Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis

Aldosterone-Specific Activation of Cardiomyocyte Mineralocorticoid Receptor In Vivo

(2013) Smail Messaoudi et al.   HYPERTENSION

Sequential comparison of aldosterone synthase inhibition and mineralocorticoid blockade in patients with primary aldosteronism

(2013) Laurence Amar et al.   JOURNAL OF HYPERTENSION

Serum-Glucocorticoid Regulated Kinase 1 Regulates Alternatively Activated Macrophage Polarization Contributing to Angiotensin II–Induced Inflammation and Cardiac Fibrosis

(2012) Min Yang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Galectin-3 Mediates Aldosterone-Induced Vascular Fibrosis

(2012) Laurent Calvier et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Angiotensin II-aldosterone interaction in human coronary microarteries involves GPR30, EGFR, and endothelial NO synthase

(2012) W. W. Batenburg et al.   CARDIOVASCULAR RESEARCH

Macrophage Mineralocorticoid Receptor Signaling Plays a Key Role in Aldosterone-Independent Cardiac Fibrosis

(2012) Laura A. Bienvenu et al.   ENDOCRINOLOGY

Mitochondrial dysfunction accounts for aldosterone-induced epithelial-to-mesenchymal transition of renal proximal tubular epithelial cells

(2012) Yanggang Yuan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Aldosterone Inhibits Antifibrotic Factors in Mouse Hypertensive Heart

(2012) Feriel Azibani et al.   HYPERTENSION

Oxidative Stress Causes Mineralocorticoid Receptor Activation in Rat Cardiomyocytes

(2012) Miki Nagase et al.   HYPERTENSION

Galectin-3 in Cardiovascular Disease

(2012) David A. Morrow et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Natriuretic Peptide Receptor Guanylyl Cyclase-A Protects Podocytes from Aldosterone-Induced Glomerular Injury

(2012) Y. Ogawa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Angiotensin II- and Salt-Induced Kidney Injury through Rac1-Mediated Mineralocorticoid Receptor Activation

(2012) W. Kawarazaki et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II–induced cardiac, renal, and vascular injury

(2012) James M. Luther et al.   KIDNEY INTERNATIONAL

Reduced NO production rapidly aggravates renal function through the NF-κB/ET-1/ETA receptor pathway in DOCA–salt-induced hypertensive rats

(2012) Kimihiro Kimura et al.   LIFE SCIENCES

Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors

(2012) Amy McCurley et al.   NATURE MEDICINE

Aldosterone synthase inhibition in humans

(2012) Michel Azizi et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Epidermal Growth Factor Receptor Is Involved in Angiotensin II But Not Aldosterone/Salt-Induced Cardiac Remodelling

(2012) Smail Messaoudi et al.   PLoS One

Mitochondrial Dysfunction Mediates Aldosterone-Induced Podocyte Damage

(2011) Chunhua Zhu et al.   AMERICAN JOURNAL OF PATHOLOGY

Deletion of Cardiomyocyte Mineralocorticoid Receptor Ameliorates Adverse Remodeling After Myocardial Infarction

(2011) Daniela Fraccarollo et al.   CIRCULATION

Effects of a Novel Aldosterone Synthase Inhibitor for Treatment of Primary Hypertension

(2011) David A. Calhoun et al.   CIRCULATION

Aldosterone stimulates nuclear factor-kappa B activity and transcription of intercellular adhesion molecule-1 and connective tissue growth factor in rat mesangial cells via serum- and glucocorticoid-inducible protein kinase-1

(2011) Yoshio Terada et al.   Clinical and Experimental Nephrology

Role of mineralocorticoid action in the brain in salt-sensitive hypertension

(2011) Kenji Oki et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Mineralocorticoid Receptor Blockade in Chronic Kidney Disease

(2011) Matthew J. Volk et al.   CURRENT HYPERTENSION REPORTS

Epidermal Growth Factor Receptor Mediates the Vascular Dysfunction But Not the Remodeling Induced by Aldosterone/Salt

(2011) Violaine Griol-Charhbili et al.   HYPERTENSION

Ablation of Mineralocorticoid Receptors in Myocytes But Not in Fibroblasts Preserves Cardiac Function

(2011) Achim Lother et al.   HYPERTENSION

Aldosterone Stimulates the Cardiac Na + /H + Exchanger via Transactivation of the Epidermal Growth Factor Receptor

(2011) Verónica C. De Giusti et al.   HYPERTENSION

GPR30 Expression Is Required for the Mineralocorticoid Receptor–Independent Rapid Vascular Effects of Aldosterone

(2011) Robert Gros et al.   HYPERTENSION

T Regulatory Lymphocytes Prevent Aldosterone-Induced Vascular Injury

(2011) Daniel A. Kasal et al.   HYPERTENSION

Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor–dependent pathway

(2011) Shigeru Shibata et al.   JOURNAL OF CLINICAL INVESTIGATION

Nedd4-2 Modulates Renal Na+-Cl- Cotransporter via the Aldosterone-SGK1-Nedd4-2 Pathway

