Oxidative Stress and Treg and Th17 Dysfunction in Systemic Lupus Erythematosus

Function of Treg Cells Decreased in Patients With Systemic Lupus Erythematosus Due To the Effect of Prolactin

(2016) María Victoria Legorreta-Haquet et al.   MEDICINE

Lupus Nephritis IgG Induction of Calcium/Calmodulin-Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function

(2016) Kunihiro Ichinose et al.   Arthritis & Rheumatology

Calcium/Calmodulin-Dependent Kinase IV Facilitates the Recruitment of Interleukin-17-Producing Cells to Target Organs Through the CCR6/CCL20 Axis in Th17 Cell-Driven Inflammatory Diseases

(2016) Tomohiro Koga et al.   Arthritis & Rheumatology

Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition

(2016) Dohyun Park et al.   Scientific Reports

mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging

(2015) Andras Perl   Annals of the New York Academy of Sciences

Interleukin-17 in systemic lupus erythematosus: A comprehensive review

(2015) Duo Li et al.   AUTOIMMUNITY

Protective Effects of Baicalin on Aβ1–42-Induced Learning and Memory Deficit, Oxidative Stress, and Apoptosis in Rat

(2015) Haitao Ding et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Evidence for New Light-Independent Pathways for Generation of the Endogenous Aryl Hydrocarbon Receptor Agonist FICZ

(2015) Anna Smirnova et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Oxidative stress and Treg depletion in lupus patients with anti-phospholipid syndrome

(2015) Zhi-wei Lai et al.   CLINICAL IMMUNOLOGY

Ultraviolet light converts propranolol, a nonselective β-blocker and potential lupus-inducing drug, into a proinflammatory AhR ligand

(2015) Karim Dorgham et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD4+ T cells epigenetically modified by oxidative stress cause lupus-like autoimmunity in mice

(2015) Faith M. Strickland et al.   JOURNAL OF AUTOIMMUNITY

Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity

(2015) Patrick R. Burkett et al.   JOURNAL OF CLINICAL INVESTIGATION

FICZ: A Messenger of Light in Human Skin

(2015) Deeba N. Syed et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Role of altered mitochondria functions in the pathogenesis of systemic lupus erythematosus

(2015) B D Leishangthem et al.   LUPUS

Association of the interleukin-6 polymorphisms with systemic lupus erythematosus: a meta-analysis

(2015) Y X Cui et al.   LUPUS

Circulating CXCR5+CD4+helper T cells in systemic lupus erythematosus patients share phenotypic properties with germinal center follicular helper T cells and promote antibody production

(2015) X Zhang et al.   LUPUS

Comprehensive metabolome analyses reveal N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of rapamycin

(2015) Andras Perl et al.   Metabolomics

Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases

(2015) Andras Perl   Nature Reviews Rheumatology

Early-stage lupus nephritis treated with N-acetylcysteine: A report of two cases

(2015) MING LI et al.   Experimental and Therapeutic Medicine

The Aryl Hydrocarbon Receptor: Multitasking in the Immune System

(2014) Brigitta Stockinger et al.   Annual Review of Immunology

Increased Mitochondrial Electron Transport Chain Activity at Complex I Is Regulated by N-Acetylcysteine in Lymphocytes of Patients with Systemic Lupus Erythematosus

(2014) Edward Doherty et al.   ANTIOXIDANTS & REDOX SIGNALING

Impact assessment of energy-efficient lighting in patients with lupus erythematosus: a pilot study

(2014) L. Fenton et al.   BRITISH JOURNAL OF DERMATOLOGY

Photosensitivity, Apoptosis, and Cytokines in the Pathogenesis of Lupus Erythematosus: a Critical Review

(2014) Annegret Kuhn et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Metabolism of activated T lymphocytes

(2014) Jason A Maciolek et al.   CURRENT OPINION IN IMMUNOLOGY

Regulatory T cells in systemic lupus erythematosus

(2014) Kim Ohl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

mTOR signaling, Tregs and immune modulation

(2014) Nicole M Chapman et al.   Immunotherapy

Baicalin Ameliorates H2O2 Induced Cytotoxicity in HK-2 Cells through the Inhibition of ER Stress and the Activation of Nrf2 Signaling

(2014) Miao Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

mTOR Signaling in T Cell Immunity and Autoimmunity

(2014) Yu Liu et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance

(2014) Tomohiro Koga et al.   JOURNAL OF CLINICAL INVESTIGATION

Deficient Leptin Signaling Ameliorates Systemic Lupus Erythematosus Lesions in MRL/Mp-Faslpr Mice

(2014) Y. Fujita et al.   JOURNAL OF IMMUNOLOGY

Mechanistic Target of Rapamycin Complex 1 Expands Th17 and IL-4+ CD4-CD8- Double-Negative T Cells and Contracts Regulatory T Cells in Systemic Lupus Erythematosus

(2014) H. Kato et al.   JOURNAL OF IMMUNOLOGY

Ultraviolet radiation and systemic lupus erythematosus

(2014) M Barbhaiya et al.   LUPUS

Oxidative Stress, T Cell DNA Methylation, and Lupus

(2014) YePeng Li et al.   Arthritis & Rheumatology

The activation mechanism of the aryl hydrocarbon receptor (AhR) by molecular chaperone HSP90

(2014) Noriko Tsuji et al.   FEBS Open Bio

Role of PI3K/Akt and mTOR complexes in Th17 cell differentiation

(2013) Shigenori Nagai et al.   Annals of the New York Academy of Sciences

Leptin promotes lupus T-cell autoimmunity

(2013) Gil Amarilyo et al.   CLINICAL IMMUNOLOGY

Hydroxychloroquine decreases Th17-related cytokines in systemic lupus erythematosus and rheumatoid arthritis patients

(2013) JC Silva et al.   Clinics

mTOR: more targets of resveratrol?

(2013) Anne L. Widlund et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Cutting Edge: Leptin-Induced ROR t Expression in CD4+ T Cells Promotes Th17 Responses in Systemic Lupus Erythematosus

(2013) Y. Yu et al.   JOURNAL OF IMMUNOLOGY

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Oxidative stress in the pathology and treatment of systemic lupus erythematosus

(2013) Andras Perl   Nature Reviews Rheumatology

The interplay between regulatory T cells and metabolism in immune regulation

(2013) Hu Zeng et al.   OncoImmunology

N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double-blind, placebo-controlled trial

(2012) Zhi-Wei Lai et al.   ARTHRITIS AND RHEUMATISM

Baicalin, a natural compound, promotes regulatory T cell differentiation

(2012) Ji Yang et al.   BMC Complementary and Alternative Medicine

Leptin-Induced mTOR Activation Defines a Specific Molecular and Transcriptional Signature Controlling CD4+ Effector T Cell Responses

(2012) C. Procaccini et al.   JOURNAL OF IMMUNOLOGY

Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor

(2012) E. Wincent et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antroquinonol differentially modulates T cell activity and reduces interleukin-18 production, but enhances Nrf2 activation, in murine accelerated severe lupus nephritis

(2011) Pei-Yi Tsai et al.   ARTHRITIS AND RHEUMATISM

TGF-β in transplantation tolerance

(2011) Frederico S Regateiro et al.   CURRENT OPINION IN IMMUNOLOGY

Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation

(2011) Pei-Yi Tsai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cutting Edge: Calcium/Calmodulin-Dependent Protein Kinase Type IV Is Essential for Mesangial Cell Proliferation and Lupus Nephritis

(2011) K. Ichinose et al.   JOURNAL OF IMMUNOLOGY

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Identification of Baicalin as an Immunoregulatory Compound by Controlling TH17 Cell Differentiation

(2011) Ji Yang et al.   PLoS One

Recovery of the immune balance between Th17 and regulatory T cells as a treatment for systemic lupus erythematosus

(2011) J. Yang et al.   RHEUMATOLOGY

Cytochrome P450 1A1 gene regulation by UVB involves crosstalk between the aryl hydrocarbon receptor and nuclear factor κB

(2010) S. Luecke et al.   CHEMICO-BIOLOGICAL INTERACTIONS

An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness

(2010) Claudio Procaccini et al.   IMMUNITY

The Aryl Hydrocarbon Receptor Mediates UVB Radiation–Induced Skin Tanning

(2010) Bettina Jux et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Th17 and natural Treg cell population dynamics in systemic lupus erythematosus

(2009) Ji Yang et al.   ARTHRITIS AND RHEUMATISM

Systems biology of lupus: Mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance, and selecting targets for treatment

(2009) Andras Perl   AUTOIMMUNITY

Oxidative protein damage and antioxidant status in systemic lupus erythematosus

(2009) Q. Zhang et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

T-cell and B-cell signaling biomarkers and treatment targets in lupus

(2009) Andras Perl et al.   CURRENT OPINION IN RHEUMATOLOGY

Adipocytokines in systemic lupus erythematosus: relationship to inflammation, insulin resistance and coronary atherosclerosis

(2009) CP Chung et al.   LUPUS

The aryl hydrocarbon receptor in immunity

(2009) Charlotte Esser et al.   TRENDS IN IMMUNOLOGY

Reduced CD4+,CD25− T cell sensitivity to the suppressive function of CD4+,CD25high,CD127−/lowregulatory T cells in patients with active systemic lupus erythematosus

(2008) Ram Kumar Chowdary Venigalla et al.   ARTHRITIS AND RHEUMATISM

Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells

(2008) Marc Veldhoen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE