Improved glucose metabolism following bariatric surgery is associated with increased circulating bile acid concentrations and remodeling of the gut microbiome

Intestinal microbiota and type 2 diabetes: From mechanism insights to therapeutic perspective

(2017) Jun-Ling Han et al.   WORLD JOURNAL OF GASTROENTEROLOGY

RecurrentClostridium difficileinfection associates with distinct bile acid and microbiome profiles

(2016) J. R. Allegretti et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Bile acids regulate intestinal cell proliferation by modulating EGFR and FXR signaling

(2016) Avafia Y. Dossa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bile Acids Increase Independently From Hypocaloric Restriction After Bariatric Surgery

(2016) Cyrus Jahansouz et al.   ANNALS OF SURGERY

Perioperative Glycemic Management of Patients Undergoing Bariatric Surgery

(2016) David Rometo et al.   Current Diabetes Reports

Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations

(2016) Francesco Rubino et al.   DIABETES CARE

Blockade of Sphingosine 1-Phosphate Receptor 2 Signaling Attenuates High-Fat Diet-Induced Adipocyte Hypertrophy and Systemic Glucose Intolerance in Mice

(2016) Yoshihiko Kitada et al.   ENDOCRINOLOGY

Comparative Effects of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Glucose Homeostasis and Incretin Hormones in Obese Type 2 Diabetic Patients: A One-Year Prospective Study

(2016) G. Nosso et al.   HORMONE AND METABOLIC RESEARCH

Influence of Roux-en-Y gastric bypass on plasma bile acid profiles: a comparative study between rats, pigs and humans

(2016) V Spinelli et al.   INTERNATIONAL JOURNAL OF OBESITY

The role of bile acids in metabolic regulation

(2016) Libor Vítek et al.   JOURNAL OF ENDOCRINOLOGY

Ursodeoxycholic acid after bile duct stone removal and risk factors for recurrence: a randomized trial

(2016) Ryuichi Yamamoto et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Metabolomics Study of Roux-en-Y Gastric Bypass Surgery (RYGB) to Treat Type 2 Diabetes Patients Based on Ultraperformance Liquid Chromatography–Mass Spectrometry

(2016) Ping Luo et al.   JOURNAL OF PROTEOME RESEARCH

Ursodeoxycholic acid and 4-phenylbutyrate prevent endoplasmic reticulum stress-induced podocyte apoptosis in diabetic nephropathy

(2016) Ai-Li Cao et al.   LABORATORY INVESTIGATION

The bile acid TUDCA increases glucose-induced insulin secretion via the cAMP/PKA pathway in pancreatic beta cells

(2016) Jean Franciesco Vettorazzi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

(2016) Rachel J. Perry et al.   NATURE

Serum Leptin and Adiponectin Concentration in Type 2 Diabetes Patients in the Short and Long Term Following Biliopancreatic Diversion

(2016) Gian Franco Adami et al.   OBESITY SURGERY

Short- and Long-Term Effects of Weight Loss on the Complement Component C3 After Laparoscopic Gastric Bypass in Obese Patients

(2016) Segundo Á. Gómez-Abril et al.   OBESITY SURGERY

Early effect of Roux-en-Y gastric bypass on insulin sensitivity and signaling

(2016) Anna Severino et al.   Surgery for Obesity and Related Diseases

Gut Microbiota and Metabolic Health: The Potential Beneficial Effects of a Medium Chain Triglyceride Diet in Obese Individuals

(2016) Sabri Rial et al.   Nutrients

Therapeutic targeting of bile acids

(2015) Michael Camilleri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Islet β-cell failure in type 2 diabetes – Within the network of toxic lipids

(2015) Justyna Janikiewicz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

(2015) Caleb J. Kelly et al.   Cell Host & Microbe

MAFG Is a Transcriptional Repressor of Bile Acid Synthesis and Metabolism

(2015) Thomas Q. de Aguiar Vallim et al.   Cell Metabolism

Long-term effects of Roux-en-Y gastric bypass on postprandial plasma lipid and bile acids kinetics in female non diabetic subjects: A cross-sectional pilot study

(2015) Sara De Giorgi et al.   CLINICAL NUTRITION

Bariatric Surgery: Prevalence, Predictors, and Mechanisms of Diabetes Remission

(2015) George Argyropoulos   Current Diabetes Reports

Bile acids as metabolic regulators

(2015) Tiangang Li et al.   CURRENT OPINION IN GASTROENTEROLOGY

Increased Bile Acid Synthesis and Deconjugation After Biliopancreatic Diversion

(2015) Ele Ferrannini et al.   DIABETES

Role of FXR in β-Cells of Lean and Obese Mice

(2015) Björn Schittenhelm et al.   ENDOCRINOLOGY

Effects of RYGB on energy expenditure, appetite and glycaemic control: a randomized controlled clinical trial

