标题
Protein prenylation: unique fats make their mark on biology
作者
关键词
-
出版物
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 17, Issue 2, Pages 110-122
出版商
Springer Nature
发表日期
2016-01-21
DOI
10.1038/nrm.2015.11
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?
- (2015) A. D. Cox et al. CLINICAL CANCER RESEARCH
- mTOR: a pharmacologic target for autophagy regulation
- (2015) Young Chul Kim et al. JOURNAL OF CLINICAL INVESTIGATION
- Oral prenylation inhibition with lonafarnib in chronic hepatitis D infection: a proof-of-concept randomised, double-blind, placebo-controlled phase 2A trial
- (2015) Christopher Koh et al. LANCET INFECTIOUS DISEASES
- An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo
- (2014) Hiu Yeung Lau et al. CANCER BIOLOGY & THERAPY
- Progeria: A Paradigm for Translational Medicine
- (2014) Leslie B. Gordon et al. CELL
- Impact of Farnesylation Inhibitors on Survival in Hutchinson-Gilford Progeria Syndrome
- (2014) Leslie B. Gordon et al. CIRCULATION
- Mutational Analysis of the Integral Membrane Methyltransferase Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Reveals Potential Substrate Binding Sites
- (2014) Melinda M. Diver et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Chaperone Protein SmgGDS Interacts with Small GTPases Entering the Prenylation Pathway by Recognizing the Last Amino Acid in the CAAXMotif
- (2014) Nathan J. Schuld et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A combination of metabolic labeling and 2D-DIGE analysis in response to a farnesyltransferase inhibitor facilitates the discovery of new prenylated proteins
- (2014) Charuta C. Palsuledesai et al. Molecular BioSystems
- Inhibiting Geranylgeranylation Increases Neurite Branching and Differentially Activates Cofilin in Cell Bodies and Growth Cones
- (2014) Filsy Samuel et al. MOLECULAR NEUROBIOLOGY
- Protein Prenylation and Synaptic Plasticity: Implications for Alzheimer’s Disease
- (2014) David A. Hottman et al. MOLECULAR NEUROBIOLOGY
- Metabolic control of YAP and TAZ by the mevalonate pathway
- (2014) Giovanni Sorrentino et al. NATURE CELL BIOLOGY
- Drugging the undruggable RAS: Mission Possible?
- (2014) Adrienne D. Cox et al. NATURE REVIEWS DRUG DISCOVERY
- YAP and TAZ under metabolic control
- (2014) Katharine H. Wrighton NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism
- (2014) J T Teh et al. ONCOGENE
- Investigation of LKB1 Ser431phosphorylation and Cys433farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity
- (2013) Vanessa P. Houde et al. BIOCHEMICAL JOURNAL
- Topology of the Yeast Ras Converting Enzyme As Inferred from Cysteine Accessibility Studies
- (2013) Emily R. Hildebrandt et al. BIOCHEMISTRY
- 14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins
- (2013) Philippe Riou et al. CELL
- Control of RhoA Methylation by Carboxylesterase I
- (2013) Ian Cushman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Farnesyltransferase Haplodeficiency Reduces Neuropathology and Rescues Cognitive Function in a Mouse Model of Alzheimer Disease
- (2013) Shaowu Cheng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression
- (2013) Helen Court et al. JOURNAL OF CLINICAL INVESTIGATION
- Identification of a Novel Prenyl and Palmitoyl Modification at the CaaX Motif of Cdc42 That Regulates RhoGDI Binding
- (2013) A. Nishimura et al. MOLECULAR AND CELLULAR BIOLOGY
- Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1
- (2013) Ioannis Manolaridis et al. NATURE
- Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling
- (2013) Gunther Zimmermann et al. NATURE
- Transformation by HrasG12V is consistently associated with mutant allele copy gains and is reversed by farnesyl transferase inhibition
- (2013) X Chen et al. ONCOGENE
- Targeting Isoprenylcysteine Methylation Ameliorates Disease in a Mouse Model of Progeria
- (2013) M. X. Ibrahim et al. SCIENCE
- An Adenosine-Mediated Signaling Pathway Suppresses Prenylation of the GTPase Rap1B and Promotes Cell Scattering
- (2013) E. Ntantie et al. Science Signaling
- Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors
- (2013) Stephen A. Adam et al. Nucleus
- Geranylgeranyl transferase regulates CXC chemokine formation in alveolar macrophages and neutrophil recruitment in septic lung injury
- (2012) Zirak Hasan et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Recent advances in protein prenyltransferases: substrate identification, regulation, and disease interventions
- (2012) Elaina A Zverina et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Prenylation of Rho G-Proteins: a Novel Mechanism Regulating Gene Expression and Protein Stability in Human Trabecular Meshwork Cells
- (2012) Evan B. Stubbs et al. MOLECULAR NEUROBIOLOGY
- The role of nuclear lamin B1 in cell proliferation and senescence
- (2011) T. Shimi et al. GENES & DEVELOPMENT
- A Role for Rac3 GTPase in the Regulation of Autophagy
- (2011) Wan Long Zhu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice
- (2011) Omar M. Khan et al. JOURNAL OF CLINICAL INVESTIGATION
- Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts
- (2011) Kan Cao et al. JOURNAL OF CLINICAL INVESTIGATION
- Discovery and SAR of Methylated Tetrahydropyranyl Derivatives as Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase (ICMT)
- (2011) Weston R. Judd et al. JOURNAL OF MEDICINAL CHEMISTRY
- Mechanism of Isoprenylcysteine Carboxyl Methylation from the Crystal Structure of the Integral Membrane Methyltransferase ICMT
- (2011) Jing Yang et al. MOLECULAR CELL
- Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo
- (2011) Shehab A Ismail et al. Nature Chemical Biology
- Regulating the regulator: post-translational modification of RAS
- (2011) Ian M. Ahearn et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments
- (2011) J. R. Christiansen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Perspective on Cancer Cell Metastasis
- (2011) C. L. Chaffer et al. SCIENCE
- S-Farnesyl-Thiopropionic Acid Triazoles as Potent Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase
- (2011) Joel A. Bergman et al. ACS Medicinal Chemistry Letters
- Isoprenoids, small GTPases and Alzheimer's disease
- (2010) Gero P. Hooff et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Multiple Cellular Proteins Modulate the Dynamics of K-ras Association with the Plasma Membrane
- (2010) Pinkesh Bhagatji et al. BIOPHYSICAL JOURNAL
- Statin myopathy: a review of recent progress
- (2010) Andrew L Mammen et al. CURRENT OPINION IN RHEUMATOLOGY
- Farnesyltransferase inhibitors: where are we now?
- (2010) Apostolia Maria Tsimberidou et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin
- (2010) Shao H. Yang et al. HUMAN MOLECULAR GENETICS
- Functional Oligomerization of the Saccharomyces cerevisiae Isoprenylcysteine Carboxyl Methyltransferase, Ste14p
- (2010) Amy M. Griggs et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Splice Variants of SmgGDS Control Small GTPase Prenylation and Membrane Localization
- (2010) Tracy J. Berg et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Novel Geranylgeranyl Transferase Inhibitor in Combination with Lovastatin Inhibits Proliferation and Induces Autophagy in STS-26T MPNST Cells
- (2010) K. M. Sane et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- The chemical toolbox for monitoring protein fatty acylation and prenylation
- (2010) Rami N Hannoush et al. Nature Chemical Biology
- Epidemiology, pathogenesis and management of hepatitis D: update and challenges ahead
- (2010) Heiner Wedemeyer et al. Nature Reviews Gastroenterology & Hepatology
- Small G Protein Signaling in Neuronal Plasticity and Memory Formation: The Specific Role of Ras Family Proteins
- (2010) Xiaojing Ye et al. NEURON
- Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth
- (2010) M Wang et al. ONCOGENE
- Lovastatin inhibits EGFR dimerization and AKT activation in squamous cell carcinoma cells: potential regulation by targeting rho proteins
- (2010) T T Zhao et al. ONCOGENE
- Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer
- (2010) M. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- GTPases involved in vesicular trafficking: Structures and mechanisms
- (2010) Aymelt Itzen et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Farnesyltransferase inhibitors-induced autophagy: Alternative mechanisms?
- (2009) Jingxuan Pan et al. Autophagy
- Structural Basis for Binding and Selectivity of Antimalarial and Anticancer Ethylenediamine Inhibitors to Protein Farnesyltransferase
- (2009) Michael A. Hast et al. CHEMISTRY & BIOLOGY
- Role of Isoprenylcysteine Carboxylmethyltransferase-catalyzed Methylation in Rho Function and Migration
- (2009) Ian Cushman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of Novel Peptide Substrates for Protein Farnesyltransferase Reveals Two Substrate Classes with Distinct Sequence Selectivities
- (2009) James L. Hougland et al. JOURNAL OF MOLECULAR BIOLOGY
- Topology of Mammalian Isoprenylcysteine Carboxyl Methyltransferase Determined in Live Cells with a Fluorescent Probe
- (2009) L. P. Wright et al. MOLECULAR AND CELLULAR BIOLOGY
- In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I
- (2009) J. Lu et al. MOLECULAR CANCER THERAPEUTICS
- Observation of an Efimov-like trimer resonance in ultracold atom–dimer scattering
- (2009) S. Knoop et al. Nature Physics
- Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling
- (2009) A B Hanker et al. ONCOGENE
- Inactivating Icmt ameliorates K-RAS-induced myeloproliferative disease
- (2008) A. M. Wahlstrom et al. BLOOD
- Autophagy in aging, disease and death: the true identity of a cell death impostor
- (2008) B Levine et al. CELL DEATH AND DIFFERENTIATION
- Farnesyltransferase Inhibitors: A Detailed Chemical View on an Elusive Biological Problem
- (2008) Sergio Sousa et al. CURRENT MEDICINAL CHEMISTRY
- Liver prenylated methylated protein methyl esterase is the same enzyme assus scrofa carboxylesterase
- (2008) Onovughode T. Oboh et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Identification of Essential Interacting Elements in K-Ras/Calmodulin Binding and Its Role in K-Ras Localization
- (2008) Cristina Lopez-Alcalá et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Small Molecule Inhibitor of Isoprenylcysteine Carboxymethyltransferase Induces Autophagic Cell Death in PC3 Prostate Cancer Cells
- (2008) Mei Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mammalian Rho GTPases: new insights into their functions from in vivo studies
- (2008) Sarah J. Heasman et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Isoprenylcysteine Methylation and Demethylation Regulate Abscisic Acid Signaling in Arabidopsis
- (2008) D. H. Huizinga et al. PLANT CELL
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started