Elementary immunology: Na+ as a regulator of immunity

Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron

(2016) Jiandong Zhang et al.   Cell Metabolism

Sodium chloride promotes pro-inflammatory macrophage polarization thereby aggravating CNS autoimmunity

(2016) Stephanie Hucke et al.   JOURNAL OF AUTOIMMUNITY

The renal microenvironment modifies dendritic cell phenotype

(2016) Federica Chessa et al.   KIDNEY INTERNATIONAL

New insights into the multidimensional concept of macrophage ontogeny, activation and function

(2016) Florent Ginhoux et al.   NATURE IMMUNOLOGY

The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis

(2016) Ido Amit et al.   NATURE IMMUNOLOGY

Tissue biology perspective on macrophages

(2016) Yasutaka Okabe et al.   NATURE IMMUNOLOGY

Decline of lymphatic vessel density and function in murine skin during aging

(2015) Sinem Karaman et al.   ANGIOGENESIS

Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation

(2015) Xiaoyan Hui et al.   Cell Metabolism

Cutaneous Na+ Storage Strengthens the Antimicrobial Barrier Function of the Skin and Boosts Macrophage-Driven Host Defense

(2015) Jonathan Jantsch et al.   Cell Metabolism

High salt primes a specific activation state of macrophages, M(Na)

(2015) Wu-Chang Zhang et al.   CELL RESEARCH

Excess aldosterone is a critical danger signal for inflammasome activation in the development of renal fibrosis in mice

(2015) Hiroyuki Kadoya et al.   FASEB JOURNAL

Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells

(2015) Amanda L. Hernandez et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of cyclooxygenase-2 in hematopoietic cells results in salt-sensitive hypertension

(2015) Ming-Zhi Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

High salt reduces the activation of IL-4– and IL-13–stimulated macrophages

(2015) Katrina J. Binger et al.   JOURNAL OF CLINICAL INVESTIGATION

TRPV4-Mediated Detection of Hyposmotic Stress by Skin Keratinocytes Activates Developmental Immunity

(2015) Jorge Galindo-Villegas et al.   JOURNAL OF IMMUNOLOGY

Immunodeficiency and Autoimmune Enterocolopathy Linked to NFAT5 Haploinsufficiency

(2015) Brigid S. Boland et al.   JOURNAL OF IMMUNOLOGY

Salt, chloride, bleach, and innate host defense

(2015) Guoshun Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Salt Accelerates Allograft Rejection through Serum- and Glucocorticoid-Regulated Kinase-1-Dependent Inhibition of Regulatory T Cells

(2015) K. Safa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Th-17 cell activation in response to high salt following acute kidney injury is associated with progressive fibrosis and attenuated by AT-1R antagonism

(2015) Purvi Mehrotra et al.   KIDNEY INTERNATIONAL

Magnetic resonance–determined sodium removal from tissue stores in hemodialysis patients

(2015) Anke Dahlmann et al.   KIDNEY INTERNATIONAL

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Balancing wobbles in the body sodium

(2015) Jens Titze et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

An update on the role of the inflammasomes in the pathogenesis of kidney diseases

(2015) Murthy N. Darisipudi et al.   PEDIATRIC NEPHROLOGY

Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation

(2015) W. K. Eddie Ip et al.   Nature Communications

A Hitchhiker’s Guide to Myeloid Cell Subsets: Practical Implementation of a Novel Mononuclear Phagocyte Classification System

(2015) Martin Guilliams et al.   Frontiers in Immunology

23Na Magnetic Resonance Imaging of the Lower Leg of Acute Heart Failure Patients during Diuretic Treatment

(2015) Matthias Hammon et al.   PLoS One

Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages

(2014) Yasutaka Okabe et al.   CELL

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

From the regulatory functions of B cells to the identification of cytokine-producing plasma cell subsets

(2014) Van Duc Dang et al.   CURRENT OPINION IN IMMUNOLOGY

The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density

(2014) K. M. Lee et al.   EMBO JOURNAL

The xanthine oxidase-NFAT5 pathway regulates macrophage activation and TLR-induced inflammatory arthritis

(2014) Nam-Hoon Kim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Osmotic surveillance mediates rapid wound closure through nucleotide release

