P2Y1 Receptor Signaling Contributes to High Salt-Induced Priming of the NLRP3 Inflammasome in Retinal Pigment Epithelial Cells

Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells

(2016) Moritz Veltmann et al.   PLoS One

Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1  and IL-18

(2015) G. Shi et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage

(2015) Carolina Brandstetter et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Effects of dietary salt levels on monocytic cells and immune responses in healthy human subjects: a longitudinal study

(2015) Buqing Yi et al.   Translational Research

Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation

(2015) W. K. Eddie Ip et al.   Nature Communications

Decline in cellular clearance systems induces inflammasome signaling in human ARPE-19 cells

(2014) Niina Piippo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Is age-related macular degeneration a manifestation of systemic disease? New prospects for early intervention and treatment

(2014) C. M. G. Cheung et al.   JOURNAL OF INTERNAL MEDICINE

Age-Related Macular Degeneration in the Aspect of Chronic Low-Grade Inflammation (Pathophysiological ParaInflammation)

(2014) Małgorzata Nita et al.   MEDIATORS OF INFLAMMATION

Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity

(2014) B. J. Fowler et al.   SCIENCE

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

(2013) Chuan Wu et al.   NATURE

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

(2013) Markus Kleinewietfeld et al.   NATURE

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

A2E Induces IL-1ß Production in Retinal Pigment Epithelial Cells via the NLRP3 Inflammasome

(2013) Owen A. Anderson et al.   PLoS One

NLRP3 Inflammasome Blockade Inhibits VEGF-A-Induced Age-Related Macular Degeneration

(2013) Alexander G. Marneros   Cell Reports

Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells—Implications for age-related macular degeneration (AMD)

(2012) Anu Kauppinen et al.   IMMUNOLOGY LETTERS

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

(2012) Sarah L Doyle et al.   NATURE MEDICINE

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Importance of Population-Wide Sodium Reduction as a Means to Prevent Cardiovascular Disease and Stroke

(2011) Lawrence J. Appel et al.   CIRCULATION

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Involvement of xanthine oxidase and hypoxia-inducible factor 1 in Toll-like receptor 7/8-mediated activation of caspase 1 and interleukin-1β

(2010) Sally A. Nicholas et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Sodium Overload and Water Influx Activate the NALP3 Inflammasome

(2010) Christine Schorn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypertonic stress regulates T cell function via pannexin-1 hemichannels and P2X receptors

(2010) Tobias Woehrle et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents

(2009) Songcang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism

(2009) Agnes Machnik et al.   NATURE MEDICINE

Para-inflammation in the aging retina

(2009) Heping Xu et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Purinergic signaling in special senses

(2009) Gary D. Housley et al.   TRENDS IN NEUROSCIENCES