P4-ATPases: lipid flippases in cell membranes

Biochemical Evidence for Lead and Mercury Induced Transbilayer Movement of Phospholipids Mediated by Human Phospholipid Scramblase 1

(2013) Ashok Kumar Shettihalli et al.   CHEMICAL RESEARCH IN TOXICOLOGY

P4 ATPases: Flippases in Health and Disease

(2013) Vincent van der Mark et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Type IV P-type ATPases Distinguish Mono-versusDiacyl Phosphatidylserine Using a Cytofacial Exit Gate in the Membrane Domain

(2013) Ryan D. Baldridge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members

(2013) Jun Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sarcolipin-bound calcium pump stabilizes calcium sites exposed to the cytoplasm

(2013) Anne-Marie L. Winther et al.   NATURE

Two-gate mechanism for phospholipid selection and transport by type IV P-type ATPases

(2013) R. D. Baldridge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arl1p regulates spatial membrane organization at the trans-Golgi network through interaction with Arf-GEF Gea2p and flippase Drs2p

(2013) P.-C. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detergent-mediated incorporation of transmembrane proteins in giant unilamellar vesicles with controlled physiological contents

(2013) M. Dezi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phospholipid flippases: Building asymmetric membranes and transport vesicles

(2012) Tessy T. Sebastian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mammalian P4-ATPases and ABC transporters and their role in phospholipid transport

(2012) Jonathan A. Coleman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

P4-ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite outgrowth

(2012) Qin Xu et al.   FEBS LETTERS

Biochemical Characterization of P4-ATPase Mutations Identified in Patients with Progressive Familial Intrahepatic Cholestasis

(2012) Alex Stone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping Functional Interactions in a Heterodimeric Phospholipid Pump

(2012) Catheleyne F. Puts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role for Phospholipid Flippase Complex of ATP8A1 and CDC50A Proteins in Cell Migration

(2012) Utako Kato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylserine Stimulation of Drs2p·Cdc50p Lipid Translocase Dephosphorylation Is Controlled by Phosphatidylinositol-4-phosphate

(2012) Aurore Jacquot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipid Flippases Lem3p-Dnf1p and Lem3p-Dnf2p Are Involved in the Sorting of the Tryptophan Permease Tat2p in Yeast

(2012) Takeru Hachiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flippase-mediated phospholipid asymmetry promotes fast Cdc42 recycling in dynamic maintenance of cell polarity

(2012) Arupratan Das et al.   NATURE CELL BIOLOGY

A Putative Plant Aminophospholipid Flippase, the Arabidopsis P4 ATPase ALA1, Localizes to the Plasma Membrane following Association with a β-Subunit

(2012) Rosa L. López-Marqués et al.   PLoS One

Critical role of a transmembrane lysine in aminophospholipid transport by mammalian photoreceptor P4-ATPase ATP8A2

(2012) J. A. Coleman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of residues defining phospholipid flippase substrate specificity of type IV P-type ATPases

(2012) R. D. Baldridge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering a Prostate-Specific Membrane Antigen-Activated Tumor Endothelial Cell Prodrug for Cancer Therapy

(2012) S. R. Denmeade et al.   Science Translational Medicine

P-Type ATPases

(2011) Michael G. Palmgren et al.   Annual Review of Biophysics

The P4-ATPase TAT-5 Inhibits the Budding of Extracellular Vesicles in C. elegans Embryos

(2011) Ann M. Wehman et al.   CURRENT BIOLOGY

ATP9B, a P4-ATPase (a Putative Aminophospholipid Translocase), Localizes to thetrans-Golgi Network in a CDC50 Protein-independent Manner

(2011) Hiroyuki Takatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Role of the β-Subunit CDC50A in the Stable Expression, Assembly, Subcellular Localization, and Lipid Transport Activity of the P4-ATPase ATP8A2

(2011) Jonathan A. Coleman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P-type ATPases at a glance

(2011) M. Bublitz et al.   JOURNAL OF CELL SCIENCE

Human TMEM30a Promotes Uptake of Antitumor and Bioactive Choline Phospholipids into Mammalian Cells

(2011) R. Chen et al.   JOURNAL OF IMMUNOLOGY

Atp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus-dependent learning

(2011) Kelly Levano et al.   JOURNAL OF NEUROCHEMISTRY

Oriented Reconstitution of a Membrane Protein in a Giant Unilamellar Vesicle: Experimental Verification with the Potassium Channel KcsA

(2011) Miho Yanagisawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes

(2011) Mehmet Yabas et al.   NATURE IMMUNOLOGY

The flip side of cardiolipin import

(2011) Coen C Paulusma et al.   NATURE MEDICINE

A flippase-independent function of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1, is required for apical protein expression and microvillus formation in polarized epithelial cells

