Biological function of Foot-and-mouth disease virus non-structural proteins and non-coding elements

Modeling Three-Dimensional Structural Motifs of Viral IRES

(2016) Gloria Lozano et al.   JOURNAL OF MOLECULAR BIOLOGY

Productive Entry of Foot-and-Mouth Disease Virus via Macropinocytosis Independent of Phosphatidylinositol 3-Kinase

(2016) Shi-Chong Han et al.   Scientific Reports

Viroporins: structure, function and potential as antiviral targets

(2015) Claire Scott et al.   JOURNAL OF GENERAL VIROLOGY

Comparative Proteomic Analysis of Wild-Type and SAP Domain Mutant Foot-and-Mouth Disease Virus-Infected Porcine Cells Identifies the Ubiquitin-Activating Enzyme UBE1 Required for Virus Replication

(2015) Zixiang Zhu et al.   JOURNAL OF PROTEOME RESEARCH

RNA–protein interaction methods to study viral IRES elements

(2015) Rosario Francisco-Velilla et al.   METHODS

Viroporin Activity of the Foot-and-Mouth Disease Virus Non-Structural 2B Protein

(2015) Da Ao et al.   PLoS One

Picornavirus IRES elements: RNA structure and host protein interactions

(2015) Encarnación Martínez-Salas et al.   VIRUS RESEARCH

Initiation of protein-primed picornavirus RNA synthesis

(2015) Aniko V. Paul et al.   VIRUS RESEARCH

RNA-Dependent RNA Polymerases of Picornaviruses: From the Structure to Regulatory Mechanisms

(2015) Cristina Ferrer-Orta et al.   Viruses-Basel

Structural insights into viral IRES-dependent translation mechanisms

(2015) Gloria Lozano et al.   Current Opinion in Virology

A critical role of interferon-induced protein IFP35 in the type I interferon response in cells induced by foot-and-mouth disease virus (FMDV) protein 2C

(2014) Wei Zheng et al.   ARCHIVES OF VIROLOGY

Three-dimensional structure of foot-and-mouth disease virus and its biological functions

(2014) Shi-Chong Han et al.   ARCHIVES OF VIROLOGY

Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1 

(2014) A. Hyrskyluoto et al.   HUMAN MOLECULAR GENETICS

The silent point mutations at the cleavage site of 2A/2B have no effect on the self-cleavage activity of 2A of foot-and-mouth disease virus

(2014) Zong-liang Gao et al.   INFECTION GENETICS AND EVOLUTION

MicroRNA regulation in human CD8+ T cell subsets – cytokine exposure alone drives miR-146a expression

(2014) Hilary M Sheppard et al.   Journal of Translational Medicine

Multiple microRNAs targeted to internal ribosome entry site against foot-and-mouth disease virus infection in vitro and in vivo

(2014) Yanyan Chang et al.   Virology Journal

Sequences outside that of residues 93–102 of 3A protein can contribute to the ability of foot-and-mouth disease virus (FMDV) to replicate in bovine-derived cells

(2014) Xueqing Ma et al.   VIRUS RESEARCH

Viroporins Customize Host Cells for Efficient Viral Propagation

(2013) Kristina M. Giorda et al.   DNA AND CELL BIOLOGY

Evolutionary conserved motifs constrain the RNA structure organization of picornavirus IRES

(2013) Noemí Fernández et al.   FEBS LETTERS

Crystal Structure of Enterovirus 71 RNA-Dependent RNA Polymerase Complexed with Its Protein Primer VPg: Implication for a trans Mechanism of VPg Uridylylation

(2013) C. Chen et al.   JOURNAL OF VIROLOGY

Recombinant adenovirus expression of FMDV P1-2A and 3C protein and its immune response in mice

(2013) Chunhe Guo et al.   RESEARCH IN VETERINARY SCIENCE

A partial deletion in non-structural protein 3A can attenuate foot-and-mouth disease virus in cattle

(2013) Juan M. Pacheco et al.   VIROLOGY

Enhanced IRES activity by the 3′UTR element determines the virulence of FMDV isolates

(2013) Soledad García-Nuñez et al.   VIROLOGY

Expression of Foot-and-Mouth Disease Virus Non-Structural Protein, 3D in Insect Cells and its Application in Detection of Anti-FMDV Antibodies

(2012) Rakesh Kumar et al.   Indian Journal of Virology

Foot-and-Mouth Disease Virus Nonstructural Protein 2C Interacts with Beclin1, Modulating Virus Replication

(2012) D. P. Gladue et al.   JOURNAL OF VIROLOGY

Foot-and-Mouth Disease Virus 3C Protease Cleaves NEMO To Impair Innate Immune Signaling

(2012) D. Wang et al.   JOURNAL OF VIROLOGY

Viroporins: structure and biological functions

(2012) José Luis Nieva et al.   NATURE REVIEWS MICROBIOLOGY

Gemin5 promotes IRES interaction and translation control through its C-terminal region

(2012) David Piñeiro et al.   NUCLEIC ACIDS RESEARCH

Glycyl-tRNA synthetase specifically binds to the poliovirus IRES to activate translation initiation

(2012) Dmitri E. Andreev et al.   NUCLEIC ACIDS RESEARCH

Exploring IRES Region Accessibility by Interference of Foot-and-Mouth Disease Virus Infectivity

(2012) Teodoro Fajardo et al.   PLoS One

The nuclear protein Sam68 is cleaved by the FMDV 3C protease redistributing Sam68 to the cytoplasm during FMDV infection of host cells

(2012) Paul Lawrence et al.   VIROLOGY

A critical role of N-myc and STAT interactor (Nmi) in foot-and-mouth disease virus (FMDV) 2C-induced apoptosis

