Membrane-Active Small Molecules: Designs Inspired by Antimicrobial Peptides

Broad Spectrum Antibacterial and Antifungal Polymeric Paint Materials: Synthesis, Structure–Activity Relationship, and Membrane-Active Mode of Action

(2015) Jiaul Hoque et al.   ACS Applied Materials & Interfaces

Nylon-3 Polymers Active against Drug-Resistant Candida albicans Biofilms

(2015) Runhui Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Membrane-Active Macromolecules Resensitize NDM-1 Gram-Negative Clinical Isolates to Tetracycline Antibiotics

(2015) Divakara S. S. M. Uppu et al.   PLoS One

Comparative Mechanistic Studies of Brilacidin, Daptomycin, and the Antimicrobial Peptide LL16

(2014) Bruk Mensa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

LTX-109 Is a Novel Agent for Nasal Decolonization of Methicillin-Resistant and -Sensitive Staphylococcus aureus

(2014) Anna C. Nilsson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2

(2014) Ekaterina Gavrish et al.   CHEMISTRY & BIOLOGY

Tackling vancomycin-resistant bacteria with ‘lipophilic–vancomycin–carbohydrate conjugates’

(2014) Venkateswarlu Yarlagadda et al.   JOURNAL OF ANTIBIOTICS

Amino Acid Modified Xanthone Derivatives: Novel, Highly Promising Membrane-Active Antimicrobials for Multidrug-Resistant Gram-Positive Bacterial Infections

(2014) Jun-Jie Koh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Membrane Active Phenylalanine Conjugated Lipophilic Norspermidine Derivatives with Selective Antibacterial Activity

(2014) Mohini M. Konai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Membrane Active Vancomycin Analogues: A Strategy to Combat Bacterial Resistance

(2014) Venkateswarlu Yarlagadda et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small Molecular Antibacterial Peptoid Mimics: The Simpler the Better!

(2014) Chandradhish Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure–Activity Relationships among Antifungal Nylon-3 Polymers: Identification of Materials Active against Drug-Resistant Strains of Candida albicans

(2014) Runhui Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Screening Nylon-3 Polymers, a New Class of Cationic Amphiphiles, for siRNA Delivery

(2014) Venkatareddy Nadithe et al.   MOLECULAR PHARMACEUTICS

Small cationic antimicrobial peptides delocalize peripheral membrane proteins

(2014) M. Wenzel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptide design for antimicrobial and immunomodulatory applications

(2013) Evan F. Haney et al.   BIOPOLYMERS

A high-throughput screen for antibiotic drug discovery

(2013) Thomas C. Scanlon et al.   BIOTECHNOLOGY AND BIOENGINEERING

Polymers with tunable side-chain amphiphilicity as non-hemolytic antibacterial agents

(2013) Divakara S. S. M. Uppu et al.   CHEMICAL COMMUNICATIONS

10 x '20 Progress--Development of New Drugs Active Against Gram-Negative Bacilli: An Update From the Infectious Diseases Society of America

(2013) H. W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Antibiotics in the clinical pipeline in 2013

(2013) Mark S Butler et al.   JOURNAL OF ANTIBIOTICS

Design and Synthesis of Amphiphilic Xanthone-Based, Membrane-Targeting Antimicrobials with Improved Membrane Selectivity

(2013) Hanxun Zou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antimicrobial peptides stage a comeback

(2013) Jeffrey L Fox   NATURE BIOTECHNOLOGY

Immune modulation by multifaceted cationic host defense (antimicrobial) peptides

(2013) Ashley L Hilchie et al.   Nature Chemical Biology

Platforms for antibiotic discovery

(2013) Kim Lewis   NATURE REVIEWS DRUG DISCOVERY

The Synthetic Amphipathic Peptidomimetic LTX109 Is a Potent Fungicide That Disturbs Plasma Membrane Integrity in a Sphingolipid Dependent Manner

(2013) Rasmus Bojsen et al.   PLoS One

De Novo Design and Synthesis of Ultra-Short Peptidomimetic Antibiotics Having Dual Antimicrobial and Anti-Inflammatory Activities

(2013) Ravichandran N. Murugan et al.   PLoS One

Expedient Synthesis of SMAMPs via Click Chemistry

(2013) Tsung-hao Fu et al.   ACS Medicinal Chemistry Letters

Role of Amphiphilicity in the Design of Synthetic Mimics of Antimicrobial Peptides with Gram-Negative Activity

