Bile Acid Sequestrants: Glucose-Lowering Mechanisms and Efficacy in Type 2 Diabetes

AACE Comprehensive Diabetes Management Algorithm 2013

(2015) Alan Garber et al.   Endocrine Practice

Colestilan decreases weight gain by enhanced NEFA incorporation in biliary lipids and fecal lipid excretion

(2013) Kanami Sugimoto-Kawabata et al.   JOURNAL OF LIPID RESEARCH

The combination of colesevelam with sitagliptin enhances glycemic control in diabetic ZDF rat model

(2012) Quan Shang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice

(2012) Matthew J. Potthoff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells

(2012) Divya P. Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Effect of a Bile Acid Sequestrant on Glucose Metabolism in Subjects With Type 2 Diabetes

(2012) G. Smushkin et al.   DIABETES

Colesevelam Improves Oral but Not Intravenous Glucose Tolerance by a Mechanism Independent of Insulin Sensitivity and  -Cell Function

(2012) A. L. Marina et al.   DIABETES CARE

Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers

(2012) T. E. Adrian et al.   DIABETOLOGIA

Hypoglycemic effects of colestimide on type 2 diabetic patients with obesity

(2012) Tamotsu Neda et al.   ENDOCRINE JOURNAL

The Receptor TGR5 Mediates the Prokinetic Actions of Intestinal Bile Acids and Is Required for Normal Defecation in Mice

(2012) Farzad Alemi et al.   GASTROENTEROLOGY

Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease

(2012) Geoffrey Porez et al.   JOURNAL OF LIPID RESEARCH

Colestyramine slows gastric emptying of liquids and reduces appetite in healthy subjects

(2012) A. Psichas et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Bile Acid Binding Resin Improves Metabolic Control through the Induction of Energy Expenditure

(2012) Mitsuhiro Watanabe et al.   PLoS One

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

(2012) Taoufiq Harach et al.   Scientific Reports

Bile acid sequestrants

(2011) Carolien Out et al.   CURRENT OPINION IN LIPIDOLOGY

Effects of colesevelam on glucose absorption and hepatic/peripheral insulin sensitivity in patients with type 2 diabetes mellitus

(2011) R. R. Henry et al.   DIABETES OBESITY & METABOLISM

Effect of bile acid sequestrants on glucose metabolism, hepatic de novo lipogenesis, and cholesterol and bile acid kinetics in type 2 diabetes: a randomised controlled study

(2011) C. Beysen et al.   DIABETOLOGIA

Bile Acid Sequestration Reduces Plasma Glucose Levels in db/db Mice by Increasing Its Metabolic Clearance Rate

(2011) Maxi Meissner et al.   PLoS One

Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1

(2010) Quan Shang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes

(2010) Verena Keitel et al.   BIOLOGICAL CHEMISTRY

Effects of colesevelam on LDL-C, A1c and GLP-1 levels in patients with type 1 diabetes: a pilot randomized double-blind trial

(2010) S. K. Garg et al.   DIABETES OBESITY & METABOLISM

Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism

(2010) Gemma Brufau et al.   HEPATOLOGY

Bile acid sequestrants improve glycemic control in type 2 diabetes: A proposed mechanism implicating glucagon-like peptide 1 release

(2010) Alan F. Hofmann   HEPATOLOGY

Gender-dependent effect of Gpbar1 genetic deletion on the metabolic profiles of diet-induced obese mice

(2010) Galya Vassileva et al.   JOURNAL OF ENDOCRINOLOGY

The Effect of Colesevelam Hydrochloride on Insulin Sensitivity and Secretion in Patients With Type 2 Diabetes: A Pilot Study

(2010) Sherwyn L. Schwartz et al.   Metabolic Syndrome and Related Disorders

Plasma bile acids are not associated with energy metabolism in humans

(2010) Gemma Brufau et al.   Nutrition & Metabolism

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Effects of Chenodeoxycholate and a Bile Acid Sequestrant, Colesevelam, on Intestinal Transit and Bowel Function

(2009) Suwebatu T. Odunsi–Shiyanbade et al.   Clinical Gastroenterology and Hepatology

Major Lipids, Apolipoproteins, and Risk of Vascular Disease

(2009) The Emerging Risk Factors Collaboration*   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials

(2009) Kausik K Ray et al.   LANCET

Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

(2009) Philippe Lefebvre et al.   PHYSIOLOGICAL REVIEWS

Efficacy and Safety of Colesevelam in Patients With Type 2 Diabetes Mellitus and Inadequate Glycemic Control Receiving Insulin-Based Therapy

(2008) Ronald B. Goldberg   ARCHIVES OF INTERNAL MEDICINE

Colesevelam Hydrochloride Therapy in Patients With Type 2 Diabetes Mellitus Treated With Metformin

(2008) Harold E. Bays et al.   ARCHIVES OF INTERNAL MEDICINE

Expression and function of the bile acid receptor TGR5 in Kupffer cells

(2008) Verena Keitel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gpr40 Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion

(2008) S. Edfalk et al.   DIABETES

Colesevelam HCl Improves Glycemic Control and Reduces LDL Cholesterol in Patients With Inadequately Controlled Type 2 Diabetes on Sulfonylurea-Based Therapy

(2008) V. A. Fonseca et al.   DIABETES CARE