One-Pot Three-Component Heteroannulation of β-Oxo Dithioesters, Amines and Hydroxylamine: Regioselective, Facile and Straightforward Entry to 5-Substituted 3-Aminoisoxazoles

Acid-Base-Catalysed Condensation Reaction in Water: Isoxazolines and Isoxazoles from Nitroacetates and Dipolarophiles

(2012) Elena Trogu et al.   CHEMISTRY-A EUROPEAN JOURNAL

One-Pot Synthesis of 3,5-Disubstituted Isoxazoles from Propargylic Alcohols through PropargylicN-Hydroxylamines

(2012) Chada Raji Reddy et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Trisubstituted Isoxazoles by Palladium(II)-Catalyzed Cascade Cyclization–Alkenylation of 2-Alkyn-1-one O-Methyl Oximes

(2012) Zhigang She et al.   JOURNAL OF ORGANIC CHEMISTRY

One-step synthesis of differently bis-functionalized isoxazoles by cycloaddition of carbamoylnitrile oxide with β-keto esters

(2012) Nagatoshi Nishiwaki et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Tandem reaction of propargyl alcohols and N-tosyl hydroxylamine: switchable synthesis of 2,5-dihydroisoxazoles and 4-halo-2,5-dihydroisoxazoles

(2012) Yuanxun Zhu et al.   TETRAHEDRON

4-Dimethylamino Pyridine-Promoted One-Pot Three-Component Regioselective Synthesis of Highly Functionalized 4H-Thiopyrans via Heteroannulation of β-Oxodithioesters

(2012) Rajiv Kumar Verma et al.   ACS Combinatorial Science

Construction of five- and six-membered heterocycles on both Cp rings of the ferrocene moiety of α-oxoketene-S,S-acetal and β-oxodithioester via heteroaromatic annulation

(2012) Girijesh Kumar Verma et al.   RSC Advances

Isoxazole substituted chromans against oxidative stress-induced neuronal damage

(2011) Maria Koufaki et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of isoxazoles by hypervalent iodine-induced cycloaddition of nitrile oxides to alkynes

(2011) Anup M. Jawalekar et al.   CHEMICAL COMMUNICATIONS

Highly Regioselective One-Pot, Three-Component Synthesis of 1-Aryl-3,4-Substituted/Annulated-5-(Cycloamino)/(Alkylamino)pyrazoles from β-Oxodithioesters

(2011) Ganesh C. Nandi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Discovery, Synthesis, and Biological Evaluation of a Novel Group of Selective Inhibitors of Filoviral Entry

(2011) Maria V. Yermolina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Hydrochloride (CEP-32496), a Highly Potent and Orally Efficacious Inhibitor of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) V600E

(2011) Martin W. Rowbottom et al.   JOURNAL OF MEDICINAL CHEMISTRY

One-Pot Two-Component [3 + 2] Cycloaddition/Annulation Protocol for the Synthesis of Highly Functionalized Thiophene Derivatives

(2011) Ganesh Chandra Nandi et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of functionalized 2,3-dihydroisoxazoles by domino reactions in water and unexpected ring-opening reactions of 2,3-dihydroisoxazoles

(2011) Ping Li et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Direct Synthesis of Polysubstituted Aluminoisoxazoles and Pyrazoles by a Metalative Cyclization

(2011) Olivier Jackowski et al.   ORGANIC LETTERS

Transition-Metal-Catalyzed Uninterrupted Four-Step Sequence to Access Trisubstituted Isoxazoles

(2011) Eric Gayon et al.   ORGANIC LETTERS

Regioselective Synthesis of Tetrahydrothiochromen-5-ones via a One-Pot Three-Component Solvent-Free Domino Protocol

(2011) Sushobhan Chowdhury et al.   ORGANIC LETTERS

Silver-catalyzed synthesis of disubstituted isoxazoles by cyclization of alkynyl oxime ethers

(2011) Masafumi Ueda et al.   TETRAHEDRON

Boronic Acids and Esters in the Petasis-Borono Mannich Multicomponent Reaction

(2010) Nuno R. Candeias et al.   CHEMICAL REVIEWS

Novel 3-alkanoyl/aroyl/heteroaroyl-2H-chromene-2-thiones: Synthesis and evaluation of their antioxidant activities

(2010) Okram Mukherjee Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tandem Ugi MCR/Mitsunobu Cyclization as a Short, Protecting-Group-Free Route to Benzoxazinones with Four Diversity Points

(2010) Luca Banfi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

New multicomponent domino reactions (MDRs) in water: highly chemo-, regio- and stereoselective synthesis of spiro{[1,3]dioxanopyridine}-4,6-diones and pyrazolo[3,4-b]pyridines

