Mutational Analysis of the Integral Membrane Methyltransferase Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Reveals Potential Substrate Binding Sites

An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo

(2014) Hiu Yeung Lau et al.   CANCER BIOLOGY & THERAPY

Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression

(2013) Helen Court et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural Studies of AntD: An N-Acyltransferase Involved in the Biosynthesis of d-Anthrose

(2012) Rachel L. Kubiak et al.   BIOCHEMISTRY

Discovery and SAR of Methylated Tetrahydropyranyl Derivatives as Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase (ICMT)

(2011) Weston R. Judd et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanism of Isoprenylcysteine Carboxyl Methylation from the Crystal Structure of the Integral Membrane Methyltransferase ICMT

(2011) Jing Yang et al.   MOLECULAR CELL

Phenylalanine 93 of the human UGT1A10 plays a major role in the interactions of the enzyme with estrogens

(2011) Camilla Höglund et al.   STEROIDS

The biological significance of substrate inhibition: A mechanism with diverse functions

(2010) Michael C. Reed et al.   BIOESSAYS

Functional Oligomerization of the Saccharomyces cerevisiae Isoprenylcysteine Carboxyl Methyltransferase, Ste14p

(2010) Amy M. Griggs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth

(2010) M Wang et al.   ONCOGENE

Role of Isoprenylcysteine Carboxylmethyltransferase-catalyzed Methylation in Rho Function and Migration

(2009) Ian Cushman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Topology of Mammalian Isoprenylcysteine Carboxyl Methyltransferase Determined in Live Cells with a Fluorescent Probe

(2009) L. P. Wright et al.   MOLECULAR AND CELLULAR BIOLOGY

Inactivating Icmt ameliorates K-RAS-induced myeloproliferative disease

(2008) A. M. Wahlstrom et al.   BLOOD

A Small Molecule Inhibitor of Isoprenylcysteine Carboxymethyltransferase Induces Autophagic Cell Death in PC3 Prostate Cancer Cells

(2008) Mei Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Jpred 3 secondary structure prediction server

(2008) C. Cole et al.   NUCLEIC ACIDS RESEARCH