Recent Developments in the Synthesis and Reactivity of Isoxazoles: Metal Catalysis and Beyond

Organocatalyzed Asymmetric Vinylogous Michael Reactions of 3,5-Dialkyl-Substituted 4-Nitroisoxazoles: A Direct Method for the Synthesis of Chiral Isoxazole Derivatives

(2015) Yong Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

Isoxazole to oxazole: a mild and unexpected transformation

(2015) Raymond C. F. Jones et al.   CHEMICAL COMMUNICATIONS

Organocatalytic one-pot 1,4-/1,6-/1,2-addition sequence for the stereocontrolled formation of six consecutive stereocenters

(2015) Pankaj Chauhan et al.   CHEMICAL COMMUNICATIONS

“On water” direct catalytic vinylogous Henry (nitroaldol) reactions of isatins for the efficient synthesis of isoxazole substituted 3-hydroxyindolin-2-ones

(2015) Yong Zhang et al.   GREEN CHEMISTRY

Use of 1-pentafluorosulfanyl-phenylacetylenes for the preparation of SF5-substituted five-membered ring heterocycles through 1,3-dipolar cycloadditions. Isoxazoles and isoxazolines

(2015) Simon E. Lopez et al.   JOURNAL OF FLUORINE CHEMISTRY

Stable gold(III) catalysts by oxidative addition of a carbon–carbon bond

(2015) Chung-Yeh Wu et al.   NATURE

An improved procedure to prepare 3-methyl-4-nitroalkylenethylisoxazoles and their reaction under catalytic enantioselective Michael addition with nitromethane

(2015) Maria Moccia et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Two-Step Cyanomethylation Protocol: Convenient Access to Functionalized Aryl- and Heteroarylacetonitriles

(2015) Peter J. Lindsay-Scott et al.   ORGANIC LETTERS

Synthesis and investigation of novel spiro-isoxazolines as anti-cancer agents

(2015) Prasanta Das et al.   TETRAHEDRON LETTERS

Atom-economic generation of gold carbenes: gold-catalyzed formal [3+2] cycloaddition between ynamides and isoxazoles

(2015) Ai-Hua Zhou et al.   Chemical Science

Trienamine-mediated asymmetric [4+2]-cycloaddition of α,β-unsaturated ester surrogates applying 4-nitro-5-styrylisoxazoles

(2014) Yang Li et al.   CHEMICAL COMMUNICATIONS

Asymmetric Synthesis of Agrochemically Attractive Trifluoromethylated Dihydroazoles and Related Compounds under Organocatalysis

(2014) Hiroyuki Kawai et al.   CHEMICAL RECORD

Ruthenium-Catalyzed Cycloadditions of 1-Haloalkynes with Nitrile Oxides and Organic Azides: Synthesis of 4-Haloisoxazoles and 5-Halotriazoles

(2014) James S. Oakdale et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cyclocondensation of Hydroxylamine with 1,3-Bis(het)arylmonothio 1,3-Diketones and 1,3-Bis(het)aryl-3-(methylthio)-2-prop­enones: Synthesis of 3,5-Bis(het)arylisoxazoles with Complementary Regioselectivity

(2014) Byregowda Raghava et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A Model Study toward the Concise Synthesis of Bromotyrosine-Derived Spiroisoxazoline Natural Products and Analogous Core Structures

(2014) Prasanta Das et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

One-Pot Three-Component Synthesis of 3,5-Disubstituted Isoxazoles by a Coupling–Cyclocondensation Sequence

(2014) Hai-Ling Liu et al.   HETEROCYCLES

Electrochemical synthesis of 3,5-disubstituted isoxazoles

(2014) Huan-Lan Xiao et al.   JOURNAL OF ELECTROANALYTICAL CHEMISTRY

Annulated Isoxazoles via [3 + 2] Cycloaddition of Alkenyl Bromides and Oximoyl Chlorides and Ag(I) Promoted Elimination

(2014) Emmanuel B. Castillo-Contreras et al.   JOURNAL OF ORGANIC CHEMISTRY

Preparation of 3,5-Disubstituted Pyrazoles and Isoxazoles from Terminal Alkynes, Aldehydes, Hydrazines, and Hydroxylamine

(2014) Ryo Harigae et al.   JOURNAL OF ORGANIC CHEMISTRY

Direct Synthesis of 4-Fluoroisoxazoles through Gold-Catalyzed Cascade Cyclization–Fluorination of 2-Alkynone O-Methyl Oximes