(2010) Patricia M. Verhulst et al.   HEPATOLOGY

Critical Roles of Hydrophobicity and Orientation of Side Chains for Inactivation of Sarcoplasmic Reticulum Ca2+-ATPase with Thapsigargin and Thapsigargin Analogs

(2010) Anne-Marie L. Winther et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heteromeric Interactions Required for Abundance and Subcellular Localization of Human CDC50 Proteins and Class 1 P4-ATPases

(2010) Lieke M. van der Velden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CDC50 Proteins Are Critical Components of the Human Class-1 P4-ATPase Transport Machinery

(2010) Susanne Bryde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular Targeting Signals and Lipid Specificity Determinants of the ALA/ALIS P4-ATPase Complex Reside in the Catalytic ALA α-Subunit

(2010) Rosa L. López-Marqués et al.   MOLECULAR BIOLOGY OF THE CELL

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

Dynamic regulation of cardiolipin by the lipid pump Atp8b1 determines the severity of lung injury in experimental pneumonia

(2010) Nancy B Ray et al.   NATURE MEDICINE

Disruption of the Lipid-Transporting LdMT-LdRos3 Complex in Leishmania donovani Affects Membrane Lipid Asymmetry but Not Host Cell Invasion

(2010) Adrien Weingärtner et al.   PLoS One

Oligomeric Dop1p is Part of the Endosomal Neo1p-Ysl2p-Arl1p Membrane Remodeling Complex

(2010) Sónia Barbosa et al.   TRAFFIC

Endocytic Sorting and Recycling Require Membrane Phosphatidylserine Asymmetry Maintained by TAT-1/CHAT-1

(2010) Baohui Chen et al.   PLoS Genetics

Mechanism and significance of P4 ATPase-catalyzed lipid transport: Lessons from a Na+/K+-pump

(2009) Catheleyne F. Puts et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Asymmetrical stress generated by the erythrocyte lipid flippase triggers multiple bud formation on the surface of spherical giant liposomes

(2009) Pierre Ezanno et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Localization, Purification, and Functional Reconstitution of the P4-ATPase Atp8a2, a Phosphatidylserine Flippase in Photoreceptor Disc Membranes

(2009) Jonathan A. Coleman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdc50p Plays a Vital Role in the ATPase Reaction Cycle of the Putative Aminophospholipid Transporter Drs2p

(2009) Guillaume Lenoir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a novel mouse P4-ATPase family member highly expressed during spermatogenesis

(2009) P. Xu et al.   JOURNAL OF CELL SCIENCE

A P4-ATPase Protein Interaction Network Reveals a Link between Aminophospholipid Transport and Phosphoinositide Metabolism

(2009) Catheleyne F. Puts et al.   JOURNAL OF PROTEOME RESEARCH

Regulation of a Golgi flippase by phosphoinositides and an ArfGEF

(2009) Paramasivam Natarajan et al.   NATURE CELL BIOLOGY

ATP8B1 is essential for maintaining normal hearing

(2009) J. M. Stapelbroek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstitution of phospholipid translocase activity with purified Drs2p, a type-IV P-type ATPase from budding yeast

(2009) X. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flippases: still more questions than answers

(2008) L. R. Poulsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Putative Aminophospholipid Translocases,DNF1andDNF2, Are Not Required for 7-Nitrobenz-2-oxa-1,3-diazol-4-yl-phosphatidylserine Flip across the Plasma Membrane ofSaccharomyces cerevisiae

(2008) Haley C. Stevens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Rim101 Pathway Is Involved in Rsb1 Expression Induced by Altered Lipid Asymmetry

(2008) Mika Ikeda et al.   MOLECULAR BIOLOGY OF THE CELL

Protein Kinases Fpk1p and Fpk2p are Novel Regulators of Phospholipid Asymmetry

(2008) Kenzi Nakano et al.   MOLECULAR BIOLOGY OF THE CELL

P4-ATPase Requirement for AP-1/Clathrin Function in Protein Transport from the trans-Golgi Network and Early Endosomes

(2008) Ke Liu et al.   MOLECULAR BIOLOGY OF THE CELL

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Arabidopsis P4-ATPase ALA3 Localizes to the Golgi and Requires a  -Subunit to Function in Lipid Translocation and Secretory Vesicle Formation

(2008) L. R. Poulsen et al.   PLANT CELL

Role of C. elegans TAT-1 Protein in Maintaining Plasma Membrane Phosphatidylserine Asymmetry

(2008) M. Darland-Ransom et al.   SCIENCE

The C. elegans P4-ATPase TAT-1 Regulates Lysosome Biogenesis and Endocytosis

(2008) Anne-Françoise Ruaud et al.   TRAFFIC