(2013) Hitesh D. Thaker et al.   ACS Medicinal Chemistry Letters

Turning Defense into Offense: Defensin Mimetics as Novel Antibiotics Targeting Lipid II

(2013) Kristen M. Varney et al.   PLoS Pathogens

Study of the effect of antimicrobial peptide mimic, CSA-13, on an established biofilm formed byPseudomonas aeruginosa

(2013) Carole Nagant et al.   MicrobiologyOpen

In vivo efficacy of a silicone‒cationic steroid antimicrobial coating to prevent implant-related infection

(2012) Dustin L. Williams et al.   BIOMATERIALS

Host defense peptides: An alternative as antiinfective and immunomodulatory therapeutics

(2012) Annia Alba et al.   BIOPOLYMERS

Platelet Factor 4 Activity against P. falciparum and Its Translation to Nonpeptidic Mimics as Antimalarials

(2012) Melissa S. Love et al.   Cell Host & Microbe

Identification of Synthetic Host Defense Peptide Mimics That Exert Dual Antimicrobial and Anti-Inflammatory Activities

(2012) Abhigyan Som et al.   Clinical and Vaccine Immunology

Synthetic Mimics of Antimicrobial Peptides with Immunomodulatory Responses

(2012) Hitesh D. Thaker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cleavable Cationic Antibacterial Amphiphiles: Synthesis, Mechanism of Action, and Cytotoxicities

(2012) Jiaul Hoque et al.   LANGMUIR

The global pipeline of new medicines for the control and elimination of malaria

(2012) Melinda P Anthony et al.   MALARIA JOURNAL

Emerging trends in macromolecular antimicrobials to fight multi-drug-resistant infections

(2012) Amanda C. Engler et al.   Nano Today

Recover the lost art of drug discovery

(2012) Kim Lewis   NATURE

Modulating immunity as a therapy for bacterial infections

(2012) Robert E. W. Hancock et al.   NATURE REVIEWS MICROBIOLOGY

How Staphylococcus aureus biofilms develop their characteristic structure

(2012) S. Periasamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antimicrobial polymers as synthetic mimics of host-defense peptides

(2012) Kenichi Kuroda et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Human African Trypanosomiasis Diagnosis in First-Line Health Services of Endemic Countries, a Systematic Review

(2012) Patrick Mitashi et al.   PLoS Neglected Tropical Diseases

Antimicrobial peptidomimetics: reinterpreting nature to deliver innovative therapeutics

(2012) Mariano Scorciapino   Frontiers in Immunology

Antibacterial Mechanism of Action of Arylamide Foldamers

(2011) Bruk Mensa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and antibacterial activity of some binaphthyl-supported macrocycles containing a cationic amino acid

(2011) Daniel R. Coghlan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Transmembrane Pores Formed by Human Antimicrobial Peptide LL-37

(2011) Chang-Chun Lee et al.   BIOPHYSICAL JOURNAL

Beyond natural antimicrobial peptides: multimeric peptides and other peptidomimetic approaches

(2011) Andrea Giuliani et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Non-hemolytic α-AApeptides as antimicrobial peptidomimetics

(2011) Shruti Padhee et al.   CHEMICAL COMMUNICATIONS

Recent advances in leishmaniasis treatment

(2011) Tatiana S. Tiuman et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Synthesis of Cationic Antimicrobial β2,2-Amino Acid Derivatives with Potential for Oral Administration

(2011) Terkel Hansen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthetic Mimics of Antimicrobial Peptides from Triaryl Scaffolds

(2011) Hitesh D. Thaker et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Synthetic Antimicrobial Peptidomimetic (LTX 109): Stereochemical Impact on Membrane Disruption

(2011) Johan Isaksson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biodegradable nanostructures with selective lysis of microbial membranes

(2011) Fredrik Nederberg et al.   Nature Chemistry

Examination of a synthetic benzophenone membrane-targeted antibiotic

(2011) Sunil K. Vooturi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Describing the Mechanism of Antimicrobial Peptide Action with the Interfacial Activity Model

(2010) William C. Wimley   ACS Chemical Biology

Role of the Conformational Rigidity in the Design of Biomimetic Antimicrobial Compounds

(2010) Andrey Ivankin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production

(2010) J. H. Moffatt et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Use of Ichip for High-Throughput In Situ Cultivation of "Uncultivable" Microbial Species

(2010) D. Nichols et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Probing the “Charge Cluster Mechanism” in Amphipathic Helical Cationic Antimicrobial Peptides