(2014) Yunkyung Jeong et al.   JOURNAL OF ORGANIC CHEMISTRY

The Role of Aryne Distortions, Steric Effects, and Charges in Regioselectivities of Aryne Reactions

(2014) Jose M. Medina et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NIS-mediated oxidative cyclization of N-(2-trifluoromethyl-3-alkynyl) hydroxylamines: a facile access to 4-trifluoromethyl-5-acylisoxazoles

(2014) Li Zhang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Tandem Synthesis of 3-Halo-5-Substituted Isoxazoles from 1-Copper(I) Alkynes and Dihaloformaldoximes

(2014) Wenwen Chen et al.   ORGANIC LETTERS

Facile Synthesis of Disubstituted Isoxazoles from Homopropargylic Alcohol via C═N Bond Formation

(2014) Pin Gao et al.   ORGANIC LETTERS

Synthesis of Multiply Arylated Heteroarenes, Including Bioactive Derivatives, via Palladium-Catalyzed Direct C–H Arylation of Heteroarenes with (Pseudo)Aryl Halides or Aryliodonium Salts

(2014) Renzo Rossi et al.   SYNTHESIS-STUTTGART

From 4,5,6,7-tetrahydroindoles to 3- or 5-(4,5,6,7-tetrahydroindol-2-yl)isoxazoles in two steps: a regioselective switch between 3- and 5-isomers

(2014) Lyubov N. Sobenina et al.   TETRAHEDRON

Diastereoselective Additive Trifluoromethylation/Halogenation of Isoxazole Triflones: Synthesis of All-Carbon-Functionalized Trifluoromethyl Isoxazoline Triflones

(2014) Hiroyuki Kawai et al.   ChemistryOpen

Enantioselective Addition of Diphenylphosphine to 3-Methyl-4-nitro-5-alkenylisoxazoles

(2013) Renta Jonathan Chew et al.   ADVANCED SYNTHESIS & CATALYSIS

Cyclometallated Gold(III) Complexes as Effective Catalysts for Synthesis of Propargylic Amines, Chiral Allenes and Isoxazoles

(2013) Karen Ka-Yan Kung et al.   ADVANCED SYNTHESIS & CATALYSIS

Organocatalyzed asymmetric vinylogous Michael addition of α,β-unsaturated γ-butyrolactam

(2013) Jinlong Zhang et al.   CHEMICAL COMMUNICATIONS

Transition Metal-Mediated Synthesis of Monocyclic Aromatic Heterocycles

(2013) Anton V. Gulevich et al.   CHEMICAL REVIEWS

A Tandem Strategy for the Synthesis of 1H-Benzo[g]indazoles and Naphtho[2,1-d]isoxazoles fromo-Alkynylarene Chalcones

(2013) Sikkandarkani Akbar et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

One-Pot Three-Component Heteroannulation of β-Oxo Dithioesters, Amines and Hydroxylamine: Regioselective, Facile and Straightforward Entry to 5-Substituted 3-Aminoisoxazoles

(2013) Subhasis Samai et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Regioselective Synthesis of Pyrazoles and Isoxazoles with Cyclopropanated Side-Chain

(2013) Franziska Bendrath et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis and Biological Evaluation of Aryloxazole Derivatives as Antimitotic and Vascular-Disrupting Agents for Cancer Therapy

(2013) Min Jeong Choi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Pharmacological Characterization of N- and O-Substituted 5,6,7,8-Tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol Analogues: Novel 5-HT2A/5-HT2C Receptor Agonists with Pro-Cognitive Properties

(2013) Anders A. Jensen et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Click Chemistry Approach to 5,5′-Disubstituted-3,3′-Bisisoxazoles from Dichloroglyoxime and Alkynes: Luminescent Organometallic Iridium and Rhenium Bisisoxazole Complexes

(2013) Phillip L. van der Peet et al.   JOURNAL OF ORGANIC CHEMISTRY

Regiocomplementary Cycloaddition Reactions of Boryl- and Silylbenzynes with 1,3-Dipoles: Selective Synthesis of Benzo-Fused Azole Derivatives

(2013) Takashi Ikawa et al.   JOURNAL OF ORGANIC CHEMISTRY

Iodine(III)-Mediated [3 + 2] Cyclization for One-Pot Synthesis of Benzo[d]isoxazole-4,7-diols in Aqueous Medium