(2011) J. P. Arroyo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Relative contributions of mitochondria and NADPH oxidase to deoxycorticosterone acetate-salt hypertension in mice

(2011) Aihua Zhang et al.   KIDNEY INTERNATIONAL

Oxidation of CaMKII determines the cardiotoxic effects of aldosterone

(2011) B Julie He et al.   NATURE MEDICINE

Firewall function of the endothelial glycocalyx in the regulation of sodium homeostasis

(2011) Stefanie Korte et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Nongenomic Effects of Aldosterone on Renal Protein Expressions of pEGFR and pERK1/2 in Rat Kidney

(2010) Kittisak Sinphitukkul et al.   AMERICAN JOURNAL OF NEPHROLOGY

Inhibition and Genetic Ablation of the B7/CD28 T-Cell Costimulation Axis Prevents Experimental Hypertension

(2010) Antony Vinh et al.   CIRCULATION

Genetic Deficiency of Plasminogen Activator Inhibitor-1 Promotes Cardiac Fibrosis in Aged Mice

(2010) Asish K. Ghosh et al.   CIRCULATION

Activation of Mineralocorticoid Receptors by Exogenous Glucocorticoids and the Development of Cardiovascular Inflammatory Responses in Adrenalectomized Rats

(2010) Morag J. Young et al.   ENDOCRINOLOGY

Aldosterone Synthase Inhibition With LCI699

(2010) Laurence Amar et al.   HYPERTENSION

Placental growth factor mediates aldosterone-dependent vascular injury in mice

(2010) Iris Z. Jaffe et al.   JOURNAL OF CLINICAL INVESTIGATION

Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice

(2010) Michael G. Usher et al.   JOURNAL OF CLINICAL INVESTIGATION

FAD286, an aldosterone synthase inhibitor, reduced atherosclerosis and inflammation in apolipoprotein E-deficient mice

(2010) Aviva Gamliel-Lazarovich et al.   JOURNAL OF HYPERTENSION

Effects of mineralocorticoid receptor blockade on glucocorticoid-induced renal injury in adrenalectomized rats

(2010) Kazi Rafiq et al.   JOURNAL OF HYPERTENSION

Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms

(2010) Faiez Zannad et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aldosterone-Induced Activation of Signaling Pathways Requires Activity of Angiotensin Type 1a Receptors

(2009) Catherine A. Lemarié et al.   CIRCULATION RESEARCH

Glucocorticoids Activate Cardiac Mineralocorticoid Receptors During Experimental Myocardial Infarction

(2009) Anastasia S. Mihailidou et al.   HYPERTENSION

Deletion of Mineralocorticoid Receptors From Macrophages Protects Against Deoxycorticosterone/Salt-Induced Cardiac Fibrosis and Increased Blood Pressure

(2009) Amanda J. Rickard et al.   HYPERTENSION

Aldosterone Modulates Steroid Receptor Binding to the Endothelin-1 Gene (edn1)

(2009) Lisa R. Stow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway

(2009) David J. Rozansky et al.   JOURNAL OF CLINICAL INVESTIGATION

Aldosterone Promotes Autoimmune Damage by Enhancing Th17-Mediated Immunity

(2009) Andrés A. Herrada et al.   JOURNAL OF IMMUNOLOGY

Aldosterone-induced TGF-β1Expression is Regulated by Mitogen-Activated Protein Kinases and Activator Protein-1 in Mesangial Cells

(2009) Jeong-Sun Han et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Aldosterone activates endothelial exocytosis

(2009) Y. Jeong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mineralocorticoid Receptor Blockade Reverses Obesity-Related Changes in Expression of Adiponectin, Peroxisome Proliferator-Activated Receptor-γ, and Proinflammatory Adipokines

(2008) Christine Guo et al.   CIRCULATION

Functional Mineralocorticoid Receptors in Human Vascular Endothelial Cells Regulate Intercellular Adhesion Molecule-1 Expression and Promote Leukocyte Adhesion

(2008) Massimiliano Caprio et al.   CIRCULATION RESEARCH

Salt Excess Causes Left Ventricular Diastolic Dysfunction in Rats With Metabolic Disorder

(2008) Hiromitsu Matsui et al.   HYPERTENSION

Aldosterone Activates NF- B in the Collecting Duct

(2008) V. Leroy et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease

(2008) Shigeru Shibata et al.   NATURE MEDICINE

Variable expression of 11β Hydroxysteroid dehydrogenase (11β-HSD) isoforms in vascular endothelial cells

(2008) Rujun Gong et al.   STEROIDS

Aldosterone Induces Superoxide Generation via Rac1 Activation in Endothelial Cells

(2007) Fumiko Iwashima et al.   ENDOCRINOLOGY