Mitochondrial Metabolism Inhibitors for Cancer Therapy

Clotrimazole induces a late G1 cell cycle arrest and sensitizes glioblastoma cells to radiation in vitro

(2010) Hui Liu et al.   ANTI-CANCER DRUGS

Targeting glutamine metabolism sensitizes melanoma cells to TRAIL-induced death

(2010) J.-Z. Qin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

3-Bromopyruvate induces necrotic cell death in sensitive melanoma cell lines

(2010) J.-Z. Qin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of human VDAC isoforms: A peculiar function for VDAC3?

(2010) Vito De Pinto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Adenine nucleotide translocase 2 is a key mitochondrial protein in cancer metabolism

(2010) Arnaud Chevrollier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Oxidative phosphorylation in cancer cells

(2010) Giancarlo Solaini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Metabolic genes in cancer: Their roles in tumor progression and clinical implications

(2010) Eiji Furuta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis

(2010) V. A. Brown et al.   CANCER RESEARCH

Clinical Pharmacology of Resveratrol and Its Metabolites in Colorectal Cancer Patients

(2010) K. R. Patel et al.   CANCER RESEARCH

Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells

(2010) Meng Meng et al.   CELL CYCLE

Glutaminolysis: Supplying carbon or nitrogen or both for cancer cells?

(2010) Chi V. Dang   CELL CYCLE

Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree?

(2010) Jean-Pierre Bayley et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

3-Bromopyruvate: A New Targeted Antiglycolytic Agent and a Promise for Cancer Therapy

(2010) S. Ganapathy-Kanniappan et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Hexokinase inhibits flux of fluorescently labeled ATP through mitochondrial outer membrane porin

(2010) Irina V. Perevoshchikova et al.   FEBS LETTERS

The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cells

(2010) Cindy Gallerne et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC

(2010) Luke H. Stockwin et al.   INTERNATIONAL JOURNAL OF CANCER

Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?

(2010) Ioanna Papandreou et al.   INTERNATIONAL JOURNAL OF CANCER

Randomized Phase II Trial of All-Trans-Retinoic Acid With Chemotherapy Based on Paclitaxel and Cisplatin As First-Line Treatment in Patients With Advanced Non–Small-Cell Lung Cancer

(2010) Oscar Arrieta et al.   JOURNAL OF CLINICAL ONCOLOGY

The physiological regulation of glucose flux into muscle in vivo

(2010) D. H. Wasserman et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Succinate dehydrogenase – Assembly, regulation and role in human disease

(2010) Jared Rutter et al.   MITOCHONDRION

VDAC, a multi-functional mitochondrial protein regulating cell life and death

(2010) Varda Shoshan-Barmatz et al.   MOLECULAR ASPECTS OF MEDICINE

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Historic Perspectives on Annonaceous Acetogenins from the Chemical Bench to Preclinical Trials

(2010) Chih-Chuang Liaw et al.   PLANTA MEDICA

Modulation of Apoptosis by Natural Products for Cancer Therapy

(2010) Simone Fulda   PLANTA MEDICA

Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies

(2010) Mark Stein et al.   PROSTATE

A methyl jasmonate derivative, J-7, induces apoptosis in human hepatocarcinoma Hep3B cells in vitro

(2010) Cheol Park et al.   TOXICOLOGY IN VITRO

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism☆

(2009) Divya Pathania et al.   ADVANCED DRUG DELIVERY REVIEWS

Honokiol, a Multifunctional Antiangiogenic and Antitumor Agent

(2009) Levi E. Fried et al.   ANTIOXIDANTS & REDOX SIGNALING

The tumor suppressor function of mitochondria: Translation into the clinics

(2009) José M. Cuezva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The bioenergetics of cancer: Is glycolysis the main ATP supplier in all tumor cells?