(2013) Yingwei Hou et al.   JOURNAL OF ORGANIC CHEMISTRY

Iron(III) Chloride/Diorganyl Diselenides: A Tool for Intramolecular Cyclization of Alkynone O-Methyloximes

(2013) Adriane Sperança et al.   JOURNAL OF ORGANIC CHEMISTRY

Capture of an Elusive Nitrile Ylide as an Intermediate in Isoxazole–Oxazole Photoisomerization

(2013) Cláudio M. Nunes et al.   JOURNAL OF ORGANIC CHEMISTRY

Modular Access to Complex Prodiginines: Total Synthesis of (+)-Roseophilin via its 2-Azafulvene Prototropisomer

(2013) James H. Frederich et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pd(II)-Catalyzed C–H Iodination Using Molecular I2 as the Sole Oxidant

(2013) Xiao-Chen Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Drug-Induced Conformational and Dynamical Changes of the S31N Mutant of the Influenza M2 Proton Channel Investigated by Solid-State NMR

(2013) Jonathan K. Williams et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exceptionally fast carbon–carbon bond reductive elimination from gold(III)

(2013) William J. Wolf et al.   Nature Chemistry

Hyrtimomines A–C, New Heteroaromatic Alkaloids from a Sponge Hyrtios sp.

(2013) Rei Momose et al.   ORGANIC LETTERS

Heterocycle–Heterocycle Strategies: (2-Nitrophenyl)isoxazole Precursors to 4-Aminoquinolines, 1H-Indoles, and Quinolin-4(1H)-ones

(2013) Keith C. Coffman et al.   ORGANIC LETTERS

TEMPO-Mediated Aliphatic C–H Oxidation with Oximes and Hydrazones

(2013) Xu Zhu et al.   ORGANIC LETTERS

Highly Efficient and Stereocontrolled Construction of 3,3′-Pyrrolidonyl Spirooxindoles via Organocatalytic Domino Michael/Cyclization Reaction

(2013) Xiong-Li Liu et al.   ORGANIC LETTERS

Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus

(2013) Jun Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional 3-Arylisoxazoles and 3-Aryl-2-isoxazolines from Reaction of Aryl Nitrile Oxides and Enolates: Synthesis and Reactivity

(2013) Paola Vitale et al.   SYNTHESIS-STUTTGART

Advances in the Chemistry of Aminoisoxazole

(2013) Wafaa S. Hamama et al.   SYNTHETIC COMMUNICATIONS

Substituted 2,2′-bipyrroles and pyrrolylfurans via intermediate isoxazolylpyrroles

(2013) James H. Frederich et al.   TETRAHEDRON LETTERS

A concise synthesis of sugar isoxazole conjugates

(2013) Jevgeņija Lugiņina et al.   TETRAHEDRON LETTERS

Palladium-catalyzed benzo[d]isoxazole synthesis by C–H activation/[4 + 1] annulation

(2013) Pingping Duan et al.   Chemical Science

Palladium-catalysed direct heteroarylation of bromobenzenes bearing SO2R substituents at C2 or C4

(2013) Charles Beromeo Bheeter et al.   RSC Advances

Palladium-catalysed regioselective aroylation and acetoxylation of 3,5-diarylisoxazole via ortho C–H functionalisations

(2013) Arghya Banerjee et al.   RSC Advances

Phase transfer catalyzed enantioselective cyclopropanation of 4-nitro-5-styrylisoxazoles

(2012) Claudia Del Fiandra et al.   CHEMICAL COMMUNICATIONS

A Comprehensive History of Arynes in Natural Product Total Synthesis

(2012) Pamela M. Tadross et al.   CHEMICAL REVIEWS

Recent advances in transition-metal-free carbon–carbon and carbon–heteroatom bond-forming reactions using arynes

(2012) Anup Bhunia et al.   CHEMICAL SOCIETY REVIEWS

Acid-Base-Catalysed Condensation Reaction in Water: Isoxazolines and Isoxazoles from Nitroacetates and Dipolarophiles

(2012) Elena Trogu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Solvent-Free Palladium-Catalyzed Direct Arylation of Heteroaromatics with Aryl Bromides

(2012) Souhila Bensaid et al.   ChemSusChem

Intramolecular Iodine-Mediated Oxygen Transfer from Nitro Groups to C≡C Bonds

(2012) Inga Cikotiene   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis and Study of Oxadisilole-Fused Benzisoxazoles or Naphthisoxazoles

(2012) Xuyan Ma et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

One-Pot Synthesis of 3,5-Disubstituted Isoxazoles from Propargylic Alcohols through PropargylicN-Hydroxylamines

