Journal
MEDICAL HYPOTHESES
Volume 76, Issue 2, Pages 169-172Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.mehy.2010.09.008
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Funding
- NCI NIH HHS [K22 CA111897-02, R21 CA115809, K22 CA111897-03, K22 CA111897, K22 CA111897-01A1] Funding Source: Medline
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Cancer cells undergo significant metabolic adaptation. Cellular transformation enhances both glycolysis and mitochondrial respiration efficiency through the induction of HIF-1 alpha and HIF-2 alpha. In this process, energy production and synthesis of macromolecules are maximized with minimal ROS accumulation. Furthermore, a series of antioxidant enzymes are induced to mitigate the damaging effects of ROS. Examination of these metabolic changes provides rationale for a synergistic approach to combination anti-cancer therapy; targeted inhibition of HIF and inhibition of cellular defenses against oxidative stress. Published by Elsevier Ltd.
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