(2009) Rafael Moreno-Sánchez et al.   BIOFACTORS

The impact on outcome of the addition of all-trans retinoic acid to intensive chemotherapy in younger patients with nonacute promyelocytic acute myeloid leukemia: overall results and results in genotypic subgroups defined by mutations in NPM1, FLT3, and CEBPA

(2009) A. K. Burnett et al.   BLOOD

Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo

(2009) Ramon C. Sun et al.   BREAST CANCER RESEARCH AND TREATMENT

Minerals and vitamins and the risk of bladder cancer: results from the New Hampshire Study

(2009) Maree T. Brinkman et al.   CANCER CAUSES & CONTROL

UOK 262 cell line, fumarate hydratase deficient (FH−/FH−) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer

(2009) Youfeng Yang et al.   CANCER GENETICS AND CYTOGENETICS

Glutamine homeostasis and mitochondrial dynamics

(2009) José M. Matés et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Preparation of MPEG–PLA nanoparticle for honokiol delivery in vitro

(2009) XiuLing Zheng et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Optimization of the Antitumor Efficacy of a Synthetic Mitochondrial Toxin by Increasing the Residence Time in the Cytosol

(2009) Pierre J. Dilda et al.   JOURNAL OF MEDICINAL CHEMISTRY

Relationship Between Expression of Voltage-Dependent Anion Channel (VDAC) Isoforms and Type of Hexokinase Binding Sites on Brain Mitochondria

(2009) Mirele Daiana Poleti et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Mitochondria as targets in angiogenesis inhibition

(2009) Danielle Park et al.   MOLECULAR ASPECTS OF MEDICINE

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Methyl jasmonate: A plant stress hormone as an anti-cancer drug

(2009) Sharon Cohen et al.   PHYTOCHEMISTRY

SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma

(2009) H.-X. Hao et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Bioreductive activation of quinone antitumor drugs by mitochondrial voltage-dependent anion channel 1

(2008) Eriko Simamura et al.   ANATOMICAL SCIENCE INTERNATIONAL

Expression and localization of voltage-dependent anion channels (VDAC) in human spermatozoa

(2008) Bianjiang Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate1

(2008) Ana Paula Pereira Da Silva et al.   BIOCHEMICAL JOURNAL

Development of mitochondria-targeted derivatives of resveratrol

(2008) Lucia Biasutto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular and functional characterization of VDAC2 purified from mammal spermatozoa

(2008) Viviana A. Menzel et al.   BIOSCIENCE REPORTS

PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer

(2008) S M Wigfield et al.   BRITISH JOURNAL OF CANCER

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Roles of p53, Myc and HIF-1 in Regulating Glycolysis — the Seventh Hallmark of Cancer

(2008) S. J. Yeung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Honokiol, a natural therapeutic candidate, induces apoptosis and inhibits angiogenesis of ovarian tumor cells

(2008) Zhengyu Li et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Glycolytic enzyme inhibitors in cancer treatment

(2008) Roberto Scatena et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Dichloroacetate induces apoptosis in endometrial cancer cells

(2008) Jason Y.Y. Wong et al.   GYNECOLOGIC ONCOLOGY

Vitamin E and cancer: An insight into the anticancer activities of vitamin E isomers and analogs

(2008) Constantina Constantinou et al.   INTERNATIONAL JOURNAL OF CANCER

Betulinic Acid for Cancer Treatment and Prevention

(2008) Simone Fulda   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of hexokinase binding to VDAC

(2008) John G. Pastorino et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Metabolism of the Tumor Angiogenesis Inhibitor 4-(N-(S-Glutathionylacetyl)amino)phenylarsonous Acid

(2008) Pierre J. Dilda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Benzyl Isothiocyanate Targets Mitochondrial Respiratory Chain to Trigger Reactive Oxygen Species-dependent Apoptosis in Human Breast Cancer Cells

(2008) Dong Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells

(2008) Thomas McFate et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Voltage-dependent Anion Channel 1-based Peptides Interact with Hexokinase to Prevent Its Anti-apoptotic Activity

(2008) Laetitia Arzoine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vitamin E analogues as mitochondria-targeting compounds: From the bench to the bedside?

(2008) Yan Zhao et al.   MOLECULAR NUTRITION & FOOD RESEARCH

3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs

(2008) Linda Strandberg Ihrlund et al.   Molecular Oncology

Molecular architecture of native HIV-1 gp120 trimers

(2008) Jun Liu et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Methyl jasmonate binds to and detaches mitochondria-bound hexokinase

(2008) N Goldin et al.   ONCOGENE

α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II

(2008) L-F Dong et al.   ONCOGENE

Dichloroacetate (DCA) sensitizes both wild‐type and over expressingBcl‐2prostate cancer cells in vitro to radiation

(2008) Wengang Cao et al.   PROSTATE

Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy

(2008) Saroj P. Mathupala et al.   SEMINARS IN CANCER BIOLOGY