Withania somnifera and Its Withanolides Attenuate Oxidative and Inflammatory Responses and Up-Regulate Antioxidant Responses in BV-2 Microglial Cells

A Novel Allosteric Mechanism of NF-κB Dimerization and DNA Binding Targeted by an Anti-Inflammatory Drug

(2016) Shaked Ashkenazi et al.   MOLECULAR AND CELLULAR BIOLOGY

Nootropic potential of Ashwagandha leaves: Beyond traditional root extracts

(2016) Renu Wadhwa et al.   NEUROCHEMISTRY INTERNATIONAL

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

(2015) Joanna D. Wardyn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Ashwagandha attenuates TNF-α- and LPS-induced NF-κB activation and CCL2 and CCL5 gene expression in NRK-52E cells

(2015) Elizabeth Grunz-Borgmann et al.   BMC Complementary and Alternative Medicine

Pharmacologic overview of Withania somnifera, the Indian Ginseng

(2015) Nawab John Dar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Identification and quantitative analysis of cellular proteins affected by treatment with withaferin a using a SILAC-based proteomics approach

(2015) Malathi Narayan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Microglia and neuroprotection

(2015) Zhihong Chen et al.   JOURNAL OF NEUROCHEMISTRY

Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway

(2015) Dennis Y. Chuang et al.   Journal of Neuroinflammation

Withania somnifera(Ashwagandha) in neurobehavioural disorders induced by brain oxidative stress in rodents: a systematic review and meta-analysis

(2015) Sharanbasappa Durg et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Inhibition of microglial activation by elderberry extracts and its phenolic components

(2015) Agnes Simonyi et al.   LIFE SCIENCES

Microglial HO-1 induction by curcumin provides antioxidant, antineuroinflammatory, and glioprotective effects

(2015) Esther Parada et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells: Role of MAPKs on the Nrf2 Pathway and Induction of Heme Oxygenase-1

(2015) Grace Y. Sun et al.   PLoS One

Combinations of Ashwagandha Leaf Extracts Protect Brain-Derived Cells against Oxidative Stress and Induce Differentiation

(2015) Navjot Shah et al.   PLoS One

Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases

(2014) Li Gan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Effects of Ashwagandha (Roots of Withania somnifera) on Neurodegenerative Diseases

(2014) Tomoharu Kuboyama et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Carbon monoxide and the CNS: challenges and achievements

(2014) Cláudia S F Queiroga et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sublime Microglia: Expanding Roles for the Guardians of the CNS

(2014) Michael W. Salter et al.   CELL

The Transcription Factor Nrf2 Is a Therapeutic Target against Brain Inflammation

(2014) N. G. Innamorato et al.   JOURNAL OF IMMUNOLOGY

Sutherlandia frutescens Ethanol Extracts Inhibit Oxidative Stress and Inflammatory Responses in Neurons and Microglial Cells

(2014) Jinghua Jiang et al.   PLoS One

Molecular Targets and Mechanisms of Cancer Prevention and Treatment by Withaferin A, A Naturally Occurring Steroidal Lactone

(2013) Avani R. Vyas et al.   AAPS Journal

Quercetin inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-κB pathway and activating the Nrf2-dependent HO-1 pathway

(2013) Chang-Hee Kang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells

(2013) Dennis Y Chuang et al.   Journal of Neuroinflammation

Determination of withaferin A and withanolide A in mice plasma using high-performance liquid chromatography-tandem mass spectrometry: Application to pharmacokinetics after oral administration of Withania somnifera aqueous extract

(2013) Dada Patil et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

NRF2-regulation in brain health and disease: Implication of cerebral inflammation

(2013) Mats Sandberg et al.   NEUROPHARMACOLOGY

A kavalactone derivative inhibits lipopolysaccharide-stimulated iNOS induction and NO production through activation of Nrf2 signaling in BV2 microglial cells

(2013) Riyako Terazawa et al.   PHARMACOLOGICAL RESEARCH

Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells

(2013) Roberta Foresti et al.   PHARMACOLOGICAL RESEARCH

Ashwagandha (Withania somnifera) Reverses β-Amyloid1-42 Induced Toxicity in Human Neuronal Cells: Implications in HIV-Associated Neurocognitive Disorders (HAND)

(2013) Kesava Rao Venkata Kurapati et al.   PLoS One

Molecular insight in the multifunctional activities of Withaferin A

(2012) Wim Vanden Berghe et al.   BIOCHEMICAL PHARMACOLOGY

Targeting Heme Oxygenase-1 for Neuroprotection and Neuroinflammation in Neurodegenerative Diseases

(2012) Agnieszka Jazwa et al.   CURRENT DRUG TARGETS

Withaferin A Alters Intermediate Filament Organization, Cell Shape and Behavior

(2012) Boris Grin et al.   PLoS One

Withaferin A down-regulates lipopolysaccharide-induced cyclooxygenase-2 expression and PGE2 production through the inhibition of STAT1/3 activation in microglial cells

(2011) Kyoung-jin Min et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA2-IIA expression in astrocytes and microglia

(2011) Wenwen Sheng et al.   Journal of Neuroinflammation

Modulation of Nrf2/ARE Pathway by Food Polyphenols: A Nutritional Neuroprotective Strategy for Cognitive and Neurodegenerative Disorders

(2011) Giovanni Scapagnini et al.   MOLECULAR NEUROBIOLOGY

Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders

(2010) Vittorio Calabrese et al.   ANTIOXIDANTS & REDOX SIGNALING

Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential

(2010) Ananta Paine et al.   BIOCHEMICAL PHARMACOLOGY

Immunoregulatory effects of HO-1: how does it work?

(2009) Miguel P Soares et al.   CURRENT OPINION IN PHARMACOLOGY

Sulforaphane suppresses LPS-induced inflammation in primary rat microglia

(2009) Lars-Ove Brandenburg et al.   INFLAMMATION RESEARCH

Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine

(2009) Mohammad Mirjalili et al.   MOLECULES

Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis

(2008) S Nair et al.   BRITISH JOURNAL OF CANCER

Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders

(2008) P J Syapin   BRITISH JOURNAL OF PHARMACOLOGY

Withaferin A inhibits iNOS expression and nitric oxide production by Akt inactivation and down-regulating LPS-induced activity of NF-κB in RAW 264.7 cells

(2008) Jung Hwa Oh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Botanical Phenolics and Brain Health

(2008) Albert Y. Sun et al.   NEUROMOLECULAR MEDICINE

Withania somnifera: An Indian ginseng

(2007) S.K. Kulkarni et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY