurs through lysine-63 linkages

(2008) Flavia Scialpi et al.   BIOCHEMICAL PHARMACOLOGY

The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

(2008) Francesca Bernassola et al.   CANCER CELL

The Binding Mode of Petrosaspongiolide M to the Human Group IIA Phospholipase A2: Exploring the Role of Covalent and Noncovalent Interactions in the Inhibition Process

(2008) Maria Chiara Monti et al.   CHEMISTRY-A EUROPEAN JOURNAL

The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1

(2008) K Venuprasad et al.   NATURE IMMUNOLOGY

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

(2008) Noula Shembade et al.   NATURE IMMUNOLOGY

Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms

(2008) M. Sundvall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA