Telomere regulation in pluripotent stem cells

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Epigenetics of Reprogramming to Induced Pluripotency

(2013) Bernadett Papp et al.   CELL

Short Telomeres in ESCs Lead to Unstable Differentiation

(2013) Fabio Pucci et al.   Cell Stem Cell

Enhanced Telomere Rejuvenation in Pluripotent Cells Reprogrammed via Nuclear Transfer Relative to Induced Pluripotent Stem Cells

(2013) Rongrong Le et al.   Cell Stem Cell

Alternative lengthening of telomeres in normal mammalian somatic cells

(2013) A. A. Neumann et al.   GENES & DEVELOPMENT

Germline mutations of regulator of telomere elongation helicase 1, RTEL1, in Dyskeratosis congenita

(2013) Bari J. Ballew et al.   HUMAN GENETICS

Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease

(2013) Claudia Giachino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Telomerase-mediated telomere elongation from human blastocysts to embryonic stem cells

(2013) Sicong Zeng et al.   JOURNAL OF CELL SCIENCE

Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs

(2013) Thomas Winkler et al.   JOURNAL OF CLINICAL INVESTIGATION

PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells

(2013) Fiona T. M. Chang et al.   NUCLEIC ACIDS RESEARCH

Telomere Reprogramming and Maintenance in Porcine iPS Cells

(2013) Guangzhen Ji et al.   PLoS One

Zscan4 restores the developmental potency of embryonic stem cells

(2013) Tomokazu Amano et al.   Nature Communications

Single-Cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase

(2012) Yosef Buganim et al.   CELL

Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation

(2012) Jing Jiang et al.   CELL RESEARCH

Mitochondrial Localization of Telomeric Protein TIN2 Links Telomere Regulation to Metabolic Control

(2012) Liuh-Yow Chen et al.   MOLECULAR CELL

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Wnt/ -Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells

(2012) K. Hoffmeyer et al.   SCIENCE

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

(2012) Courtney A. Lovejoy et al.   PLoS Genetics

PML body meets telomere

(2012) Inn Chung et al.   Nucleus

Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells

(2011) Fang Wang et al.   CELL RESEARCH

Association of telomere length with authentic pluripotency of ES/iPS cells

(2011) Junjiu Huang et al.   CELL RESEARCH

Reprogramming of telomeric regions during the generation of human induced pluripotent stem cells and subsequent differentiation into fibroblast-like derivatives

(2011) Shiran Yehezkel et al.   Epigenetics

Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells

(2011) Luis F. Z. Batista et al.   NATURE

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Suv4-20h Abrogation Enhances Telomere Elongation during Reprogramming and Confers a Higher Tumorigenic Potential to iPS Cells

(2011) Rosa M. Marión et al.   PLoS One

Different telomere-length dynamics at the inner cell mass versus established embryonic stem (ES) cells

(2011) E. Varela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered Telomeres in Tumors with ATRX and DAXX Mutations

(2011) C. M. Heaphy et al.   SCIENCE

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

Distinct Epigenomic Landscapes of Pluripotent and Lineage-Committed Human Cells

(2010) R. David Hawkins et al.   Cell Stem Cell

TPP1 Is Required for TERT Recruitment, Telomere Elongation during Nuclear Reprogramming, and Normal Skin Development in Mice

(2010) Agueda M. Tejera et al.   DEVELOPMENTAL CELL

Dyskeratosis congenita

(2010) Monica Bessler et al.   FEBS LETTERS

The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3

(2010) P. Drane et al.   GENES & DEVELOPMENT

ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells

(2010) L. H. Wong et al.   GENOME RESEARCH

Zscan4 regulates telomere elongation and genomic stability in ES cells

(2010) Michal Zalzman et al.   NATURE

Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients

(2010) Suneet Agarwal et al.   NATURE

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

(2010) Mariela Jaskelioff et al.   NATURE

Alternative lengthening of telomeres: models, mechanisms and implications

(2010) Anthony J. Cesare et al.   NATURE REVIEWS GENETICS

RNAi screen for telomerase reverse transcriptase transcriptional regulators identifies HIF1  as critical for telomerase function in murine embryonic stem cells

(2010) M. Coussens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

(2010) P. W. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Krüppel-Like Transcription Factor 4 Contributes to Maintenance of Telomerase Activity in Stem Cells

(2010) Chui-Wei Wong et al.   STEM CELLS

Advances in the understanding of dyskeratosis congenita

(2009) Amanda J. Walne et al.   BRITISH JOURNAL OF HAEMATOLOGY

Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells

(2009) Rosa M. Marion et al.   Cell Stem Cell

iPS Cells Can Support Full-Term Development of Tetraploid Blastocyst-Complemented Embryos

(2009) Lan Kang et al.   Cell Stem Cell

Histone H3.3 incorporation provides a unique and functionally essential telomeric chromatin in embryonic stem cells

(2009) L. H. Wong et al.   GENOME RESEARCH

iPS cells produce viable mice through tetraploid complementation

(2009) Xiao-yang Zhao et al.   NATURE

Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells

(2009) Bo Wen et al.   NATURE GENETICS

Epigenetic Reprogramming by Somatic Cell Nuclear Transfer in Primates

(2009) Michelle Sparman et al.   STEM CELLS

The longest telomeres: a general signature of adult stem cell compartments

(2008) I. Flores et al.   GENES & DEVELOPMENT

Dissecting direct reprogramming through integrative genomic analysis

(2008) Tarjei S. Mikkelsen et al.   NATURE

A Key Role for Telomerase Reverse Transcriptase Unit in Modulating Human Embryonic Stem Cell Proliferation, Cell Cycle Dynamics, and In Vitro Differentiation

(2008) Chunbo Yang et al.   STEM CELLS

The telosome/shelterin complex and its functions

(2008) Huawei Xin et al.   GENOME BIOLOGY