(2010) Raquel F. Epand et al.   BIOCHEMISTRY

Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1

(2010) John B. Bremner et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 2

(2010) John B. Bremner et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Amphipathic Helical Cationic Antimicrobial Peptides Promote Rapid Formation of Crystalline States in the Presence of Phosphatidylglycerol: Lipid Clustering in Anionic Membranes

(2010) Raquel F. Epand et al.   BIOPHYSICAL JOURNAL

Three Decades of  -Lactamase Inhibitors

(2010) S. M. Drawz et al.   CLINICAL MICROBIOLOGY REVIEWS

Designing New β-Lactams: Implications from Their Targets, Resistance Factors and Synthesizing Enzymes

(2010) Kian-Sim Goo et al.   Current Computer-Aided Drug Design

Progress and Challenges in Implementing the Research on ESKAPE Pathogens

(2010) Louis B. Rice   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Anti-Trypanosomatid Activity of Ceragenins

(2010) Diana Lara et al.   JOURNAL OF PARASITOLOGY

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

(2010) Julian G. Hurdle et al.   NATURE REVIEWS MICROBIOLOGY

De Novo Design of Antimicrobial Polymers, Foldamers, and Small Molecules: From Discovery to Practical Applications

(2009) Gregory N. Tew et al.   ACCOUNTS OF CHEMICAL RESEARCH

Binaphthyl-Based Dicationic Peptoids with Therapeutic Potential

(2009) John B. Bremner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High Potency and Broad-Spectrum Antimicrobial Peptides Synthesized via Ring-Opening Polymerization of α-Aminoacid-N-carboxyanhydrides

(2009) Chuncai Zhou et al.   BIOMACROMOLECULES

Binaphthyl scaffolded peptoids via ring-closing metathesis reactions and their anti-bacterial activities

(2009) Adel Garas et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthetic Mimics of Antimicrobial Peptides-A Versatile Ring-Opening Metathesis Polymerization Based Platform for the Synthesis of Selective Antibacterial and Cell-Penetrating Polymers

(2009) Karen Lienkamp et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ceragenins: A Class of Antiviral Compounds to Treat Orthopox Infections

(2009) Michael D. Howell et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Design, Synthesis, and Structure−Activity Relationships of Benzophenone-Based Tetraamides as Novel Antibacterial Agents

(2009) Sunil K. Vooturi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antimicrobial Activity of Small β-Peptidomimetics Based on the Pharmacophore Model of Short Cationic Antimicrobial Peptides

(2009) Terkel Hansen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Broad-Spectrum Antimicrobial Peptides by Rational Combinatorial Design and High-Throughput Screening: The Importance of Interfacial Activity

(2009) Ramesh Rathinakumar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers

(2009) S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential of immunomodulatory host defense peptides as novel anti-infectives

(2009) Donna M. Easton et al.   TRENDS IN BIOTECHNOLOGY

AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense

(2009) Yuping Lai et al.   TRENDS IN IMMUNOLOGY

Ceragenins: Cholic Acid-Based Mimics of Antimicrobial Peptides

(2008) Xin-Zhong Lai et al.   ACCOUNTS OF CHEMICAL RESEARCH

Antibacterial and Hemolytic Activities of Pyridinium Polymers as a Function of the Spatial Relationship between the Positive Charge and the Pendant Alkyl Tail

(2008) Varun Sambhy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Impact of Self-Assembly Properties on Antibacterial Activity of Short Acyl-Lysine Oligomers

(2008) H. Sarig et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimicrobial peptide mimics for improved therapeutic properties

(2008) Shahar Rotem et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Synthetic mimics of antimicrobial peptides

(2008) Abhigyan Som et al.   BIOPOLYMERS

Structure-Activity Relationships of Antibacterial Acyl-Lysine Oligomers

(2008) Inna S. Radzishevsky et al.   CHEMISTRY & BIOLOGY

Comparison of Facially Amphiphilic versus Segregated Monomers in the Design of Antibacterial Copolymers

(2008) Gregory J. Gabriel et al.   CHEMISTRY-A EUROPEAN JOURNAL

Novel anti-infectives: is host defence the answer?

(2008) Pamela Hamill et al.   CURRENT OPINION IN BIOTECHNOLOGY

Synthetic Antimicrobial Peptidomimetics with Therapeutic Potential

(2008) Bengt Erik Haug et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides

(2008) N. P. Chongsiriwatana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA