Review
Biochemistry & Molecular Biology
Monika Szelest, Katarzyna Walczak, Tomasz Plech
Summary: The aryl hydrocarbon receptor (AhR) plays a crucial role in skin physiology and pathological processes, including melanogenesis, inflammation, and cancer. Tryptophan metabolites are distinct among natural and synthetic AhR ligands, affecting various signaling pathways and expanding interest in their influence on skin physiological and pathological processes. Further investigation is needed to understand the mechanisms by which AhR regulates skin function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Ivana Mikocziova, Ayelet Peres, Moriah Gidoni, Victor Greiff, Gur Yaari, Ludvig M. Solid
Summary: The study analyzed light chain cDNA sequences from naive B cell receptor repertoires to optimize allele inference, identifying 48 previously unreported variants and validating 11 of them. Clustering of light chain sequences revealed partial intron retention in certain V alleles, providing insight into germline variation in human light chain immunoglobulin loci.
Article
Chemistry, Multidisciplinary
Anna K. Blakney, Polina Deletic, Paul F. McKay, Clement R. Bouton, Marianne Ashford, Robin J. Shattock, Alan Sabirsh
Summary: This study explores the effects of different lipid formulations on mRNA uptake and expression in human skin explants, finding that adipocytes efficiently express mRNA and contribute significantly to total RNA-encoded protein expression. Other cell types also increase mRNA expression over 72 hours, regardless of lipid formulation. The overall charge of particles, rather than the lipid classification, predicts the pattern of mRNA uptake and expression among resident cell types.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Panagiotis Kallimanis, Ioanna Chinou, Angeliki Panagiotopoulou, Anatoly A. Soshilov, Guochun He, Michael S. Denison, Prokopios Magiatis
Summary: This study found that Rosmarinus officinalis L. extracts (ROEs) can inhibit the activation of AhR in human body and can also counteract the activation of AhR by ligands and compounds from microbial sources, which may have the potential for the prevention or treatment of skin diseases.
Article
Biochemical Research Methods
Natasha Masub, Evan Austin, Alisen Huang, Jared Jagdeo
Summary: High-fluence LED-RL may decrease fibroblast proliferation by inducing G(0)/G(1) arrest, providing insight into the molecular mechanism underlying LED-RL as an anti-fibrotic therapeutic.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Dermatology
Serena Buscone, Andrei N. Mardaryev, Gillian E. Westgate, Natallia E. Uzunbajakava, Natalia V. Botchkareva
Summary: The study demonstrates that 453 nm blue light induces the accumulation of CRY1 in human keratinocytes and hair follicles. CRY1 plays a role in sustaining human hair growth by affecting the expression of genes related to apoptosis and proliferation.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Immunology
Angela Rico de Souza, Hussein Traboulsi, Xinyu Wang, Jorg H. Fritz, David H. Eidelman, Carolyn J. Baglole
Summary: Research suggests that inhibiting AhR will enhance cigarette smoke-induced pulmonary neutrophilia, but the mechanism of AhR's anti-inflammatory function remains unclear. Through the use of AhR antagonists and genetically modified mice, the study shows that features such as nuclear translocation and binding of response elements are not necessary for AhR to suppress pulmonary neutrophilia.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Hellen Paula Valerio, Felipe Gustavo Ravagnani, Angela Paola Yaya Candela, Bruna Dias Carvalho da Costa, Graziella Eliza Ronsein, Paolo Di Mascio
Summary: This study investigates the subcellular reorganization of the proteome of human keratinocytes in response to UVA light exposure and identifies mitochondria as the main target of UVA-induced stress.
Article
Dermatology
Hugo Moreiras, Clare O'Connor, Mike Bell, Desmond J. Tobin
Summary: The study found that blue and green light can stimulate melanin production in the skin without causing DNA damage or cell apoptosis, unlike UV radiation. This suggests that blue and green light may be a safer way to stimulate melanin synthesis without harmful consequences.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hao Zhang, Hangbo Zhao, Xingyue Zhao, Chenkai Xu, Daniel Franklin, Abraham Vazquez-Guardado, Wubin Bai, Jeffrey Zhao, Kan Li, Giuditta Monti, Wei Lu, Aya Kobeissi, Limei Tian, Xin Ning, Xinge Yu, Sunita Mehta, Debashis Chanda, Yonggang Huang, Shuai Xu, Bethany E. Perez White, John A. Rogers
Summary: Phototherapy using UVA LEDs and light waveguides in a skin-integrated optoelectronic device shows promise in treating challenging dermatological diseases by enhancing light delivery to deep skin and reducing phototoxicity. The device also enables enhanced modulation of gene expression relevant to sclerosing skin diseases and is compatible with design principles in soft, skin-compatible electronics.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Environmental
Sajjad Abbasi, Andrew Turner
Summary: The study quantitatively assessed the exposure of microplastics to adults from different regions of Iran. It found that the highest amount of microplastics were retrieved from head hair, while the lowest were from saliva. Males were exposed to about twice as much microplastics as females. The most abundant type of microplastics found in all body receptors were polyethylene-polyethylene terephthalate and polypropylene fibres of < 100 μm in length.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Polymer Science
Wenhao Li, Jingyu Jia, Xiaochen Sun, Sue Hao, Tengling Ye
Summary: With the development of electronic skin (e-skin), the possibility of creating multifunctional e-skin that surpasses the capabilities of human skin has garnered attention. This study successfully developed a light/pressure bifunctional sensor using CsPbBr3 quantum dots film-based photodetectors and PEDOT: PSS-coated cellulose paper-based pressure sensors. These sensors were integrated into flexible e-skin, allowing for simultaneous detection of light and pressure stimuli. The high photosensitivity and motion monitoring capabilities of these flexible bifunctional sensors demonstrated the feasibility of introducing perovskite photodetectors into e-skins, offering a new direction for the development of flexible multi-functional e-skin.
Review
Chemistry, Analytical
Jiarui Wang, Hannah Lindley-Hatcher, Xuequan Chen, Emma Pickwell-MacPherson
Summary: THz radiation, with its non-ionizing and non-invasive nature, is highly sensitive to water and widely used in biomedical applications. Models describing the interaction between THz and skin are crucial for understanding the optical properties of skin. Various models have been applied to extract hydration profiles and depict structural changes in the skin, showcasing their adaptability, accuracy, and limitations.
Review
Biochemistry & Molecular Biology
Elisabeth Hofmann, Anna Schwarz, Julia Fink, Lars-Peter Kamolz, Petra Kotzbeck
Summary: The skin acts as a protective barrier and controls the transport of water, ions, and nutrients. Animal experiments are commonly used to study skin structure and function, but anatomical and physiological differences between species can limit the translatability of data to humans. In vitro models, such as reconstructed human skin, provide valuable alternatives to animal experiments. This review highlights the progress made in establishing complex in vitro skin models.
Article
Chemistry, Multidisciplinary
Zhenkun Na, Yang Luo, Danica S. Cui, Alexandra Khitun, Stephanie Smelyansky, J. Patrick Loria, Sarah A. Slavoff
Summary: Proteogenomic analysis in humans has uncovered numerous microproteins, with many remaining uncharacterized, lacking secondary structure, and having limited evolutionary conservation. Among them, NBDY, an intrinsically disordered microprotein, has been shown to undergo liquid-liquid phase separation and remixing through phosphorylation, regulating P-body dynamics during cell proliferation. This suggests that microproteins may play a role in liquid-liquid phase separation and remixing behavior to impact cellular processes.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