(2014) William J. Gault et al.   JOURNAL OF CELL BIOLOGY

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

(2014) Jan Mauer et al.   NATURE IMMUNOLOGY

Neutrophils at work

(2014) William M Nauseef et al.   NATURE IMMUNOLOGY

Macrophages in cardiac homeostasis, injury responses and progenitor cell mobilisation

(2014) Alexander R. Pinto et al.   Stem Cell Research

Tissue damage control in disease tolerance

(2014) Miguel P. Soares et al.   TRENDS IN IMMUNOLOGY

Macrophages in homeostatic immune function

(2014) Jonathan Jantsch et al.   Frontiers in Physiology

Sodium accumulation is associated with disability and a progressive course in multiple sclerosis

(2013) David Paling et al.   BRAIN

Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation

(2013) Xiaoyuan Xu et al.   Cell Metabolism

PHD2 regulates arteriogenic macrophages through TIE2 signalling

(2013) Alexander Hamm et al.   EMBO Molecular Medicine

23 Na Magnetic Resonance Imaging-Determined Tissue Sodium in Healthy Subjects and Hypertensive Patients

(2013) Christoph Kopp et al.   HYPERTENSION

High Dietary Salt Intake Exacerbates Helicobacter pylori-Induced Gastric Carcinogenesis

(2013) Jennifer A. Gaddy et al.   INFECTION AND IMMUNITY

Immune cells control skin lymphatic electrolyte homeostasis and blood pressure

(2013) Helge Wiig et al.   JOURNAL OF CLINICAL INVESTIGATION

Exclusive CX3CR1 dependence of kidney DCs impacts glomerulonephritis progression

(2013) Katharina Hochheiser et al.   JOURNAL OF CLINICAL INVESTIGATION

On-site education of VEGF-recruited monocytes improves their performance as angiogenic and arteriogenic accessory cells

(2013) Inbal Avraham-Davidi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

(2013) Chuan Wu et al.   NATURE

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

(2013) Markus Kleinewietfeld et al.   NATURE

Tissue damage detection by osmotic surveillance

(2013) Balázs Enyedi et al.   NATURE CELL BIOLOGY

Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis

(2013) Nancy J. Brown   Nature Reviews Nephrology

Salt-Dependent Chemotaxis of Macrophages

(2013) Silke Müller et al.   PLoS One

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Gene expression induced by Toll-like receptors in macrophages requires the transcription factor NFAT5

(2012) Maria Buxadé et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mycobacteria and the Intraphagosomal Environment: Take It With a Pinch of Salt(s)!

(2012) Thierry Soldati et al.   TRAFFIC

Hypertonicity-enhanced TNF-α release from activated human monocytic THP-1 cells requires ERK activation

(2011) Yung-Chen Chou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

23 Na Magnetic Resonance Imaging of Tissue Sodium

(2011) Christoph Kopp et al.   HYPERTENSION

The Inflammasomes in Kidney Disease

(2011) H.-J. Anders et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis

(2011) Yukiji Takeda et al.   NATURE

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

Brain tissue sodium concentration in multiple sclerosis: a sodium imaging study at 3 tesla

(2010) M. Inglese et al.   BRAIN

Mononuclear Phagocyte System Depletion Blocks Interstitial Tonicity-Responsive Enhancer Binding Protein/Vascular Endothelial Growth Factor C Expression and Induces Salt-Sensitive Hypertension in Rats

(2010) Agnes Machnik et al.   HYPERTENSION

Memory B and memory plasma cells

(2010) Taketoshi Yoshida et al.   IMMUNOLOGICAL REVIEWS

Sodium Overload and Water Influx Activate the NALP3 Inflammasome

(2010) Christine Schorn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osmoprotective Transcription Factor NFAT5/TonEBP Modulates Nuclear Factor-κB Activity

(2010) Isabelle Roth et al.   MOLECULAR BIOLOGY OF THE CELL

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

Is inflammation a consequence of extracellular hyperosmolarity?

(2009) Laurent Schwartz et al.   Journal of Inflammation-London

Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism

(2009) Agnes Machnik et al.   NATURE MEDICINE