RNA binding to APOBEC deaminases; Not simply a substrate for C to U editing

APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma

(2016) B. Leonard et al.   CLINICAL CANCER RESEARCH

Rapid and dynamic transcriptome regulation by RNA editing and RNA modifications

(2016) Konstantin Licht et al.   JOURNAL OF CELL BIOLOGY

The in vitro Biochemical Characterization of an HIV-1 Restriction Factor APOBEC3F: Importance of Loop 7 on Both CD1 and CD2 for DNA Binding and Deamination

(2016) Qihan Chen et al.   JOURNAL OF MOLECULAR BIOLOGY

1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal Structure

(2016) Nadine M. Shaban et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural and functional assessment of APOBEC3G macromolecular complexes

(2016) Bogdan Polevoda et al.   METHODS

The APOBEC Protein Family: United by Structure, Divergent in Function

(2016) Jason D. Salter et al.   TRENDS IN BIOCHEMICAL SCIENCES

DNA Editing by APOBECs: A Genomic Preserver and Transformer

(2016) Binyamin A. Knisbacher et al.   TRENDS IN GENETICS

The emerging role of long non-coding RNAs in HIV infection

(2016) Daniel C. Lazar et al.   VIRUS RESEARCH

The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis

(2016) Gabriel J. Starrett et al.   Nature Communications

Crystal structures of APOBEC3G N-domain alone and its complex with DNA

(2016) Xiao Xiao et al.   Nature Communications

A Single Nucleotide Polymorphism in Human APOBEC3C Enhances Restriction of Lentiviruses

(2016) Cristina J. Wittkopp et al.   PLoS Pathogens

The RNA Binding Specificity of Human APOBEC3 Proteins Resembles That of HIV-1 Nucleocapsid

(2016) Ashley York et al.   PLoS Pathogens

Distribution of ADAT-Dependent Codons in the Human Transcriptome

(2015) Àlbert Rafels-Ybern et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Natural Polymorphisms and Oligomerization of Human APOBEC3H Contribute to Single-stranded DNA Scanning Ability

(2015) Yuqing Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain

(2015) Ke Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm

(2015) Stephen P. Methot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of the Catalytic Domain of Human APOBEC3B and the Critical Structural Role for a Conserved Methionine

(2015) Sachini U. Siriwardena et al.   JOURNAL OF MOLECULAR BIOLOGY

DNA Editing of LTR Retrotransposons Reveals the Impact of APOBECs on Vertebrate Genomes

(2015) Binyamin A. Knisbacher et al.   MOLECULAR BIOLOGY AND EVOLUTION

RNA binding to APOBEC3G induces the disassembly of functional deaminase complexes by displacing single-stranded DNA substrates

(2015) Bogdan Polevoda et al.   NUCLEIC ACIDS RESEARCH

RNA modification: the Golden Period 1995–2015

(2015) Henri Grosjean   RNA

The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization

(2015) Markus-Frederik Bohn et al.   STRUCTURE

RNA rewriting, recoding, and rewiring in human disease

(2015) Maria Anna Zipeto et al.   TRENDS IN MOLECULAR MEDICINE

APOBEC3 genes: retroviral restriction factors to cancer drivers

(2015) Stephen Henderson et al.   TRENDS IN MOLECULAR MEDICINE

RNA-binding residues in the N-terminus of APOBEC3G influence its DNA sequence specificity and retrovirus restriction efficiency

(2015) Kasandra Bélanger et al.   VIROLOGY

APOBECs and virus restriction

(2015) Reuben S. Harris et al.   VIROLOGY

Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution

(2015) S. Kasar et al.   Nature Communications

APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages

(2015) Shraddha Sharma et al.   Nature Communications

RNA editing of microRNA prevents RNA-induced silencing complex recognition of target mRNA

(2015) Yalei Cui et al.   Open Biology

Promiscuous RNA Binding Ensures Effective Encapsidation of APOBEC3 Proteins by HIV-1

(2015) Luis Apolonia et al.   PLoS Pathogens

Trypanosome RNA editing: the complexity of getting U in and taking U out

(2015) Laurie K. Read et al.   Wiley Interdisciplinary Reviews-RNA

To edit or not to edit: regulation of ADAR editing specificity and efficiency

(2015) Sarah N. Deffit et al.   Wiley Interdisciplinary Reviews-RNA

The emerging role of RNA and DNA editing in cancer

(2014) Lotta Avesson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

RNA editing, epitranscriptomics, and processing in cancer progression

(2014) Keren L Witkin et al.   CANCER BIOLOGY & THERAPY

C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47

(2014) N. Fossat et al.   EMBO REPORTS

Interaction of APOBEC3A with DNA Assessed by Atomic Force Microscopy

(2014) Luda S. Shlyakhtenko et al.   PLoS One

A DNA Sequence Recognition Loop on APOBEC3A Controls Substrate Specificity

(2014) Eric C. Logue et al.   PLoS One

Structure-Guided Analysis of the Human APOBEC3-HIV Restrictome

(2014) Halil Aydin et al.   STRUCTURE

AID and APOBEC deaminases: balancing DNA damage in epigenetics and immunity

(2014) Don-Marc Franchini et al.   Epigenomics

The multifaceted roles of RNA binding in APOBEC cytidine deaminase functions

(2014) Kimberly M. Prohaska et al.   Wiley Interdisciplinary Reviews-RNA

A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes

(2013) L. Bazak et al.   GENOME RESEARCH

ADAR Enzyme and miRNA Story: A Nucleotide that Can Make the Difference

(2013) Sara Tomaselli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Atomic force microscopy studies of APOBEC3G oligomerization and dynamics

(2013) Luda S. Shlyakhtenko et al.   JOURNAL OF STRUCTURAL BIOLOGY

Oligomerization transforms human APOBEC3G from an efficient enzyme to a slowly dissociating nucleic acid-binding protein

(2013) Kathy R. Chaurasiya et al.   Nature Chemistry

Deciphering the functions and regulation of brain-enriched A-to-I RNA editing

(2013) Jin Billy Li et al.   NATURE NEUROSCIENCE

Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity

(2013) Axel V. Horn et al.   NUCLEIC ACIDS RESEARCH

Crystal Structure of the DNA Cytosine Deaminase APOBEC3F: The Catalytically Active and HIV-1 Vif-Binding Domain

(2013) Markus-Frederik Bohn et al.   STRUCTURE

Structural determinants of HIV-1 Vif susceptibility and DNA binding in APOBEC3F

(2013) Karen K. Siu et al.   Nature Communications

NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity

(2013) In-Ja L. Byeon et al.   Nature Communications

APOBEC3G Polymorphism as a Selective Barrier to Cross-Species Transmission and Emergence of Pathogenic SIV and AIDS in a Primate Host

(2013) Annabel Krupp et al.   PLoS Pathogens

APOBEC2 Is a Monomer in Solution: Implications for APOBEC3G Models

(2012) Troy C. Krzysiak et al.   BIOCHEMISTRY

An ancient history of gene duplications, fusions and losses in the evolution of APOBEC3 mutators in mammals

(2012) Carsten Münk et al.   BMC EVOLUTIONARY BIOLOGY

Systematic identification of edited microRNAs in the human brain

(2012) S. Alon et al.   GENOME RESEARCH

Single-stranded DNA Scanning and Deamination by APOBEC3G Cytidine Deaminase at Single Molecule Resolution

(2012) Gayan Senavirathne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Evolutionary View of the Mechanism for Immune and Genome Diversity

(2012) L. Kato et al.   JOURNAL OF IMMUNOLOGY

The APOBEC3C crystal structure and the interface for HIV-1 Vif binding

(2012) Shingo Kitamura et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MODOMICS: a database of RNA modification pathways—2013 update

(2012) Magdalena A. Machnicka et al.   NUCLEIC ACIDS RESEARCH

Reduced APOBEC3H Variant Anti-Viral Activities Are Associated with Altered RNA Binding Activities

(2012) Anjie Zhen et al.   PLoS One

Transfer RNA modifications: nature's combinatorial chemistry playground

(2012) Jane E. Jackman et al.   Wiley Interdisciplinary Reviews-RNA

The ADAR protein family

(2012) Yiannis A Savva et al.   GENOME BIOLOGY

Direct evidence that RNA inhibits APOBEC3G ssDNA cytidine deaminase activity

(2011) William M. McDougall et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Translocation-Capture Sequencing Reveals the Extent and Nature of Chromosomal Rearrangements in B Lymphocytes

(2011) Isaac A. Klein et al.   CELL

Deaminase Activity on Single-stranded DNA (ssDNA) Occursin Vitrowhen APOBEC3G Cytidine Deaminase Forms Homotetramers and Higher-order Complexes

(2011) William M. McDougall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human and Rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H Demonstrate a Conserved Capacity To Restrict Vif-Deficient HIV-1

(2011) J. F. Hultquist et al.   JOURNAL OF VIROLOGY

Transcriptome-wide sequencing reveals numerous APOBEC1 mRNA-editing targets in transcript 3′ UTRs

(2011) Brad R Rosenberg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Functions and regulation of the APOBEC family of proteins

(2011) Harold C. Smith et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

APOBEC3G: a double agent in defense

(2011) Harold C. Smith   TRENDS IN BIOCHEMICAL SCIENCES

The mechanisms regulating the subcellular localization of AID

(2011) Anne-Marie Patenaude et al.   Nucleus

The dependence of Ig class-switching on the nuclear export sequence of AID likely reflects interaction with factors additional to Crm1 exportin

(2010) Julia I. Ellyard et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Structural Model for Deoxycytidine Deamination Mechanisms of the HIV-1 Inactivation Enzyme APOBEC3G