(2015) J B Schmidt et al.   INTERNATIONAL JOURNAL OF OBESITY

The role of bile acids in reducing the metabolic complications of obesity after bariatric surgery: a systematic review

(2015) N C Penney et al.   INTERNATIONAL JOURNAL OF OBESITY

Temporal changes in bile acid levels and 12α-hydroxylation after Roux-en-Y gastric bypass surgery in type 2 diabetes

(2015) R Dutia et al.   INTERNATIONAL JOURNAL OF OBESITY

Chenodeoxycholic Acid as a Potential Prognostic Marker for Roux-en-Y Gastric Bypass in Chinese Obese Patients

(2015) Haoyong Yu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Minireview: Roles of Fibroblast Growth Factors 19 and 21 in Metabolic Regulation and Chronic Diseases

(2015) Fangfang Zhang et al.   MOLECULAR ENDOCRINOLOGY

FGF 19 and Bile Acids Increase Following Roux-en-Y Gastric Bypass but Not After Medical Management in Patients with Type 2 Diabetes

(2015) Saachi Sachdev et al.   OBESITY SURGERY

Changes in Bile Acid Profile After Laparoscopic Sleeve Gastrectomy are Associated with Improvements in Metabolic Profile and Fatty Liver Disease

(2015) Ajay P. Belgaumkar et al.   OBESITY SURGERY

A Systematic Review and Meta-analysis of the Effect of Gastric Bypass Surgery on Plasma Lipid Levels

(2015) Kirstin A. Carswell et al.   OBESITY SURGERY

Randomized, Prospective Comparison of Ursodeoxycholic Acid for the Prevention of Gallstones after Sleeve Gastrectomy

(2015) Lindsay B. Adams et al.   OBESITY SURGERY

Effect of Roux-en-Y Gastric Bypass Surgery on Bile Acid Metabolism in Normal and Obese Diabetic Rats

(2015) Hina Y Bhutta et al.   PLoS One

Should metabolic surgery be offered in morbidly obese patients with type I diabetes?

(2015) Maud Robert et al.   Surgery for Obesity and Related Diseases

Bile Acid-Activated Receptors, Intestinal Microbiota, and the Treatment of Metabolic Disorders

(2015) Stefano Fiorucci et al.   TRENDS IN MOLECULAR MEDICINE

A prospective evaluation of the influence of three bariatric procedures on insulin resistance improvement. Should the extent of undiluted bile transit be considered a key postoperative factor altering glucose metabolism?

(2015) Łukasz Kaska et al.   Videosurgery and Other Miniinvasive Techniques

The Interplay of the Gut Microbiome, Bile Acids, and Volatile Organic Compounds

(2015) Nidhi M. Sagar et al.   Gastroenterology Research and Practice

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

(2015) Mohamed-Sami Trabelsi et al.   Nature Communications

A prospective evaluation of the influence of three bariatric procedures on insulin resistance improvement. Should the extent of undiluted bile transit be considered a key postoperative factor altering glucose metabolism?

(2015) Łukasz Kaska et al.   Videosurgery and Other Miniinvasive Techniques

Gut Microbiota and Metabolic Disorders

(2015) Kyu Yeon Hur et al.   Diabetes & Metabolism Journal

Metabolic surgery: Action via hormonal milieu changes, changes in bile acids or gut microbiota? A summary of the literature

(2014) Timothy E. Sweeney et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

The Relationship Between Specific Fatty Acids of Serum Lipids and Serum High Sensitivity C- Reactive Protein Levels in Morbidly Obese Women

(2014) Lukasz Kaska et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Effects of Gastrointestinal Surgery on Gut Microbiota: Potential Contribution to Improved Insulin Sensitivity

(2014) Judith Aron-Wisnewsky et al.   Current Atherosclerosis Reports

Bile Acid Sequestrants: Glucose-Lowering Mechanisms and Efficacy in Type 2 Diabetes

(2014) Morten Hansen et al.   Current Diabetes Reports

Gut microbiota composition and its effects on obesity and insulin resistance

(2014) Andrea M. Caricilli et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Bile acids and the gut microbiome

(2014) Jason M. Ridlon et al.   CURRENT OPINION IN GASTROENTEROLOGY

Short-Chain Fatty Acid Receptor and Its Contribution to Glucagon-Like Peptide-1 Release

(2014) Izumi Kaji et al.   DIGESTION

Improvements in the metabolic milieu following Roux-en-Y gastric bypass and the arrest of diabetic kidney disease

(2014) Neil G. Docherty et al.   EXPERIMENTAL PHYSIOLOGY

Intestinal transport and metabolism of bile acids

(2014) Paul A. Dawson et al.   JOURNAL OF LIPID RESEARCH

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2014) Marie Ng et al.   LANCET

FXR is a molecular target for the effects of vertical sleeve gastrectomy

(2014) Karen K. Ryan et al.   NATURE

FXR: the key to benefits in bariatric surgery?

(2014) Folkert Kuipers et al.   NATURE MEDICINE

Bile acids are nutrient signaling hormones

(2014) Huiping Zhou et al.   STEROIDS

Obesity, fatty liver disease and intestinal microbiota

(2014) Nur Arslan   WORLD JOURNAL OF GASTROENTEROLOGY

Coordinated Actions of FXR and LXR in Metabolism: From Pathogenesis to Pharmacological Targets for Type 2 Diabetes

(2014) Lin Ding et al.   International Journal of Endocrinology

A Gut Feeling to Cure Diabetes: Potential Mechanisms of Diabetes Remission after Bariatric Surgery

(2014) Young Min Cho   Diabetes & Metabolism Journal

Gut microbiota after gastric bypass in human obesity: increased richness and associations of bacterial genera with adipose tissue genes

(2013) Ling-Chun Kong et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Genetic Control of Obesity and Gut Microbiota Composition in Response to High-Fat, High-Sucrose Diet in Mice

(2013) Brian W. Parks et al.   Cell Metabolism

Ursodeoxycholic Acid and Diets Higher in Fat Prevent Gallbladder Stones During Weight Loss: A Meta-analysis of Randomized Controlled Trials

(2013) Caroline S. Stokes et al.   Clinical Gastroenterology and Hepatology

Gut microbiota and non-alcoholic fatty liver disease: new insights

(2013) J. Aron-Wisnewsky et al.   CLINICAL MICROBIOLOGY AND INFECTION

Gastrointestinal changes after bariatric surgery

(2013) I. Quercia et al.   DIABETES & METABOLISM

A Role for Fibroblast Growth Factor 19 and Bile Acids in Diabetes Remission After Roux-en-Y Gastric Bypass

(2013) G. S. Gerhard et al.   DIABETES CARE

A Surgical Model in Male Obese Rats Uncovers Protective Effects of Bile Acids Post-Bariatric Surgery

(2013) Rohit Kohli et al.   ENDOCRINOLOGY

Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding

(2013) Samantha Scholtz et al.   GUT

Roux-en-Y gastric bypass normalizes the blunted postprandial bile acid excursion associated with obesity

(2013) N N Ahmad et al.   INTERNATIONAL JOURNAL OF OBESITY

Weight Loss Induced by Roux-en-Y Gastric Bypass But Not Laparoscopic Adjustable Gastric Banding Increases Circulating Bile Acids

(2013) Rohit Kohli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

The bile acid membrane receptor TGR5: a novel pharmacological target in metabolic, inflammatory and neoplastic disorders

(2013) Vanesa Stepanov et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Gut metagenome in European women with normal, impaired and diabetic glucose control

(2013) Fredrik H. Karlsson et al.   NATURE

Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner

(2013) Andriy Myronovych et al.   Obesity

Laparoscopic sleeve gastrectomy differentially affects serum concentrations of FGF-19 and FGF-21 in morbidly obese subjects

(2013) D. Haluzíková et al.   Obesity

Bile acids and gut peptide secretion after bariatric surgery: A 1-year prospective randomized pilot trial

(2013) Robert E. Steinert et al.   Obesity

Roux-en-Y gastric bypass surgery in rats alters gut microbiota profile along the intestine

(2013) Melania Osto et al.   PHYSIOLOGY & BEHAVIOR

Enhanced fasting and post-prandial plasma bile acid responses after Roux-en-Y gastric bypass surgery

(2013) Malin Werling et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Conserved Shifts in the Gut Microbiota Due to Gastric Bypass Reduce Host Weight and Adiposity

(2013) A. P. Liou et al.   Science Translational Medicine

Microbial Biotransformations of Bile Acids as Detected by Electrospray Mass Spectrometry

(2013) Lee R. Hagey et al.   Advances in Nutrition

Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ

(2013) Caitriona M. Guinane et al.   Therapeutic Advances in Gastroenterology

Bacteria as vitamin suppliers to their host: a gut microbiota perspective

(2012) Jean Guy LeBlanc et al.   CURRENT OPINION IN BIOTECHNOLOGY

GLP-1–Based Therapies and the Exocrine Pancreas: More Light, or Just More Heat?

