Metabolomics in rheumatic diseases: desperately seeking biomarkers

PI3K inhibitors in inflammation, autoimmunity and cancer

(2015) Anne-Katrien Stark et al.   CURRENT OPINION IN PHARMACOLOGY

Lipid Metabolism, Apoptosis and Cancer Therapy

(2015) Chunfa Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metabolic analysis of knee synovial fluid as a potential diagnostic approach for osteoarthritis

(2015) Beata Mickiewicz et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Relationship Between Blood Plasma and Synovial Fluid Metabolite Concentrations in Patients with Osteoarthritis

(2015) W. Zhang et al.   JOURNAL OF RHEUMATOLOGY

Optimized Analytical Procedures for the Untargeted Metabolomic Profiling of Human Urine and Plasma by Combining Hydrophilic Interaction (HILIC) and Reverse-Phase Liquid Chromatography (RPLC)–Mass Spectrometry

(2015) Kévin Contrepois et al.   MOLECULAR & CELLULAR PROTEOMICS

Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K

(2015) Rupert Courtnay et al.   MOLECULAR BIOLOGY REPORTS

Fatty acid metabolism in the regulation of T cell function

(2015) Matthias Lochner et al.   TRENDS IN IMMUNOLOGY

Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions

(2015) Clovis S. Palmer et al.   Frontiers in Immunology

Metabolomics analysis of collagen-induced arthritis in rats and interventional effects of oral tolerance

(2014) Xinghong Ding et al.   ANALYTICAL BIOCHEMISTRY

Evaluation of Fast 2D NMR for Metabolomics

(2014) Adrien Le Guennec et al.   ANALYTICAL CHEMISTRY

Choline kinase inhibition in rheumatoid arthritis

(2014) M Guma et al.   ANNALS OF THE RHEUMATIC DISEASES

Recent advances in the reconstruction of metabolic models and integration of omics data

(2014) Rajib Saha et al.   CURRENT OPINION IN BIOTECHNOLOGY

Metabolism of activated T lymphocytes

(2014) Jason A Maciolek et al.   CURRENT OPINION IN IMMUNOLOGY

Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients

(2014) Georgia McDonald et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice

(2014) Fei Xiao et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Metabolism of stromal and immune cells in health and disease

(2014) Bart Ghesquière et al.   NATURE

Constraint-based models predict metabolic and associated cellular functions

(2014) Aarash Bordbar et al.   NATURE REVIEWS GENETICS

Persisting eicosanoid pathways in rheumatic diseases

(2014) Marina Korotkova et al.   Nature Reviews Rheumatology

Rapid Resolution Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry-Based Metabolomics Approach to Study the Effects of Jieduquyuziyin Prescription on Systemic Lupus Erythematosus

(2014) Xinghong Ding et al.   PLoS One

Global Metabolite Profiling of Synovial Fluid for the Specific Diagnosis of Rheumatoid Arthritis from Other Inflammatory Arthritis

(2014) Sooah Kim et al.   PLoS One

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Classification of osteoarthritis phenotypes by metabolomics analysis

(2014) Weidong Zhang et al.   BMJ Open

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Metabolic Profiling Predicts Response to Anti-Tumor Necrosis Factor α Therapy in Patients With Rheumatoid Arthritis

(2013) Sabrina R. Kapoor et al.   ARTHRITIS AND RHEUMATISM

The Impact of Inflammation on Metabolomic Profiles in Patients With Arthritis

(2013) Stephen P. Young et al.   ARTHRITIS AND RHEUMATISM

A Lipidomic Study of Phospholipid Classes and Species in Human Synovial Fluid

(2013) Marta Krystyna Kosinska et al.   ARTHRITIS AND RHEUMATISM

Metabolomics in rheumatic diseases: The potential of an emerging methodology for improved patient diagnosis, prognosis, and treatment efficacy

(2013) Roberta Priori et al.   AUTOIMMUNITY REVIEWS

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

Immune-suppressive properties of the tumor microenvironment

(2013) Jürgen C. Becker et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Influence of Metabolism on Epigenetics and Disease

(2013) William G. Kaelin et al.   CELL

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

New Advances in Separation Science for Metabolomics: Resolving Chemical Diversity in a Post-Genomic Era

(2013) Naomi L. Kuehnbaum et al.   CHEMICAL REVIEWS

Pharmacometabolomics: Implications for Clinical Pharmacology and Systems Pharmacology

(2013) R Kaddurah-Daouk et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Sphingosine 1-phosphate receptor agonists: a patent review (2010 – 2012)

(2013) Edward Roberts et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Current immunotherapy in rheumatoid arthritis

(2013) Florian MP Meier et al.   Immunotherapy

Lactate Engages Receptor Tyrosine Kinases Axl, Tie2, and Vascular Endothelial Growth Factor Receptor 2 to Activate Phosphoinositide 3-Kinase/Akt and Promote Angiogenesis

(2013) Guo-Xiang Ruan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liquid chromatography–mass spectrometry in metabolomics research: Mass analyzers in ultra high pressure liquid chromatography coupling

(2013) Sara Forcisi et al.   JOURNAL OF CHROMATOGRAPHY A

Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

(2013) Zhen Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Serum Metabolic Signatures of Four Types of Human Arthritis

(2013) Miao Jiang et al.   JOURNAL OF PROTEOME RESEARCH

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose

(2013) Tiago B Rodrigues et al.   NATURE MEDICINE

Metabolic targets for cancer therapy

(2013) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

The Human Urine Metabolome

(2013) Souhaila Bouatra et al.   PLoS One

Metabolomics of the Tumor Microenvironment in Pediatric Acute Lymphoblastic Leukemia

(2013) Stefano Tiziani et al.   PLoS One

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

Metabolism in physiological cell proliferation and differentiation

(2013) Michalis Agathocleous et al.   TRENDS IN CELL BIOLOGY

Succinate: a metabolic signal in inflammation

(2013) Evanna Mills et al.   TRENDS IN CELL BIOLOGY

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

Stable Isotope-Assisted Metabolomics for Network-Wide Metabolic Pathway Elucidation

(2012) Darren J. Creek et al.   ANALYTICAL CHEMISTRY

Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC–MS/MS

(2012) Martin Giera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas

(2012) F Seguin et al.   BRITISH JOURNAL OF CANCER

Gut Microbiota Composition and Activity in Relation to Host Metabolic Phenotype and Disease Risk

(2012) Elaine Holmes et al.   Cell Metabolism

Breathless cancer cells get fat on glutamine

(2012) Dimitrios Anastasiou et al.   CELL RESEARCH

Stable isotope-assisted metabolomics to detect metabolic flux changes in mammalian cell cultures

(2012) Daniel Mueller et al.   CURRENT OPINION IN BIOTECHNOLOGY

Metabolomics platforms for genome wide association studies—linking the genome to the metabolome

(2012) Jerzy Adamski et al.   CURRENT OPINION IN BIOTECHNOLOGY

The gut microbiota elicits a profound metabolic reorientation in the mouse jejunal mucosa during conventionalisation

(2012) Sahar El Aidy et al.   GUT

Metabolic reprogramming and metabolic dependency in T cells

(2012) Ruoning Wang et al.   IMMUNOLOGICAL REVIEWS

3-bromopyruvate (3BP) a fast acting, promising, powerful, specific, and effective “small molecule” anti-cancer agent taken from labside to bedside: introduction to a special issue

(2012) Peter L. Pedersen   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug

(2012) Simone Cardaci et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Recent developments in liquid chromatography–mass spectrometry and related techniques

(2012) Michal Holčapek et al.   JOURNAL OF CHROMATOGRAPHY A

Liquid chromatography–nuclear magnetic resonance coupling as alternative to liquid chromatography–mass spectrometry hyphenations: Curious option or powerful and complementary routine tool?

(2012) Sonja Sturm et al.   JOURNAL OF CHROMATOGRAPHY A

Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis

(2012) Ioanna Nikitopoulou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism

(2012) Sonja C. Schriever et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

(2012) Y. Liu et al.   MOLECULAR CANCER THERAPEUTICS

How cancer metabolism is tuned for proliferation and vulnerable to disruption

(2012) Almut Schulze et al.   NATURE

Metabolomics: the apogee of the omics trilogy

(2012) Gary J. Patti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pathogenic role of autotaxin and LPA

(2012) Emma Leah   Nature Reviews Rheumatology

Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors

(2012) Nunzio Bottini et al.   Nature Reviews Rheumatology

HMDB 3.0—The Human Metabolome Database in 2013

(2012) David S. Wishart et al.   NUCLEIC ACIDS RESEARCH

Metabolic Disturbances Associated with Systemic Lupus Erythematosus

(2012) Tianfu Wu et al.   PLoS One

Characterization of Rheumatoid Arthritis Subtypes Using Symptom Profiles, Clinical Chemistry and Metabolomics Measurements

(2012) Herman A. van Wietmarschen et al.   PLoS One

Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis

(2012) DeAnna A. Baker et al.   RHEUMATOLOGY INTERNATIONAL

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

Genome-wide association studies with metabolomics

(2012) Jerzy Adamski   Genome Medicine

Highly Sensitive GC/MS/MS Method for Quantitation of Amino and Nonamino Organic Acids

(2011) Hans F. N. Kvitvang et al.   ANALYTICAL CHEMISTRY

High sensitivity quantitative lipidomics analysis of fatty acids in biological samples by gas chromatography–mass spectrometry

(2011) Oswald Quehenberger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Elucidation of Cellular Metabolism Via Metabolomics and Stable-Isotope Assisted Metabolomics

(2011) Karsten Hiller et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

A high-resolution NMR probe in which the coil and preamplifier are cooled with liquid helium

(2011) P. Styles et al.   JOURNAL OF MAGNETIC RESONANCE

Therapeutic targeting of cancer cell metabolism

(2011) Chi V. Dang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

1H NMR-based metabolomic study of metabolic profiling for systemic lupus erythematosus

(2011) X Ouyang et al.   LUPUS

Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses

(2011) Xianlin Han et al.   MASS SPECTROMETRY REVIEWS

Discovery of Candidate Serum Proteomic and Metabolomic Biomarkers in Ankylosing Spondylitis

(2011) Roman Fischer et al.   MOLECULAR & CELLULAR PROTEOMICS

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

The Human Plasma Lipidome

(2011) Oswald Quehenberger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Global metabolic profiling of human osteoarthritic synovium

(2011) S.B. Adams et al.   OSTEOARTHRITIS AND CARTILAGE

Mitochondrial Metabolism Inhibitors for Cancer Therapy

(2011) Emma E. Ramsay et al.   PHARMACEUTICAL RESEARCH

The Human Serum Metabolome

(2011) Nikolaos Psychogios et al.   PLoS One

Diagnostic properties of metabolic perturbations in rheumatoid arthritis

(2011) Rasmus K Madsen et al.   ARTHRITIS RESEARCH & THERAPY

Identification of urinary metabolites that distinguish membranous lupus nephritis from proliferative lupus nephritis and focal segmental glomerulosclerosis

(2011) Lindsey E Romick-Rosendale et al.   ARTHRITIS RESEARCH & THERAPY

Metabolomic high-content nuclear magnetic resonance-based drug screening of a kinase inhibitor library

(2011) Stefano Tiziani et al.   Nature Communications

Advances in NMR-based biofluid analysis and metabolite profiling

(2010) Shucha Zhang et al.   ANALYST

Targeted Metabolomics for Biomarker Discovery

(2010) William J. Griffiths et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis

(2010) G. Zhai et al.   ANNALS OF THE RHEUMATIC DISEASES

Simvastatin induces derepression of PTEN expression via NFκB to inhibit breast cancer cell growth

(2010) Nayana Ghosh-Choudhury et al.   CELLULAR SIGNALLING

De NovoLipogenesis Maintains Vascular Homeostasis through Endothelial Nitric-oxide Synthase (eNOS) Palmitoylation

(2010) Xiaochao Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MassBank: a public repository for sharing mass spectral data for life sciences

(2010) Hisayuki Horai et al.   JOURNAL OF MASS SPECTROMETRY

Combination therapy targeting cancer metabolism

(2010) Justin B. Wenger et al.   MEDICAL HYPOTHESES

Sphingosine-1-phosphate: a potential therapeutic target for rheumatoid arthritis

(2010) Peng-fei Hu et al.   MOLECULAR BIOLOGY REPORTS

NMR of natural products at the ‘nanomole-scale’

(2010) Tadeusz F. Molinski   NATURAL PRODUCT REPORTS

Chemistry: Breaking the billion-hertz barrier

(2010) Ananyo Bhattacharya   NATURE

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models

(2009) W Schneiderhan et al.   GUT

Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)

(2009) Teresa WM Fan et al.   Molecular Cancer

Extracellular redox modulation by regulatory T cells

(2009) Zhonghua Yan et al.   Nature Chemical Biology

Integrated GC–MS and LC–MS plasma metabonomics analysis of ankylosing spondylitis

(2008) Peng Gao et al.   ANALYST

Highly sensitive feature detection for high resolution LC/MS

(2008) Ralf Tautenhahn et al.   BMC BIOINFORMATICS

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

International NMR-Based Environmental Metabolomics Intercomparison Exercise

(2008) Mark R. Viant et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Choline kinase as a link connecting phospholipid metabolism and cell cycle regulation: Implications in cancer therapy

(2008) Ana Ramírez de Molina et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Stable isotope-assisted metabolomics in cancer research

(2008) Andrew N. Lane et al.   IUBMB LIFE

Specific and overlapping sphingosine-1-phosphate receptor functions in human synoviocytes: impact of TNF-α

(2008) Chenqi Zhao et al.   JOURNAL OF LIPID RESEARCH

Update of the LIPID MAPS comprehensive classification system for lipids

(2008) Eoin Fahy et al.   JOURNAL OF LIPID RESEARCH

Metabolic Profiling of Human Colorectal Cancer Using High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance (HR-MAS NMR) Spectroscopy and Gas Chromatography Mass Spectrometry (GC/MS)

(2008) Eric Chun Yong Chan et al.   JOURNAL OF PROTEOME RESEARCH

Metabolite identification via the Madison Metabolomics Consortium Database

(2008) Qiu Cui et al.   NATURE BIOTECHNOLOGY

Lipid signalling in disease

(2008) Matthias P. Wymann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Quantitative metabolomics using NMR

(2008) David S. Wishart   TRAC-TRENDS IN ANALYTICAL CHEMISTRY