The traditional Chinese medical compound Rocaglamide protects nonmalignant primary cells from DNA damage-induced toxicity by inhibition of p53 expression

Evidence for a Functionally Relevant Rocaglamide Binding Site on the eIF4A–RNA Complex

(2013) Heather Sadlish et al.   ACS Chemical Biology

The p53 mRNA-Mdm2 Interaction Controls Mdm2 Nuclear Trafficking and Is Required for p53 Activation following DNA Damage

(2012) Madhavsai Gajjar et al.   CANCER CELL

DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis

(2012) Wynand P. Roos et al.   CANCER LETTERS

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

The Natural Anticancer Compounds Rocaglamides Inhibit the Raf-MEK-ERK Pathway by Targeting Prohibitin 1 and 2

(2012) Gernot Polier et al.   CHEMISTRY & BIOLOGY

Mdm2 and MdmX partner to regulate p53

(2012) Xinjiang Wang et al.   FEBS LETTERS

Flavaglines as Potent Anticancer and Cytoprotective Agents

(2012) Nigel Ribeiro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of Different Biomarkers to Predict Individual Radiosensitivity in an Inter-Laboratory Comparison–Lessons for Future Studies

(2012) Burkhard Greve et al.   PLoS One

The use of Chinese herbal medicine to improve quality of life in women undergoing chemotherapy for ovarian cancer: a double-blind placebo-controlled randomized trial with immunological monitoring

(2011) K. K. L. Chan et al.   ANNALS OF ONCOLOGY

Resistance and gain-of-resistance phenotypes in cancers harboring wild-type p53

(2011) Michelle Martinez-Rivera et al.   BIOCHEMICAL PHARMACOLOGY

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

(2011) Colleen A. Brady et al.   CELL

Flavaglines Alleviate Doxorubicin Cardiotoxicity: Implication of Hsp27

(2011) Yohann Bernard et al.   PLoS One

Rocaglamide breaks TRAIL resistance in HTLV-1-associated adult T-cell leukemia/lymphoma by translational suppression of c-FLIP expression

(2010) M Bleumink et al.   CELL DEATH AND DIFFERENTIATION

The Four-Herb Chinese Medicine PHY906 Reduces Chemotherapy-Induced Gastrointestinal Toxicity

(2010) W. Lam et al.   Science Translational Medicine

Rocaglamide sensitizes leukemic T cells to activation-induced cell death by differential regulation of CD95L and c-FLIP expression

(2009) J Y Zhu et al.   CELL DEATH AND DIFFERENTIATION

Mdm2-mediated ubiquitylation: p53 and beyond

(2009) J-C Marine et al.   CELL DEATH AND DIFFERENTIATION

The multiple levels of regulation by p53 ubiquitination

(2009) J T Lee et al.   CELL DEATH AND DIFFERENTIATION

Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol

(2009) Regina Cencic et al.   PLoS One

Timed Somatic Deletion of p53 in Mice Reveals Age-Associated Differences in Tumor Progression

(2009) George Hinkal et al.   PLoS One

Tumour cell survival signalling by the ERK1/2 pathway

(2008) K Balmanno et al.   CELL DEATH AND DIFFERENTIATION

Differential effects of chemotherapeutic drugs versus the MDM-2 antagonist nutlin-3 on cell cycle progression and induction of apoptosis in SKW6.4 lymphoblastoid B-cells

(2007) Elisa Barbarotto et al.   JOURNAL OF CELLULAR BIOCHEMISTRY