STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages

Immune phenotypic linkage between colorectal cancer and liver metastasis

(2022) Yedan Liu et al.   CANCER CELL

Itaconate is a lysosomal inducer that promotes antibacterial innate immunity

(2022) Zhenxing Zhang et al.   MOLECULAR CELL

Aconitate decarboxylase 1 is a mediator of polymicrobial sepsis

(2022) Runliu Wu et al.   Science Translational Medicine

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level

(2021) Yingcheng Wu et al.   Cancer Discovery

Tumor-associated macrophages

(2020) Luca Cassetta et al.   CURRENT BIOLOGY

ACOD1 in immunometabolism and disease

(2020) Runliu Wu et al.   Cellular & Molecular Immunology

Electrophilic Nrf2 activators and itaconate inhibit inflammation at low dose and promote IL-1β production and inflammatory apoptosis at high dose

(2020) Jonathan Muri et al.   Redox Biology

Tumor microenvironment as a therapeutic target in cancer

(2020) Yi Xiao et al.   PHARMACOLOGY & THERAPEUTICS

Macrophages and Metabolism in the Tumor Microenvironment

(2019) Ilio Vitale et al.   Cell Metabolism

CFTR-PTEN–dependent mitochondrial metabolic dysfunction promotes Pseudomonas aeruginosa airway infection

(2019) Sebastián A. Riquelme et al.   Science Translational Medicine

TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells

(2019) Ruizhi He et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Colorectal cancer

(2019) Evelien Dekker et al.   LANCET

The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

(2019) John Kwon et al.   Cancer Discovery

Reduced oxidative capacity in macrophages results in systemic insulin resistance

(2018) Saet-Byel Jung et al.   Nature Communications

Notch Signaling in the Tumor Microenvironment

(2018) Olivier Meurette et al.   CANCER CELL

Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors

(2018) Jonathan M. Weiss et al.   JOURNAL OF CLINICAL INVESTIGATION

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages

(2017) Jennifer L. Guerriero et al.   NATURE

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

Recurrent Loss of STING Signaling in Melanoma Correlates with Susceptibility to Viral Oncolysis

(2016) Tianli Xia et al.   CANCER RESEARCH

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Erratum: Corrigendum: PI3Kγ is a molecular switch that controls immune suppression

(2016) Megan M. Kaneda et al.   NATURE

The regulation of immune cell trafficking by the extracellular matrix

(2015) Rupert Hallmann et al.   CURRENT OPINION IN CELL BIOLOGY

Macrophage polarization in response to ECM coated polypropylene mesh

(2014) Matthew T. Wolf et al.   BIOMATERIALS

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

(2013) Xu Zhang et al.   MOLECULAR CELL

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE