Host defense peptides: An alternative as antiinfective and immunomodulatory therapeutics

IL-17A Enhances Vitamin D3-Induced Expression of Cathelicidin Antimicrobial Peptide in Human Keratinocytes

(2014) M. Peric et al.   JOURNAL OF IMMUNOLOGY

Apoptosis-inducing antifungal peptides and proteins: Table 1

(2012) Katrijn De Brucker et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Role of Lipid II and Membrane Thickness in the Mechanism of Action of the Lantibiotic Bovicin HC5

(2011) Aline Dias Paiva et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effects on antigen-presenting cells of short-term interaction with the human host defence peptide β-defensin 2

(2011) Francesca Morgera et al.   BIOCHEMICAL JOURNAL

Human Defensin 5 Disulfide Array Mutants: Disulfide Bond Deletion Attenuates Antibacterial Activity againstStaphylococcus aureus

(2011) Yoshitha A. Wanniarachchi et al.   BIOCHEMISTRY

Transmembrane Pores Formed by Human Antimicrobial Peptide LL-37

(2011) Chang-Chun Lee et al.   BIOPHYSICAL JOURNAL

Proline-rich antimicrobial peptides: converging to a non-lytic mechanism of action

(2011) Marco Scocchi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

CpG oligodeoxynucleotide synergizes innate defense regulator peptide for enhancing the systemic and mucosal immune responses to pseudorabies attenuated virus vaccine in piglets in vivo

(2011) Ding Cao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Host Defense Peptide LL-37 Selectively Reduces Proinflammatory Macrophage Responses

(2011) K. L. Brown et al.   JOURNAL OF IMMUNOLOGY

The Human Cathelicidin, LL-37, Induces Granzyme-mediated Apoptosis in Regulatory T Cells

(2011) Jamie S. Mader et al.   JOURNAL OF IMMUNOTHERAPY

Antimicrobial Peptides: Successes, Challenges and Unanswered Questions

(2011) William C. Wimley et al.   JOURNAL OF MEMBRANE BIOLOGY

Antibiotic activities of host defense peptides: more to it than lipid bilayer perturbation

(2011) Miriam Wilmes et al.   NATURAL PRODUCT REPORTS

Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1

(2011) Bjoern O. Schroeder et al.   NATURE

Wound healing activity of the human antimicrobial peptide LL37

(2011) Reinaldo Ramos et al.   PEPTIDES

Pardaxin-induced apoptosis enhances antitumor activity in HeLa cells

(2011) Jung-Chieh Hsu et al.   PEPTIDES

Induction of TLR4-dependent CD8+ T cell immunity by murine β-defensin2 fusion protein vaccines

(2011) H.J. Park et al.   VACCINE

Modulation of interleukin-1β-induced inflammatory responses by a synthetic cationic innate defence regulator peptide, IDR-1002, in synovial fibroblasts

(2011) Emily Turner-Brannen et al.   ARTHRITIS RESEARCH & THERAPY

Describing the Mechanism of Antimicrobial Peptide Action with the Interfacial Activity Model

(2010) William C. Wimley   ACS Chemical Biology

Probing the “Charge Cluster Mechanism” in Amphipathic Helical Cationic Antimicrobial Peptides

(2010) Raquel F. Epand et al.   BIOCHEMISTRY

Amphipathic Helical Cationic Antimicrobial Peptides Promote Rapid Formation of Crystalline States in the Presence of Phosphatidylglycerol: Lipid Clustering in Anionic Membranes

(2010) Raquel F. Epand et al.   BIOPHYSICAL JOURNAL

Human β-defensin 3 has immunosuppressive activityin vitroandin vivo

(2010) Fiona Semple et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The human cathelicidin, LL-37, induces granzyme-mediated apoptosis in cytotoxic T lymphocytes

(2010) Jamie S. Mader et al.   EXPERIMENTAL CELL RESEARCH

Antimicrobial peptides from marine invertebrates as a new frontier for microbial infection control

(2010) Anselmo Jesus Otero-González et al.   FASEB JOURNAL

Functional interaction of human neutrophil peptide-1 with the cell wall precursor lipid II

(2010) Erik de Leeuw et al.   FEBS LETTERS

Evaluation of the effect of α-defensin human neutrophil peptides on neutrophil apoptosis

(2010) Nagaoka   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Insight into Invertebrate Defensin Mechanism of Action

(2010) Paulina Schmitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthetic Cationic Peptide IDR-1002 Provides Protection against Bacterial Infections through Chemokine Induction and Enhanced Leukocyte Recruitment

(2010) Anastasia Nijnik et al.   JOURNAL OF IMMUNOLOGY

Human  -Defensin 2 and 3 and Their Mouse Orthologs Induce Chemotaxis through Interaction with CCR2

(2010) J. Rohrl et al.   JOURNAL OF IMMUNOLOGY

Antimicrobial Peptides Human  -Defensins and Cathelicidin LL-37 Induce the Secretion of a Pruritogenic Cytokine IL-31 by Human Mast Cells

(2010) F. Niyonsaba et al.   JOURNAL OF IMMUNOLOGY

LysineNε-Trimethylation, a Tool for Improving the Selectivity of Antimicrobial Peptides

