The role of bile acids in metabolic regulation

Novel role of TLR4 in NAFLD development: Modulation of metabolic enzymes expression

(2015) Darkiane Fernandes Ferreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice

(2015) Yunpeng Qi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Specific inhibition of bile acid transport alters plasma lipids and GLP-1

(2015) Mats Rudling et al.   BMC Cardiovascular Disorders

Apolipoprotein M

(2015) Kun Ren et al.   CLINICA CHIMICA ACTA

Role of FXR in β-Cells of Lean and Obese Mice

(2015) Björn Schittenhelm et al.   ENDOCRINOLOGY

Farnesoid X receptor-induced lysine-specific histone demethylase reduces hepatic bile acid levels and protects the liver against bile acid toxicity

(2015) Young-Chae Kim et al.   HEPATOLOGY

Bile Acid Malabsorption in Inflammatory Bowel Disease

(2015) Libor Vítek   INFLAMMATORY BOWEL DISEASES

The role of bile acids in reducing the metabolic complications of obesity after bariatric surgery: a systematic review

(2015) N C Penney et al.   INTERNATIONAL JOURNAL OF OBESITY

The dual targeting of EGFR and ErbB2 with the inhibitor Lapatinib corrects high glucose-induced apoptosis and vascular dysfunction by opposing multiple diabetes-induced signaling changes

(2015) Ibrahim F. Benter et al.   JOURNAL OF DRUG TARGETING

Thyroid-stimulating hormone regulates hepatic bile acid homeostasis via SREBP-2/HNF-4α/CYP7A1 axis

(2015) Yongfeng Song et al.   JOURNAL OF HEPATOLOGY

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Bile acids override steatosis in farnesoid X receptor deficient mice in a model of non-alcoholic steatohepatitis

(2014) Weibin Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nuclear bile acid signaling through the farnesoid X receptor

(2014) Claire Mazuy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Bile acids and the gut microbiome

(2014) Jason M. Ridlon et al.   CURRENT OPINION IN GASTROENTEROLOGY

Effect of hyperglycaemia on muscarinic M3 receptor expression and secretory sensitivity to cholinergic receptor activation in islets

(2014) A. C. Hauge-Evans et al.   DIABETES OBESITY & METABOLISM

The bile acid TGR5 membrane receptor: From basic research to clinical application

(2014) Henri Duboc et al.   DIGESTIVE AND LIVER DISEASE

Microbiota and diabetes: an evolving relationship

(2014) Herbert Tilg et al.   GUT

The Immunomodulatory Role of Bile Acids

(2014) Sándor Sipka et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation

(2014) Alessia Perino et al.   JOURNAL OF CLINICAL INVESTIGATION

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

(2014) Changtao Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

FXR is a molecular target for the effects of vertical sleeve gastrectomy

(2014) Karen K. Ryan et al.   NATURE

Bile acids are nutrient signaling hormones

(2014) Huiping Zhou et al.   STEROIDS

Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance

(2014) Lin Jia et al.   Nature Communications

Adiposity, gut microbiota and faecal short chain fatty acids are linked in adult humans

(2014) J Fernandes et al.   Nutrition & Diabetes

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

A Surgical Model in Male Obese Rats Uncovers Protective Effects of Bile Acids Post-Bariatric Surgery

(2013) Rohit Kohli et al.   ENDOCRINOLOGY

Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

(2013) Sunder Mudaliar et al.   GASTROENTEROLOGY

Vitamin D Receptor Activation Down-regulates the Small Heterodimer Partner and Increases CYP7A1 to Lower Cholesterol

(2013) Edwin C.Y. Chow et al.   GASTROENTEROLOGY

Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia

(2013) Kirk M Habegger et al.   GUT

Transport and biological activities of bile acids

(2013) Brittnee L. Zwicker et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Weight Loss Induced by Roux-en-Y Gastric Bypass But Not Laparoscopic Adjustable Gastric Banding Increases Circulating Bile Acids

(2013) Rohit Kohli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hepatic glucose sensing is required to preserve β cell glucose competence

(2013) Pascal Seyer et al.   JOURNAL OF CLINICAL INVESTIGATION

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

Dietary intervention impact on gut microbial gene richness

(2013) Aurélie Cotillard et al.   NATURE

Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner

(2013) Andriy Myronovych et al.   Obesity

Laparoscopic sleeve gastrectomy differentially affects serum concentrations of FGF-19 and FGF-21 in morbidly obese subjects

(2013) D. Haluzíková et al.   Obesity

The Bile Acid Sensor FXR Is Required for Immune-Regulatory Activities of TLR-9 in Intestinal Inflammation

(2013) Barbara Renga et al.   PLoS One

Ursodeoxycholic Acid but Not Tauroursodeoxycholic Acid Inhibits Proliferation and Differentiation of Human Subcutaneous Adipocytes

(2013) Lucia Mališová et al.   PLoS One

Shear stress activation of nuclear receptor PXR in endothelial detoxification

(2013) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bile Acid-Mediated Control of Liver Triglycerides

(2013) Claudia Fuchs et al.   SEMINARS IN LIVER DISEASE

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

(2013) Fei Li et al.   Nature Communications

SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential

(2013) Munehiro Kitada et al.   Diabetes & Metabolism Journal

SIRT1 and energy metabolism

(2012) X. Li   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells

(2012) Divya P. Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intestinotrophic Glucagon-Like Peptide-2 (GLP-2) Activates Intestinal Gene Expression and Growth Factor-Dependent Pathways Independent of the Vasoactive Intestinal Peptide Gene in Mice

(2012) Bernardo Yusta et al.   ENDOCRINOLOGY

The Role of Bile After Roux-en-Y Gastric Bypass in Promoting Weight Loss and Improving Glycaemic Control

(2012) Dimitri J. Pournaras et al.   ENDOCRINOLOGY

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

(2012) M. J. Potthoff et al.   GENES & DEVELOPMENT

miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease

(2012) Rui E. Castro et al.   JOURNAL OF HEPATOLOGY

Fasting and Postprandial Activity of Brown Adipose Tissue in Healthy Men

(2012) A. Vrieze et al.   JOURNAL OF NUCLEAR MEDICINE

Bariatric surgery for type 2 diabetes

(2012) John B Dixon et al.   LANCET

Epigenomic regulation of bile acid metabolism: Emerging role of transcriptional cofactors

(2012) Zachary Smith et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10 −/− mice

(2012) Suzanne Devkota et al.   NATURE

Targeting xenobiotic receptors PXR and CAR for metabolic diseases

(2012) Jie Gao et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

(2012) Taoufiq Harach et al.   Scientific Reports

Constipation and Risk of Cardiovascular Disease among Postmenopausal Women

(2011) Elena Salmoirago-Blotcher et al.   AMERICAN JOURNAL OF MEDICINE

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion

(2011) HE Parker et al.   BRITISH JOURNAL OF PHARMACOLOGY

Bile Acids Regulate Cardiovascular Function

(2011) Sandeep Khurana et al.   CTS-Clinical and Translational Science

The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure

(2011) Wagner S. da-Silva et al.   FEBS LETTERS

Bile Acid Is a Host Factor That Regulates the Composition of the Cecal Microbiota in Rats

(2011) K.B.M. Saiful Islam et al.   GASTROENTEROLOGY

Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk

(2011) J. V. Li et al.   GUT

Incretin-based therapies - review of the physiology, pharmacology and emerging clinical experience

(2011) J. H. Martin et al.   INTERNAL MEDICINE JOURNAL

Plasma Bile Acids Are Associated with Energy Expenditure and Thyroid Function in Humans

(2011) Johann Ockenga et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities

(2010) Rohit Kohli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The bile acid sensor FXR regulates insulin transcription and secretion

(2010) Barbara Renga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Regulation of FXR transcriptional activity in health and disease: Emerging roles of FXR cofactors and post-translational modifications

(2010) Jongsook Kim Kemper   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Differential Adaptation of Human Gut Microbiota to Bariatric Surgery-Induced Weight Loss: Links With Metabolic and Low-Grade Inflammation Markers

(2010) J.-P. Furet et al.   DIABETES

Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down?

(2010) M. A. Nauck et al.   DIABETOLOGIA

Hypertrophic cardiomyopathy and dysregulation of cardiac energetics in a mouse model of biliary fibrosis

(2010) Moreshwar S. Desai et al.   HEPATOLOGY

Bile acid malabsorption in inflammatory bowel disease

(2010) Martin Lenicek et al.   INFLAMMATORY BOWEL DISEASES

Bariatric surgery: Mechanisms, indications and outcomes

(2010) Paul E O'Brien   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Immediate neuroendocrine signaling after partial hepatectomy through acute portal hyperpressure and cholestasis

(2010) Isabelle Doignon et al.   JOURNAL OF HEPATOLOGY

Altered Bile Acid Metabolism in Childhood Functional Constipation: Inactivation of Secretory Bile Acids by Sulfation in a Subset of Patients

(2010) Alan F Hofmann et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Plasma bile acids are not associated with energy metabolism in humans

(2010) Gemma Brufau et al.   Nutrition & Metabolism

The association of bile acid excretion and atherosclerotic coronary artery disease

(2010) Gideon Charach et al.   Therapeutic Advances in Gastroenterology

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail

(2009) D. Brasacchio et al.   DIABETES

The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity

(2009) P. Vavassori et al.   JOURNAL OF IMMUNOLOGY

Bile acids as regulatory molecules

(2009) Phillip B. Hylemon et al.   JOURNAL OF LIPID RESEARCH

FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats

(2009) Sabrina Cipriani et al.   JOURNAL OF LIPID RESEARCH

Bile acids: regulation of synthesis

(2009) John Y. L. Chiang   JOURNAL OF LIPID RESEARCH

Serum Bile Acids Are Higher in Humans With Prior Gastric Bypass: Potential Contribution to Improved Glucose and Lipid Metabolism

(2009) Mary-Elizabeth Patti et al.   Obesity

Metabolic surgery: an evolution through bariatric animal models

(2009) H. Ashrafian et al.   Obesity Reviews

Human gut microbiota in obesity and after gastric bypass

(2009) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Farnesoid X Receptor Induces GLUT4 Expression Through FXR Response Element in the GLUT4 Promoter

(2008) Hong Shen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Microbes in Gastrointestinal Health and Disease

(2008) Andrew S. Neish   GASTROENTEROLOGY

Bariatric Surgery: Risks and Rewards

(2008) Walter J. Pories   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress

(2008) Jodi M. Maglich et al.   JOURNAL OF LIPID RESEARCH

Vitamin D Receptor Activators Can Protect against Vascular Calcification

(2008) S. Mathew et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats

(2008) Ting-Ting Yang et al.   NEUROSCIENCE LETTERS

Altered bile acid metabolism in patients with constipation-predominant irritable bowel syndrome and functional constipation

(2008) Hasse Abrahamsson et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Dramatic Response to Cholestyramine in a Patient with Graves' Disease Resistant to Conventional Therapy

(2008) Arántzazu Sebastián-Ochoa et al.   THYROID

Glucagon-like peptide-1, glucose homeostasis and diabetes

(2008) Jens J. Holst et al.   TRENDS IN MOLECULAR MEDICINE