(2012) Jianchang Wang et al.   VIRUS RESEARCH

The structures of nonprotein-coding RNAs that drive internal ribosome entry site function

(2012) Terra-Dawn M. Plank et al.   Wiley Interdisciplinary Reviews-RNA

Foot and mouth disease leader protease (Lbpro): Investigation of prime side specificity allows the synthesis of a potent inhibitor

(2011) Jorge Alexandre Nogueira Santos et al.   BIOCHIMIE

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

The Leader Proteinase of Foot-and-Mouth Disease Virus Negatively Regulates the Type I Interferon Pathway by Acting as a Viral Deubiquitinase

(2011) D. Wang et al.   JOURNAL OF VIROLOGY

Foot-and-mouth disease virus (FMDV) leader proteinase negatively regulates the porcine interferon-λ1 pathway

(2011) Dang Wang et al.   MOLECULAR IMMUNOLOGY

2A peptides provide distinct solutions to driving stop-carry on translational recoding

(2011) Pamila Sharma et al.   NUCLEIC ACIDS RESEARCH

Common conformational changes induced in type 2 picornavirus IRESs by cognate trans-acting factors

(2011) Y. Yu et al.   NUCLEIC ACIDS RESEARCH

Structural basis for the biological relevance of the invariant apical stem in IRES-mediated translation

(2011) Noemí Fernández et al.   NUCLEIC ACIDS RESEARCH

Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced RANTES transcription in PK-15 cells

(2011) Dang Wang et al.   VIRUS GENES

Targeting Beclin 1 for viral subversion of macroautophagy

(2010) Monique Gannagé et al.   Autophagy

Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced type I interferon transcription by decreasing interferon regulatory factor 3/7 in protein levels

(2010) Dang Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Foot-and-Mouth Disease Virus 2C Is a Hexameric AAA+ Protein with a Coordinated ATP Hydrolysis Mechanism

(2010) Trevor R. Sweeney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of the major epitope regions of 2C integrated with the 3AB non-structural protein of foot-and-mouth disease virus and its potential for differentiating infected from vaccinated animals

(2010) Zengjun Lu et al.   JOURNAL OF VIROLOGICAL METHODS

Translation initiation of viral mRNAs

(2010) Marcelo López-Lastra et al.   REVIEWS IN MEDICAL VIROLOGY

A recombinant truncated FMDV 3AB protein used to better distinguish between infected and vaccinated cattle

(2010) Chunyan He et al.   VACCINE

Domain disruptions of individual 3B proteins of foot-and-mouth disease virus do not alter growth in cell culture or virulence in cattle

(2010) Juan M. Pacheco et al.   VIROLOGY

Foot-and-mouth disease virus utilizes an autophagic pathway during viral replication

(2010) Vivian O'Donnell et al.   VIROLOGY

Foot-and-Mouth Disease Virus neutralizing antibodies production induced by pcDNA3 and Sindbis virus based plasmid encoding FMDV P1-2A3C3D in swine

(2009) Daniel Dory et al.   ANTIVIRAL RESEARCH

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Ubiquitination, Ubiquitin-like Modifiers, and Deubiquitination in Viral Infection

(2009) Marisa K. Isaacson et al.   Cell Host & Microbe

Nmi (N-Myc interactor) inhibits Wnt/β-catenin signaling and retards tumor growth

(2009) Rebecca A. Fillmore et al.   INTERNATIONAL JOURNAL OF CANCER

Poliovirus 2C Protein Forms Homo-oligomeric Structures Required for ATPase Activity

(2009) Peter Adams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into Cleavage Specificity from the Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease Complexed with a Peptide Substrate

(2009) Patricia A. Zunszain et al.   JOURNAL OF MOLECULAR BIOLOGY

Cleavage Specificity of the UL48 Deubiquitinating Protease Activity of Human Cytomegalovirus and the Growth of an Active-Site Mutant Virus in Cultured Cells

(2009) E. T. Kim et al.   JOURNAL OF VIROLOGY

Direct functional interaction of initiation factor eIF4G with type 1 internal ribosomal entry sites

(2009) S. de Breyne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of ubiquitination in pattern-recognition receptors and type I interferon receptor signaling

(2008) Annie Bibeau-Poirier et al.   CYTOKINE

Understanding the molecular epidemiology of foot-and-mouth-disease virus

(2008) Joern Klein   INFECTION GENETICS AND EVOLUTION

The Crystal Structure of Coxsackievirus B3 RNA-Dependent RNA Polymerase in Complex with Its Protein Primer VPg Confirms the Existence of a Second VPg Binding Site on Picornaviridae Polymerases

(2008) A. Gruez et al.   JOURNAL OF VIROLOGY

A Conserved Domain in the Leader Proteinase of Foot-and-Mouth Disease Virus Is Required for Proper Subcellular Localization and Function

(2008) T. de los Santos et al.   JOURNAL OF VIROLOGY

Far upstream element binding protein 2 interacts with enterovirus 71 internal ribosomal entry site and negatively regulates viral translation

(2008) Jing-Yi Lin et al.   NUCLEIC ACIDS RESEARCH

The impact of RNA structure on picornavirus IRES activity

(2008) Encarnación Martínez-Salas   TRENDS IN MICROBIOLOGY

Susceptibility to viral infection is enhanced by stable expression of 3A or 3AB proteins from foot-and-mouth disease virus

(2008) María F. Rosas et al.   VIROLOGY

Nucleosome destabilization in the epigenetic regulation of gene expression

(2007) Steven Henikoff   NATURE REVIEWS GENETICS