(2010) María Fernández-Reyes et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bacterial membrane lipids in the action of antimicrobial agents

(2010) Richard M. Epand et al.   JOURNAL OF PEPTIDE SCIENCE

Cell selectivity and anti-inflammatory activity of a Leu/Lys-rich α-helical model antimicrobial peptide and its diastereomeric peptides

(2010) Peng Wang et al.   PEPTIDES

Plectasin, a Fungal Defensin, Targets the Bacterial Cell Wall Precursor Lipid II

(2010) T. Schneider et al.   SCIENCE

Synthetic innate defence regulator peptide enhances in vivo immunostimulatory effects of CpG-ODN in newborn piglets

(2010) Ding Cao et al.   VACCINE

Influence of Antidrug Antibodies on Plectasin Efficacy and Pharmacokinetics

(2009) K. S. Brinch et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel mode of action of polybia-MPI, a novel antimicrobial peptide, in multi-drug resistant leukemic cells

(2009) Kai-rong Wang et al.   CANCER LETTERS

Impact of α-defensins1–3 on the maturation and differentiation of human monocyte-derived DCs. Concentration-dependent opposite dual effects

(2009) Marta Rodríguez-García et al.   CLINICAL IMMUNOLOGY

Selectivity of cateslytin for fungi: the role of acidic lipid-ergosterol membrane fluidity in antimicrobial action

(2009) Frantz Jean-François et al.   FASEB JOURNAL

The antifungal plant defensin RsAFP2 from radish induces apoptosis in a metacaspase independent way inCandida albicans

(2009) An M. Aerts et al.   FEBS LETTERS

Antimicrobial Peptide-induced Apoptotic Death ofLeishmaniaResults from Calcium-de pend ent, Caspase-independent Mitochondrial Toxicity

(2009) Manjusha M. Kulkarni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-transcriptional Regulation of Genes Encoding Anti-microbial Peptides inDrosophila

(2009) Aurélien Lauwers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Cathelicidin Peptide LL-37 Modulates the Effects of IFN-  on APCs

(2009) A. Nijnik et al.   JOURNAL OF IMMUNOLOGY

Human defensins activate monocyte-derived dendritic cells, promote the production of proinflammatory cytokines, and up-regulate the surface expression of CD91

(2009) Pietro Presicce et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Broad-Spectrum Antimicrobial Peptides by Rational Combinatorial Design and High-Throughput Screening: The Importance of Interfacial Activity

(2009) Ramesh Rathinakumar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The effect of C-terminal amidation on the efficacy and selectivity of antimicrobial and anticancer peptides

(2009) Sarah Rachel Dennison et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Antibiotic-Resistant Bugs in the 21st Century — A Clinical Super-Challenge

(2009) Cesar A. Arias et al.   NEW ENGLAND JOURNAL OF MEDICINE

KKKKPLFGLFFGLF: A cationic peptide designed to exert antibacterial activity

(2009) Emilie Duval et al.   PEPTIDES

AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense

(2009) Yuping Lai et al.   TRENDS IN IMMUNOLOGY

A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity

(2009) Jason Kindrachuk et al.   VACCINE

Chicken intestine defensins activated murine peripheral blood mononuclear cells through the TLR4-NF-κB pathway

(2009) YuRong Yang et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

The Antimicrobial Peptide NK-2, the Core Region of Mammalian NK-Lysin, Kills Intraerythrocytic Plasmodium falciparum

(2008) C. Gelhaus et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Lipid domains in bacterial membranes and the action of antimicrobial agents

(2008) Richard M. Epand et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Amphibian antimicrobial peptides and Protozoa: Lessons from parasites

(2008) Luis Rivas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Antimicrobial peptide mimics for improved therapeutic properties

(2008) Shahar Rotem et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Control of cell selectivity of antimicrobial peptides

(2008) Katsumi Matsuzaki   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Human Cathelicidin CAP18/LL-37 Changes Mast Cell Function toward Innate Immunity

(2008) Mino Yoshioka et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Using hydroxymethylphenoxy derivates with the SPOT technology to generate peptides with authentic C-termini

(2008) Bernhard Ay et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel anti-infectives: is host defence the answer?

(2008) Pamela Hamill et al.   CURRENT OPINION IN BIOTECHNOLOGY

Human antimicrobial peptide histatin 5 is a cell-penetrating peptide targeting mitochondrial ATP synthesis in Leishmania

(2008) Juan Román Luque-Ortega et al.   FASEB JOURNAL

Evaluation of the effect of human  -defensins on neutrophil apoptosis

(2008) I. Nagaoka et al.   INTERNATIONAL IMMUNOLOGY

VirulentShigella flexnerisubverts the host innate immune response through manipulation of antimicrobial peptide gene expression

(2008) Brice Sperandio et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A nuclear receptor-like pathway regulating multidrug resistance in fungi

(2008) Jitendra K. Thakur et al.   NATURE

Trypanocidal and leishmanicidal activities of different antimicrobial peptides (AMPs) isolated from aquatic animals

(2007) S.E. Löfgren et al.   EXPERIMENTAL PARASITOLOGY