Aconitate decarboxylase 1 is a mediator of polymicrobial sepsis

Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation

(2021) Kira L. Tomlinson et al.   Nature Communications

Cyclin-Dependent Kinases (CDK) and Their Role in Diseases Development–Review

(2021) Paweł Łukasik et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The GIMAP Family Proteins: An Incomplete Puzzle

(2021) Marc-André Limoges et al.   Frontiers in Immunology

IRG1/Itaconate Activates Nrf2 in Hepatocytes to Protect Against Liver Ischemia–Reperfusion Injury

(2020) Zhongjie Yi et al.   HEPATOLOGY

Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

(2020) Kristina E Rudd et al.   LANCET

TMEM173 Drives Lethal Coagulation in Sepsis

(2020) Hui Zhang et al.   Cell Host & Microbe

ACOD1 in immunometabolism and disease

(2020) Runliu Wu et al.   Cellular & Molecular Immunology

Development of ion pairing LC-MS/MS method for itaconate and cis-aconitate in cell extract and cell media

(2020) Bo Tan et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signalling

(2020) Borong Zhou et al.   Nature Microbiology

Itaconate controls the severity of pulmonary fibrosis

(2020) Patricia P. Ogger et al.   Science Immunology

Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration

(2019) Alan Y. Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Irg1expression in myeloid cells prevents immunopathology duringM. tuberculosisinfection

(2018) Sharmila Nair et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cyclin-dependent kinase activity is required for type I interferon production

(2018) Oya Cingöz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis

(2018) Wenjun Deng et al.   Cell Reports

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

(2018) Monika Bambouskova et al.   NATURE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Metabolism as a guiding force for immunity

(2018) Jonathan Jung et al.   NATURE CELL BIOLOGY

ALK is a therapeutic target for lethal sepsis

(2017) Ling Zeng et al.   Science Translational Medicine

A novel PINK1- and PARK2-dependent protective neuroimmune pathway in lethal sepsis

(2016) Rui Kang et al.   Autophagy

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation

(2016) A. Rialdi et al.   SCIENCE

Current Murine Models of Sepsis

(2016) Anthony J. Lewis et al.   Surgical Infections

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid

(2016) Jan Naujoks et al.   PLoS Pathogens

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis

(2014) Liangchun Yang et al.   Nature Communications

Randomized Phase II Trial of the Cyclin-Dependent Kinase Inhibitor Dinaciclib (MK-7965) Versus Capecitabine in Patients With Advanced Breast Cancer

(2013) Monica M. Mita et al.   Clinical Breast Cancer

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Host innate immune responses to sepsis

(2013) Willem Joost Wiersinga et al.   Virulence

The Proinflammatory Cytokine-Induced IRG1 Protein Associates with Mitochondria

(2008) Daniel Degrandi et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH