Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage
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Title
Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage
Authors
Keywords
Age-related macular degeneration, Retinal pigment epithelium, Interleukin-1β, Lysosomal membrane permeabilization, Lipid peroxidation
Journal
JOURNAL OF MOLECULAR MEDICINE-JMM
Volume 93, Issue 8, Pages 905-916
Publisher
Springer Nature
Online
2015-03-17
DOI
10.1007/s00109-015-1275-1
References
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Related references
Note: Only part of the references are listed.- Decline in cellular clearance systems induces inflammasome signaling in human ARPE-19 cells
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- Studying melanin and lipofuscin in RPE cell culture models
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- Vinpocetine inhibits amyloid-beta induced activation of NF-κB, NLRP3 inflammasome and cytokine production in retinal pigment epithelial cells
- (2014) Ruozhou Tom Liu et al. EXPERIMENTAL EYE RESEARCH
- A2E Induces IL-1ß Production in Retinal Pigment Epithelial Cells via the NLRP3 Inflammasome
- (2013) Owen A. Anderson et al. PLoS One
- Is sunlight exposure a risk factor for age-related macular degeneration? A systematic review and meta-analysis
- (2012) Guo-Yuan Sui et al. BRITISH JOURNAL OF OPHTHALMOLOGY
- DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88
- (2012) Valeria Tarallo et al. CELL
- Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells—Implications for age-related macular degeneration (AMD)
- (2012) Anu Kauppinen et al. IMMUNOLOGY LETTERS
- NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components
- (2012) Sarah L Doyle et al. NATURE MEDICINE
- Attenuation of the Lysosomal Death Pathway by Lysosomal Cholesterol Accumulation
- (2011) Hanna Appelqvist et al. AMERICAN JOURNAL OF PATHOLOGY
- Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cells
- (2010) Tim U. Krohne et al. EXPERIMENTAL EYE RESEARCH
- Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of action
- (2009) Tim U. Krohne et al. EXPERIMENTAL EYE RESEARCH
- Inflammasomes: too big to miss
- (2009) Andrea Stutz et al. JOURNAL OF CLINICAL INVESTIGATION
- Sunlight Exposure, Antioxidants, and Age-Related Macular Degeneration
- (2008) Astrid E. Fletcher ARCHIVES OF OPHTHALMOLOGY
- Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
- (2008) Veit Hornung et al. NATURE IMMUNOLOGY
- Systemic Complement Activation in Age-Related Macular Degeneration
- (2008) Hendrik P. N. Scholl et al. PLoS One
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