(2012) Edwin A.M. Gale   DIABETES

Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers

(2012) T. E. Adrian et al.   DIABETOLOGIA

Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats

(2012) B. P. Cummings et al.   Disease Models & Mechanisms

The Role of Bile After Roux-en-Y Gastric Bypass in Promoting Weight Loss and Improving Glycaemic Control

(2012) Dimitri J. Pournaras et al.   ENDOCRINOLOGY

Bariatric surgery for type 2 diabetes

(2012) John B Dixon et al.   LANCET

FXR signaling in the enterohepatic system

(2012) Tsutomu Matsubara et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

The importance of the gut microbiota after bariatric surgery

(2012) Judith Aron-Wisnewsky et al.   Nature Reviews Gastroenterology & Hepatology

Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes

(2012) Philip R. Schauer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bariatric Surgery versus Conventional Medical Therapy for Type 2 Diabetes

(2012) Geltrude Mingrone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass

(2012) M. Simonen et al.   OBESITY SURGERY

Acute Improvement in Insulin Resistance After Laparoscopic Roux-en-Y Gastric Bypass: Is 3 Days Enough to Correct Insulin Metabolism?

(2012) Gil Faria et al.   OBESITY SURGERY

Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters

(2012) J Graessler et al.   PHARMACOGENOMICS JOURNAL

Bile acids in the colon, from healthy to cytotoxic molecules

(2012) Juan I. Barrasa et al.   TOXICOLOGY IN VITRO

Targeting xenobiotic receptors PXR and CAR for metabolic diseases

(2012) Jie Gao et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Interaction Between Obesity and the Gut Microbiota: Relevance in Nutrition

(2011) Nathalie M. Delzenne et al.   Annual Review of Nutrition

Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion

(2011) HE Parker et al.   BRITISH JOURNAL OF PHARMACOLOGY

Current evidence for a role of GLP-1 in Roux-en-Y gastric bypass-induced remission of type 2 diabetes

(2011) N. A. Rhee et al.   DIABETES OBESITY & METABOLISM

Alterations of Hormonally Active Fibroblast Growth Factors after Roux-en-Y Gastric Bypass Surgery

(2011) Peter L.M. Jansen et al.   DIGESTIVE DISEASES

Bile Acid Is a Host Factor That Regulates the Composition of the Cecal Microbiota in Rats

(2011) K.B.M. Saiful Islam et al.   GASTROENTEROLOGY

Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk

(2011) J. V. Li et al.   GUT

Bacterial degradation of bile salts

(2010) Bodo Philipp   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Differential Adaptation of Human Gut Microbiota to Bariatric Surgery-Induced Weight Loss: Links With Metabolic and Low-Grade Inflammation Markers

(2010) J.-P. Furet et al.   DIABETES

Mechanisms of early improvement / resolution of type 2 diabetes after bariatric surgery

(2010) G. Mingrone et al.   DIABETES & METABOLISM

The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain

(2010) Verena Keitel et al.   GLIA

The role of fat topology in the risk of disease

(2009) Y Matsuzawa   INTERNATIONAL JOURNAL OF OBESITY

Endocrine mechanisms mediating remission of diabetes after gastric bypass surgery

(2009) D E Cummings   INTERNATIONAL JOURNAL OF OBESITY

The Constitutive Androstane Receptor Is an Anti-obesity Nuclear Receptor That Improves Insulin Sensitivity

(2009) Jie Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid quantification of bile acids and their conjugates in serum by liquid chromatography–tandem mass spectrometry

(2009) Max Scherer et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Bile acids as regulatory molecules

(2009) Phillip B. Hylemon et al.   JOURNAL OF LIPID RESEARCH

Bile acids: regulation of synthesis

(2009) John Y. L. Chiang   JOURNAL OF LIPID RESEARCH

Effect of bile salts on the DNA and membrane integrity of enteric bacteria

(2009) M. E. Merritt et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Serum bile acid along with plasma incretins and serum high–molecular weight adiponectin levels are increased after bariatric surgery

(2009) Hiroshi Nakatani et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Serum Bile Acids Are Higher in Humans With Prior Gastric Bypass: Potential Contribution to Improved Glucose and Lipid Metabolism

(2009) Mary-Elizabeth Patti et al.   Obesity

Increased Serum Nitric Oxide Concentration After Bariatric Surgery—A Potential Mechanism for Cardiovascular Benefit

(2009) Tomasz Sledzinski et al.   OBESITY SURGERY

Human gut microbiota in obesity and after gastric bypass

(2009) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bile acid-activated receptors in the treatment of dyslipidemia and related disorders

(2009) Stefano Fiorucci et al.   PROGRESS IN LIPID RESEARCH

Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders

(2009) Stefano Fiorucci et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Impact of Obesity and Bariatric Surgery on Survival

(2009) Nicolas V. Christou   WORLD JOURNAL OF SURGERY

Fifty years of advances in bile acid synthesis and metabolism

(2008) David W. Russell   JOURNAL OF LIPID RESEARCH

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Serum Phenylalanine Concentration as a Marker of Liver Function in Obese Patients Before and After Bariatric Surgery

(2008) Julian Swierczynski et al.   OBESITY SURGERY

Endocrine and paracrine role of bile acids

(2008) Verena Keitel et al.   WORLD JOURNAL OF GASTROENTEROLOGY