(2012) Chada Raji Reddy et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Nitrile Oxide/Alkyne Cycloadditions - A Credible Platform for Synthesis of Bioinspired Molecules by Metal-Free Molecular Clicking

(2012) Frances Heaney   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Isoxazole Triflones

(2012) Hiroyuki Kawai et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Discovery of Highly Potent and Selective α4β2-Nicotinic Acetylcholine Receptor (nAChR) Partial Agonists Containing an Isoxazolylpyridine Ether Scaffold that Demonstrate Antidepressant-like Activity. Part II

(2012) Li-Fang Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Copper-Catalyzed Synthesis of Trisubstituted Isoxazoles via a Cascade Cyclization–Migration Process

(2012) Masafumi Ueda et al.   JOURNAL OF ORGANIC CHEMISTRY

Pd(0)-Catalyzed Decarboxylative Coupling and Tandem C–H Arylation/Decarboxylation for the Synthesis of Heteroaromatic Biaryls

(2012) Debkumar Nandi et al.   JOURNAL OF ORGANIC CHEMISTRY

UV-Laser Photochemistry of Isoxazole Isolated in a Low-Temperature Matrix

(2012) Cláudio M. Nunes et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Trisubstituted Isoxazoles by Palladium(II)-Catalyzed Cascade Cyclization–Alkenylation of 2-Alkyn-1-one O-Methyl Oximes

(2012) Zhigang She et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of isoxazoles en route to semi-aromatized polyketides: dehydrogenation of benzonitrile oxide–para-quinone acetal cycloadducts

(2012) Yoshimitsu Hashimoto et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Highly regioselective nitrile oxide dipolar cycloadditions with ortho-nitrophenyl alkynes

(2012) Melissa L. McIntosh et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

One-step synthesis of differently bis-functionalized isoxazoles by cycloaddition of carbamoylnitrile oxide with β-keto esters

(2012) Nagatoshi Nishiwaki et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Macrocyclic Approach to Tetracycline Natural Products. Investigation of Transannular Alkylations and Michael Additions

(2012) Joseph S. Wzorek et al.   ORGANIC LETTERS

Regioselective Synthesis of 3-Arylamino- and 5-Arylaminoisoxazoles from Enaminones

(2012) Dexuan Xiang et al.   ORGANIC LETTERS

Preparation and Rearrangement of N-Vinyl Nitrones: Synthesis of Spiroisoxazolines and Fluorene-Tethered Isoxazoles

(2012) Dong-Liang Mo et al.   ORGANIC LETTERS

Synthetic Studies Directed toward Dideoxy Lomaiviticinone Lead to Unexpected 1,2-Oxazepine and Isoxazole Formation

(2012) Aleksandra Baranczak et al.   ORGANIC LETTERS

Synthesis of 3,5-Disubstituted Isoxazoles via Cope-Type Hydroamination of 1,3-Dialkynes

(2012) Liangguang Wang et al.   ORGANIC LETTERS

Palladium-Catalysed Direct Arylation of Heteroaromatics Using Unprotected Iodoanilines with Inhibition of the Amination Reaction

(2012) Hamed Ammar et al.   SYNTHESIS-STUTTGART

Copper-Catalyzed Synthesis of N-Heterocyclic Compounds

(2012) Hua Fu et al.   SYNTHESIS-STUTTGART

Improved synthesis of 3-aryl isoxazoles containing fused aromatic rings

(2012) Yousef R. Mirzaei et al.   TETRAHEDRON

Synthesis of ethyl 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylate via regioselective dipolar cycloaddition

(2012) Michael A. Schmidt et al.   TETRAHEDRON LETTERS

N-heterocyclic carbene catalysed homoenolate addition to 3-methyl-4-nitro-5-styrylisoxazoles

(2012) Diana Salazar Illera et al.   TETRAHEDRON LETTERS

Reactivity of the ester group attached isoxazoline, benzisoxazole, and isoxazole: a facial preparation of 3-acyl-substituted these heterocycles

(2012) Kenichi Murai et al.   TETRAHEDRON LETTERS

Catalytic enantioselective carbon-carbon bond formation using cycloisomerization reactions

(2012) Iain D. G. Watson et al.   Chemical Science

Platinum-catalyzed cyclizations viacarbene intermediates: syntheses of complementary positional isomers of isoxazoles