(2010) Ning Ma et al.   GREEN CHEMISTRY

Biginelli and Hantzsch-Type Reactions Leading to Highly Functionalized Dihydropyrimidinone, Thiocoumarin, and Pyridopyrimidinone Frameworks via Ring Annulation with β-Oxodithioesters

(2010) Ganesh Chandra Nandi et al.   JOURNAL OF ORGANIC CHEMISTRY

Brønsted Base-Catalyzed One-Pot Three-Component Biginelli-Type Reaction: An Efficient Synthesis of 4,5,6-Triaryl-3,4-dihydropyrimidin-2(1H)-one and Mechanistic Study

(2010) Zhi-Liang Shen et al.   JOURNAL OF ORGANIC CHEMISTRY

An Alkynyliodide Cycloaddition Strategy for the Construction of Iodoisoxazoles

(2010) James A. Crossley et al.   JOURNAL OF ORGANIC CHEMISTRY

Efficient and Regioselective Synthesis of 5-Hydroxy-2-isoxazolines: Versatile Synthons for Isoxazoles, β-Lactams, and γ-Amino Alcohols

(2010) Shibing Tang et al.   JOURNAL OF ORGANIC CHEMISTRY

Rapid Cu-Free Click Chemistry with Readily Synthesized Biarylazacyclooctynones

(2010) John C. Jewett et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An expedient route to highly functionalized 2H-chromene-2-thiones via ring annulation of β-oxodithioesters catalyzed by InCl3 under solvent-free conditions

(2010) Rajiv Kumar Verma et al.   TETRAHEDRON

Design and synthesis of 3,5-diarylisoxazole derivatives as novel class of anti-hyperglycemic and lipid lowering agents

(2009) Atul Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of 5-isoxazol-5-yl-2′-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses

(2009) Yoon-Suk Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and evaluation of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-aminopropanamide as human cannabinoid-1 receptor (CB1R) inverse agonists

(2009) Wu Du et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Michael Additions versus Cycloaddition Condensations with Ethyl Nitroacetate and Electron-Deficient Olefins

(2009) Elena Trogu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Base- and Copper-Catalysed Condensation of Primary Activated Nitro Compounds with Enolisable Compounds

(2009) Elena Trogu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

3,5-Disubstituted Isoxazolines as Potential Molecular Kits for Liquid-Crystalline Materials

(2009) Aline Tavares et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Efficient Synthesis of Trisubstituted Pyrazoles and Isoxazoles Using a Traceless “Catch and Release” Solid-Phase Strategy

(2009) Wenli Ma et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Cyanoacetamide MCR (III): Three-Component Gewald Reactions Revisited

(2009) Kan Wang et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Water Mediated Construction of Trisubstituted Pyrazoles/Isoxazoles Library Using Ketene Dithioacetals

(2009) Mahesh M. Savant et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Identification ofN-(5-tert-Butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Dihydrochloride (AC220), a Uniquely Potent, Selective, and Efficacious FMS-Like Tyrosine Kinase-3 (FLT3) Inhibitor

(2009) Qi Chao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phosphinic Tripeptides as Dual Angiotensin-Converting Enzyme C-Domain and Endothelin-Converting Enzyme-1 Inhibitors

(2009) Nicolas Jullien et al.   JOURNAL OF MEDICINAL CHEMISTRY

Catalytic Asymmetric Passerini-Type Reaction: Chiral Aluminum−Organophosphate-Catalyzed Enantioselective α-Addition of Isocyanides to Aldehydes

(2009) Tao Yue et al.   JOURNAL OF ORGANIC CHEMISTRY

Application of β-Oxodithioesters in Domino and Multicomponent Reactions: Facile Route to Dihydropyrimidines and Coumarins

(2009) Okram Mukherjee Singh et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 3-Aminoisoxazoles via the Addition−Elimination of Amines on 3-Bromoisoxazolines

(2009) Mélina Girardin et al.   ORGANIC LETTERS

Approach to Tetrodotoxin via the Oxidative Amidation of a Phenol

(2009) Brian A. Mendelsohn et al.   ORGANIC LETTERS

Efficient and Regioselective One-Pot Synthesis of 3-Substituted and 3,5-Disubstituted Isoxazoles

(2009) Shibing Tang et al.   ORGANIC LETTERS

Novel Terphenyls and 3,5-Diaryl Isoxazole Derivatives Endowed with Growth Supporting and Antiapoptotic Properties

(2008) Daniele Simoni et al.   JOURNAL OF MEDICINAL CHEMISTRY

One-Pot Synthesis of Highly Functionalized Pyridines via a Rhodium Carbenoid Induced Ring Expansion of Isoxazoles

(2008) James R. Manning et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Pluraflavin A “Aglycone”

(2008) Benjamin J. D. Wright et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient and Divergent Synthesis of Fully Substituted 1H-Pyrazoles and Isoxazoles from Cyclopropyl Oximes

(2008) Kewei Wang et al.   ORGANIC LETTERS