(2010) Linda Chelico et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Specific Determinants of Human APOBEC3F, APOBEC3C, and APOBEC3DE and African Green Monkey APOBEC3F That Interact with HIV-1 Vif

(2010) J. L. Smith et al.   JOURNAL OF VIROLOGY

Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction

(2010) Eric W. Refsland et al.   NUCLEIC ACIDS RESEARCH

Crystal Structure of the APOBEC3G Catalytic Domain Reveals Potential Oligomerization Interfaces

(2010) Shivender M.D. Shandilya et al.   STRUCTURE

A Hydrodynamic Analysis of APOBEC3G Reveals a Monomer−Dimer−Tetramer Self-Association That Has Implications for Anti-HIV Function

(2009) Jason D. Salter et al.   BIOCHEMISTRY

Structure, interaction and real-time monitoring of the enzymatic reaction of wild-type APOBEC3G

(2009) Ayako Furukawa et al.   EMBO JOURNAL

Deficiency in APOBEC2 Leads to a Shift in Muscle Fiber Type, Diminished Body Mass, and Myopathy

(2009) Yusuke Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Extended Structure of the APOBEC3G Catalytic Domain Suggests a Unique Holoenzyme Model

(2009) Elena Harjes et al.   JOURNAL OF MOLECULAR BIOLOGY

Functional Analysis and Structural Modeling of Human APOBEC3G Reveal the Role of Evolutionarily Conserved Elements in the Inhibition of Human Immunodeficiency Virus Type 1 Infection and Alu Transposition

(2009) Y. Bulliard et al.   JOURNAL OF VIROLOGY

Defining APOBEC3 Expression Patterns in Human Tissues and Hematopoietic Cell Subsets

(2009) F. A. Koning et al.   JOURNAL OF VIROLOGY

Mechanisms of APOBEC3G-catalyzed processive deamination of deoxycytidine on single-stranded DNA

(2009) Linda Chelico et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Editing of HIV-1 RNA by the double-stranded RNA deaminase ADAR1 stimulates viral infection

(2009) Margherita Doria et al.   NUCLEIC ACIDS RESEARCH

Definition of the interacting interfaces of Apobec3G and HIV-1 Vif using MAPPIT mutagenesis analysis

(2009) Delphine Lavens et al.   NUCLEIC ACIDS RESEARCH

Carboxy-terminal domain of AID required for its mRNA complex formation in vivo

(2009) Taichiro Nonaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Model structure of APOBEC3C reveals a binding pocket modulating ribonucleic acid interaction required for encapsidation

(2009) B. Stauch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular interactions between APOBEC3G, RNA, and HIV-1 Gag: APOBEC3G multimerization is dependent on its association with RNA

(2009) Yeshitila N Friew et al.   Retrovirology

RNA-Dependent Oligomerization of APOBEC3G Is Required for Restriction of HIV-1

(2009) Hendrik Huthoff et al.   PLoS Pathogens

Alternative splicing regulates activation-induced cytidine deaminase (AID): implications for suppression of AID mutagenic activity in normal and malignant B cells

(2008) X. Wu et al.   BLOOD

AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH Translocations

(2008) Davide F. Robbiani et al.   CELL

Sole copy of Z2-type human cytidine deaminase APOBEC3H has inhibitory activity against retrotransposons and HIV-1

(2008) Lindi Tan et al.   FASEB JOURNAL

Mouse let-7 miRNA populations exhibit RNA editing that is constrained in the 5'-seed/ cleavage/anchor regions and stabilize predicted mmu-let-7a:mRNA duplexes

(2008) J. G. Reid et al.   GENOME RESEARCH

APOBEC3G Subunits Self-associate via the C-terminal Deaminase Domain

(2008) Ryan P. Bennett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Model for Oligomeric Regulation of APOBEC3G Cytosine Deaminase-dependent Restriction of HIV

(2008) Linda Chelico et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasomal degradation restricts the nuclear lifespan of AID

(2008) Said Aoufouchi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Comparison of Cellular Ribonucleoprotein Complexes Associated with the APOBEC3F and APOBEC3G Antiviral Proteins

(2008) S. Gallois-Montbrun et al.   JOURNAL OF VIROLOGY

Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G

(2008) Kuan-Ming Chen et al.   NATURE

Erratum: A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases

(2008) Roberta Benetti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stochastic properties of processive cytidine DNA deaminases AID and APOBEC3G

(2008) L. Chelico et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Single-stranded RNA facilitates nucleocapsid: APOBEC3G complex formation

(2008) H. P. Bogerd et al.   RNA

Evidence for Restriction of Ancient Primate Gammaretroviruses by APOBEC3 but Not TRIM5α Proteins

(2008) David Perez-Caballero et al.   PLoS Pathogens

Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA

(2007) Sukhdev S. Brar et al.   DNA REPAIR

Interaction with 7SL RNA but Not with HIV-1 Genomic RNA or P Bodies Is Required for APOBEC3F Virion Packaging

(2007) Tao Wang et al.   JOURNAL OF MOLECULAR BIOLOGY