(2012) Paul A. Allegretti et al.   Chemical Science

The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains

(2012) Duncan Hay et al.   MedChemComm

Palladium-Catalyzed Direct Arylation of Heteroaromatics with Activated Aryl Chlorides Using a Sterically Relieved Ferrocenyl-Diphosphane

(2012) David Roy et al.   ACS Catalysis

Isoxazolodihydropyridinones: 1,3-Dipolar Cycloaddition of Nitrile Oxides onto 2,4-Dioxopiperidines

(2012) Keith C. Coffman et al.   ACS Combinatorial Science

Weak Coordination as a Powerful Means for Developing Broadly Useful C–H Functionalization Reactions

(2011) Keary M. Engle et al.   ACCOUNTS OF CHEMICAL RESEARCH

Transition Metal-Free TEMPO-Catalyzed Oxidative Cross- Coupling of Nitrones with Alkynyl-Grignard Reagents

(2011) Sandip Murarka et al.   ADVANCED SYNTHESIS & CATALYSIS

Cascade Formation of Isoxazoles: Facile Base-Mediated Rearrangement of Substituted Oxetanes

(2011) Johannes A. Burkhard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Isoxazole Functionalization Technologies Enable Construction of Tetracycline Derivatives

(2011) Brian Heasley   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Trifluoromethylation of Aromatic Isoxazoles: Regio- and Diastereoselective Route to 5-Trifluoromethyl-2-isoxazolines

(2011) Hiroyuki Kawai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis and Absolute Stereochemistry of Seragakinone A

(2011) Akiomi Takada et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

3,5-Diarylazoles as novel and selective inhibitors of protein kinase D

(2011) Gabriel G. Gamber et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of isoxazoles by hypervalent iodine-induced cycloaddition of nitrile oxides to alkynes

(2011) Anup M. Jawalekar et al.   CHEMICAL COMMUNICATIONS

Transition Metal Catalyzed Cycloisomerizations of 1,n-Allenynes and -Allenenes

(2011) Corinne Aubert et al.   CHEMICAL REVIEWS

Cyclopentyl Methyl Ether: An Alternative Solvent for Palladium-Catalyzed Direct Arylation of Heteroaromatics

(2011) Kassem Beydoun et al.   ChemSusChem

3,5-Dimethylisoxazoles Act As Acetyl-lysine-mimetic Bromodomain Ligands

(2011) David S. Hewings et al.   JOURNAL OF MEDICINAL CHEMISTRY

Iodocyclization of Hydroxylamine Derivatives Based on the Control of Oxidative Aromatization Leading to 2,5-Dihydroisoxazoles and Isoxazoles

(2011) Takashi Okitsu et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic Asymmetric 1,6-Michael Addition of Arylthiols to 3-Methyl-4-nitro-5-alkenyl-isoxazoles with Bifunctional Catalysts

(2011) Qing-Lan Pei et al.   JOURNAL OF ORGANIC CHEMISTRY

Regioselective Synthesis and Slow-Release Suzuki–Miyaura Cross-Coupling of MIDA Boronate-Functionalized Isoxazoles and Triazoles

(2011) Jonathan E. Grob et al.   JOURNAL OF ORGANIC CHEMISTRY

Photochemistry and Vibrational Spectra of Matrix-Isolated Methyl 4-Chloro-5-phenylisoxazole-3-carboxylate

(2011) Susy Lopes et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Palladium-Catalyzed Cyanomethylation of Aryl Halides through Domino Suzuki Coupling–Isoxazole Fragmentation

(2011) Juraj Velcicky et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Pyrolysis of Isoxazole Revisited: A New Primary Product and the Pivotal Role of the Vinylnitrene. A Low-Temperature Matrix Isolation and Computational Study

(2011) Cláudio M. Nunes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic carbene-catalyzed 1,3-dipolar cycloaddition reactions: a facile synthesis of 3,5-di- and 3,4,5-trisubstituted isoxazoles

(2011) Shravankumar Kankala et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Click-chemistry approach to isoxazole-containing α-CF3-substituted α-aminocarboxylates and α-aminophosphonates

(2011) Daria V. Vorobyeva et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Three-Component Coupling Approach to Trachyspic Acid

(2011) Daniel C. Schmitt et al.   ORGANIC LETTERS

Direct Synthesis of Polysubstituted Aluminoisoxazoles and Pyrazoles by a Metalative Cyclization

(2011) Olivier Jackowski et al.   ORGANIC LETTERS

Zinc Triflate Catalyzed Aerobic Cross-Dehydrogenative Coupling (CDC) of Alkynes with Nitrones: A New Entry to Isoxazoles

(2011) Sandip Murarka et al.   ORGANIC LETTERS

Transition-Metal-Catalyzed Uninterrupted Four-Step Sequence to Access Trisubstituted Isoxazoles

(2011) Eric Gayon et al.   ORGANIC LETTERS

Generation of Nitrile Oxides from Oximes Usingt-BuOI and Their Cycloaddition

(2011) Satoshi Minakata et al.   ORGANIC LETTERS

Enantioselective 1,6-Michael addition of anthrone to 3-methyl-4-nitro-5-alkenyl-isoxazoles catalyzed by bifunctional thiourea-tertiary amines

(2011) Hong-Wei Sun et al.   TETRAHEDRON

Methodological advances permit the stereocontrolled construction of diverse fully synthetic tetracyclines containing an all-carbon quaternary center at position C5a

(2011) Peter M. Wright et al.   TETRAHEDRON

Silver-catalyzed synthesis of disubstituted isoxazoles by cyclization of alkynyl oxime ethers

(2011) Masafumi Ueda et al.   TETRAHEDRON

Regioselective conversion of alkynes to 4-substituted and 3,4-disubstituted isoxazoles using titanium-catalyzed multicomponent coupling reactions

(2011) Amila A. Dissanayake et al.   TETRAHEDRON

Studies on the palladium-catalysed direct alkenylation of 1,2-azoles

(2011) Ben Chappell et al.   TETRAHEDRON LETTERS

Studies on the reactivity of 3-methyl-4-nitro-5-styrylisoxazoles with S-nucleophiles

(2011) Simone Bruschi et al.   TETRAHEDRON LETTERS

An efficient one-pot synthesis of 3-aryl-5-methylisoxazoles from aryl aldehydes

(2011) Shirong Zhu et al.   TETRAHEDRON LETTERS

A practical, convergent route to the key precursor to the tetracycline antibiotics

(2011) David A. Kummer et al.   Chemical Science

Palladium-Catalysed Direct Arylation of Heteroaromatics Bearing Unprotected Hydroxyalkyl Functions using Aryl Bromides

(2010) Julien Roger et al.   ADVANCED SYNTHESIS & CATALYSIS

Ynamides: Versatile Tools in Organic Synthesis

(2010) Gwilherm Evano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An improved synthesis of 1,2-benzisoxazoles: TBAF mediated 1,3-dipolar cycloaddition of nitrile oxides and benzyne

(2010) Christian Spiteri et al.   CHEMICAL COMMUNICATIONS

Ynamides: A Modern Functional Group for the New Millennium

(2010) Kyle A. DeKorver et al.   CHEMICAL REVIEWS

Copper-catalyzed azide–alkyne cycloaddition (CuAAC) and beyond: new reactivity of copper(i) acetylides

(2010) Jason E. Hein et al.   CHEMICAL SOCIETY REVIEWS

A General and Convenient Palladium-Catalyzed Carbonylative Sonogashira Coupling of Aryl Bromides

(2010) Xiao-Feng Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Orthogonally Protected Thiazole and Isoxazole Diamino Acids: An Efficient Synthetic Route

(2010) Jeffrey D. Butler et al.   CHEMISTRY-A EUROPEAN JOURNAL

Boronic Acid Catalysis for Mild and Selective [3+2] Dipolar Cycloadditions to Unsaturated Carboxylic Acids

(2010) Hongchao Zheng et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Versatile Iron-Catalyzed Protocol for the One-Pot Synthesis of Isoxazoles or Isoxazolines from the Same Propargylic Alcohols

(2010) Olivier Debleds et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ethyl α-Nitrocinnamates in the Synthesis of Highly Functionalized Isoxazoles

(2010) Kuang-Po Chen et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

4-Isoxazolines: Scaffolds for Organic Synthesis

(2010) Teresa M. V. D. Pinho e Melo   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Carbonates: eco-friendly solvents for palladium-catalysed direct arylation of heteroaromatics

(2010) Jia Jia Dong et al.   GREEN CHEMISTRY

Synthesis, structures, and herbicidal activity of isoxazole derivatives

(2010) Yuhan Zhou et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

A Medicinal Chemist’s Guide to Molecular Interactions

(2010) Caterina Bissantz et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Alkynyliodide Cycloaddition Strategy for the Construction of Iodoisoxazoles

(2010) James A. Crossley et al.   JOURNAL OF ORGANIC CHEMISTRY

Unexpected Heterocyclization of Electrophilic Alkenes by Tetranitromethane in the Presence of Triethylamine. Synthesis of 3-Nitroisoxazoles

(2010) Yulia A. Volkova et al.   JOURNAL OF ORGANIC CHEMISTRY

Efficient and Regioselective Synthesis of 5-Hydroxy-2-isoxazolines: Versatile Synthons for Isoxazoles, β-Lactams, and γ-Amino Alcohols

(2010) Shibing Tang et al.   JOURNAL OF ORGANIC CHEMISTRY

Carboxylation of C−H Bonds UsingN-Heterocyclic Carbene Gold(I) Complexes

(2010) Ine I. F. Boogaerts et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal-Free Sequential [3 + 2]-Dipolar Cycloadditions using Cyclooctynes and 1,3-Dipoles of Different Reactivity

(2010) Brian C. Sanders et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne

(2010) Christian Spiteri et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of Benzisoxazoles by the [3 + 2] Cycloaddition ofin situGenerated Nitrile Oxides and Arynes

(2010) Anton V. Dubrovskiy et al.   ORGANIC LETTERS

Direct Synthesis of Trisubstituted Isoxazoles through Gold-Catalyzed Domino Reaction of Alkynyl Oxime Ethers

(2010) Masafumi Ueda et al.   ORGANIC LETTERS

Unexpected Regioselectivity in Cycloisomerization of 2-Alkynyl-3-nitro­thiophenes

(2010) Inga Cikotiene et al.   SYNLETT

Cycloaddition of benzynes and nitrile oxides: synthesis of benzisoxazoles

(2010) James A. Crossley et al.   TETRAHEDRON LETTERS

Preparation of mono-labelled aliphatic polyacids via isoxazole derivatives

(2010) Mauro F.A. Adamo et al.   TETRAHEDRON LETTERS

Catalytic Asymmetric Conjugate Addition of Nitroalkanes to 4-Nitro-5-styrylisoxazoles

(2009) Andrea Baschieri et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed C3 or C4 Direct Arylation of Heteroaromatic Compounds with Aryl Halides by CH Bond Activation

(2009) Julien Roger et al.   ChemCatChem

Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation

(2009) Ishwar Singh et al.   CHEMICAL COMMUNICATIONS

Base- and Copper-Catalysed Condensation of Primary Activated Nitro Compounds with Enolisable Compounds

(2009) Elena Trogu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Ligand-Free-Palladium-Catalyzed Direct 4-Arylation of Isoxazoles Using Aryl Bromides

(2009) Yacoub Fall et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Water Mediated Construction of Trisubstituted Pyrazoles/Isoxazoles Library Using Ketene Dithioacetals

(2009) Mahesh M. Savant et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

3,4-Diaryl-isoxazoles and -imidazoles as Potent Dual Inhibitors of p38α Mitogen Activated Protein Kinase and Casein Kinase 1δ†

(2009) Christian Peifer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficient Chemoenzymatic Dynamic Kinetic Resolution of 1-Heteroaryl Ethanols

(2009) Karl S. A. Vallin et al.   JOURNAL OF ORGANIC CHEMISTRY

Theoretical Investigations of the Photochemical Isomerizations of Indoxazene and Isoxazole

(2009) Ming-Der Su   JOURNAL OF ORGANIC CHEMISTRY

3,5-Isoxazoles from α-bromo-pentafluorophenyl vinylsulfonates: Synthesis of sulfonates and sulfonamides

(2009) Chieh Chien Lee et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of 3-Aminoisoxazoles via the Addition−Elimination of Amines on 3-Bromoisoxazolines

(2009) Mélina Girardin et al.   ORGANIC LETTERS

Simple Conversion of Enamines to 2H-Azirines and Their Rearrangements under Thermal Conditions

(2009) Xiaoxun Li et al.   ORGANIC LETTERS

Efficient and Regioselective One-Pot Synthesis of 3-Substituted and 3,5-Disubstituted Isoxazoles

(2009) Shibing Tang et al.   ORGANIC LETTERS

A highly regioselective tandem 1,3-dipolar cycloaddition of cyclopropene 1,1-diesters and nitrile oxides: synthesis of highly functionalized isoxazoles

(2009) Shaojin Chen et al.   TETRAHEDRON

Reaction of 5-(1-bromo-2-aryl-vinyl)-3-methyl-4-nitro-isoxazoles and 1,3-dicarbonyl compounds

(2009) Mauro F.A. Adamo et al.   TETRAHEDRON

Recent advances in the synthesis of (hetero)aryl-substituted heteroarenes via transition metal-catalysed direct (hetero)arylation of heteroarene C–H bonds with aryl halides or pseudohalides, diaryliodonium salts, and potassium aryltrifluoroborates

(2009) Fabio Bellina et al.   TETRAHEDRON

Isoxazole-Assisted Direct Substitution of the Hydroxy Group in α-Ketols: Introduction of Angular Substituents in a Polycyclic System

(2008) Hiroshi Takikawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium-Catalyzed Cycloaddition of Nitrile Oxides and Alkynes: Practical Synthesis of Isoxazoles

(2008) Scott Grecian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Formation of α-Hydroxy-β-diketones through Hydroxylation of Isoxazolium Salts: Stereoselective Approach to Angularcis-Diols in Polycyclic Systems

(2008) Hiroshi Takikawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cycloisomerization of 1,n-Enynes: Challenging Metal-Catalyzed Rearrangements and Mechanistic Insights

(2008) Véronique Michelet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Coinage Metal-Assisted Synthesis of Heterocycles

(2008) Nitin T. Patil et al.   CHEMICAL REVIEWS

Cu-Catalyzed Azide−Alkyne Cycloaddition

(2008) Morten Meldal et al.   CHEMICAL REVIEWS

Solution Phase Synthesis of a Diverse Library of Highly Substituted Isoxazoles

(2008) Jesse P. Waldo et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Novel Terphenyls and 3,5-Diaryl Isoxazole Derivatives Endowed with Growth Supporting and Antiapoptotic Properties

(2008) Daniele Simoni et al.   JOURNAL OF MEDICINAL CHEMISTRY

5-tert-Butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide Derivatives as Novel Potent Inhibitors ofMycobacterium tuberculosisPantothenate Synthetase: Initiating a Quest for New Antitubercular Drugs

(2008) Subash Velaparthi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Experimental and DFT Studies on Competitive Heterocyclic Rearrangements. 3.†A Cascade Isoxazole−1,2,4-Oxadiazole−Oxazole Rearrangement‡

(2008) Andrea Pace et al.   JOURNAL OF ORGANIC CHEMISTRY

One-Pot Synthesis of Highly Functionalized Pyridines via a Rhodium Carbenoid Induced Ring Expansion of Isoxazoles

(2008) James R. Manning et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Robust Platform for the Synthesis of New Tetracycline Antibiotics

(2008) Cuixiang Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The advent and development of organocatalysis

(2008) David W. C. MacMillan   NATURE

Efficient and Divergent Synthesis of Fully Substituted 1H-Pyrazoles and Isoxazoles from Cyclopropyl Oximes

(2008) Kewei Wang et al.   ORGANIC LETTERS

Synthesis of Homochiral Dihydroxy-4-nitroisoxazolines via One-Pot Asymmetric Dihydroxylation−Reduction

(2008) Mauro F. A. Adamo et al.   ORGANIC LETTERS

Palladium-Catalyzed Arylation and Alkylation of 3,5-Diphenylisoxazole with Boronic Acids via C−H Activation

(2008) Jean-Ho Chu et al.   ORGANOMETALLICS

N,N-Disubstituted propargylamines as tools in the sequential 1,3-dipolar cycloaddition/arylation processes to the formation of polyheterocyclic systems

(2008) Luca Basolo et al.   TETRAHEDRON

Efficient route to 2H-1,3-oxazines through ring expansion of isoxazoles by rhodium carbenoids

(2008) James R. Manning et al.   TETRAHEDRON

Vinylogous nitroaldol (Henry) reaction using 3,5-diethyl-4-nitroisoxazole and carbonyl compounds

(2008) Mauro F.A. Adamo et al.   TETRAHEDRON

Aziridination of 3-methyl-4-nitro-5-styrylisoxazoles

(2008) Mauro F.A. Adamo et al.   TETRAHEDRON LETTERS

Oxonium ion-mediated synthesis of 4-substituted spiro-isoxazolines

(2008) Eric McClendon et al.   TETRAHEDRON LETTERS

Practical route for N,O-heteroatom interchange in 3,5-disubstituted-4-nitroisoxazoles

(2007) Mauro F.A. Adamo et al.   TETRAHEDRON LETTERS