Maintaining epithelial stemness with p63

p63 sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling

(2015) Elisa Maria Memmi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p63 is a prosurvival factor in the adult mammary gland during post-lactational involution, affecting PI-MECs and ErbB2 tumorigenesis

(2014) A R Yallowitz et al.   CELL DEATH AND DIFFERENTIATION

 NP63  Transcriptionally Activates Chemokine Receptor 4 (CXCR4) Expression to Regulate Breast Cancer Stem Cell Activity and Chemotaxis

(2014) A. J. DeCastro et al.   MOLECULAR CANCER THERAPEUTICS

ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling

(2014) Rumela Chakrabarti et al.   NATURE CELL BIOLOGY

Wnt signaling in stem and cancer stem cells

(2013) Jane D Holland et al.   CURRENT OPINION IN CELL BIOLOGY

Notch signaling represses p63 expression in the developing surface ectoderm

(2013) A. M. B. Tadeu et al.   DEVELOPMENT

Cbx4 regulates the proliferation of thymic epithelial cells and thymus function

(2013) B. Liu et al.   DEVELOPMENT

Role of p63 and the Notch pathway in cochlea development and sensorineural deafness

(2013) A. Terrinoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia

(2013) J.-C. Pignon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 Np63 -Mediated Activation of Bone Morphogenetic Protein Signaling Governs Stem Cell Activity and Plasticity in Normal and Malignant Mammary Epithelial Cells

(2012) A. L. Balboni et al.   CANCER RESEARCH

 Np63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation

(2012) R.-A. Romano et al.   DEVELOPMENT

Increased p63 Phosphorylation Marks Early Transition of Epidermal Stem Cells to Progenitors

(2012) Daisuke Suzuki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer

(2012) P. Tucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch signaling mediates p63-induced quiescence

(2011) Nicole Forster et al.   CELL CYCLE

ΔNp63α promotes cellular quiescence via induction and activation of Notch3

(2011) Sierra Kent et al.   CELL CYCLE

p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53

(2011) G Melino   CELL DEATH AND DIFFERENTIATION

p63 regulatesSatb1to control tissue-specific chromatin remodeling during development of the epidermis

(2011) Michael Y. Fessing et al.   JOURNAL OF CELL BIOLOGY

p63, a Story of Mice and Men

(2011) Hans Vanbokhoven et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The p53 family: guardians of maternal reproduction

(2011) Arnold J. Levine et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

p63 Regulates Olfactory Stem Cell Self-Renewal and Differentiation

(2011) Russell B. Fletcher et al.   NEURON

p63in Epithelial Survival, Germ Cell Surveillance, and Neoplasia

(2010) Christopher P. Crum et al.   Annual Review of Pathology-Mechanisms of Disease

Overexpression of ΔNp63α induces a stem cell phenotype in MCF7 breast carcinoma cell line through the Notch pathway

(2010) Zhijian Du et al.   CANCER SCIENCE

Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content

(2010) Salvatore Pece et al.   CELL

Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates

(2010) Ö Yalcin-Ozuysal et al.   CELL DEATH AND DIFFERENTIATION

Genome-Wide Profiling of p63 DNA–Binding Sites Identifies an Element that Regulates Gene Expression during Limb Development in the 7q21 SHFM1 Locus

(2010) Evelyn N. Kouwenhoven et al.   PLoS Genetics

Lin-Sca-1+CD49fhigh Stem/Progenitors Are Tumor-Initiating Cells in the Pten-Null Prostate Cancer Model

(2009) D. J. Mulholland et al.   CANCER RESEARCH

The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells

(2009) Angelo Cicalese et al.   CELL

Mutant p53 Drives Invasion by Promoting Integrin Recycling

(2009) Patricia A.J. Muller et al.   CELL

A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

(2009) Maddalena Adorno et al.   CELL

TAp63 induces senescence and suppresses tumorigenesis in vivo

(2009) Xuecui Guo et al.   NATURE CELL BIOLOGY

Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment

(2008) Toula Bouras et al.   Cell Stem Cell

Reciprocal Intraepithelial Interactions Between TP63 and Hedgehog Signaling Regulate Quiescence and Activation of Progenitor Elaboration by Mammary Stem Cells

(2008) Na Li et al.   STEM CELLS

Characterization of Adult Prostatic Progenitor/Stem Cells Exhibiting Self-Renewal and Multilineage Differentiation

(2007) Wendy W. Barclay et al.   STEM CELLS