CFTR-PTEN–dependent mitochondrial metabolic dysfunction promotes Pseudomonas aeruginosa airway infection

Personalized medicine in CF: from modulator development to therapy for cystic fibrosis patients with rare CFTR mutations

(2018) Misak Harutyunyan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Disruption of IDH2 attenuates lipopolysaccharide-induced inflammation and lung injury in an α-ketoglutarate-dependent manner

(2018) Jung Hyun Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting Antibiotic Tolerance, Pathogen by Pathogen

(2018) Sylvain Meylan et al.   CELL

Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten -Null Cells

(2018) Adam Naguib et al.   Cell Reports

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

(2018) Michael P. Murphy et al.   CELL

Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors

(2018) Jonathan M. Weiss et al.   JOURNAL OF CLINICAL INVESTIGATION

High-Resolution Magic Angle Spinning NMR-Based Metabolomics Revealing Metabolic Changes in Lung of Mice Infected with P. aeruginosa Consistent with the Degree of Disease Severity

(2018) Audrey LeGouëllec et al.   JOURNAL OF PROTEOME RESEARCH

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Great phenotypic and genetic variation among successive chronic Pseudomonas aeruginosa from a cystic fibrosis patient

(2018) Carmen Lozano et al.   PLoS One

Cystic Fibrosis Transmembrane Conductance Regulator Attaches Tumor Suppressor PTEN to the Membrane and Promotes Anti Pseudomonas aeruginosa Immunity

(2017) Sebastián A. Riquelme et al.   IMMUNITY

Metabolic defence against oxidative stress: the road less travelled so far

(2017) J. Lemire et al.   JOURNAL OF APPLIED MICROBIOLOGY

CFTR Modulator Therapy for Cystic Fibrosis

(2017) Hartmut Grasemann   NEW ENGLAND JOURNAL OF MEDICINE

IDH3 mediates apoptosis of alveolar epithelial cells type 2 due to mitochondrial Ca2+ uptake during hypocapnia

(2017) Martina Kiefmann et al.   Cell Death & Disease

Cyclic-di-GMP regulates lipopolysaccharide modification and contributes to Pseudomonas aeruginosa immune evasion

(2017) Ronan R. McCarthy et al.   Nature Microbiology

Oxidation of NADH and ROS production by respiratory complex I

(2016) Andrei D. Vinogradov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

(2016) Thekla Cordes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biofilms and Cyclic di-GMP (c-di-GMP) Signaling: Lessons fromPseudomonas aeruginosaand Other Bacteria

(2016) Martina Valentini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Glyoxylate Shunt in Oxidative Stress Response

(2016) Sungeun Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF1α and metabolic reprogramming in inflammation

(2016) Sarah E. Corcoran et al.   JOURNAL OF CLINICAL INVESTIGATION

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

(2016) Amanda Littlewood-Evans et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cystic fibrosis

(2016) J Stuart Elborn   LANCET

Advancing clinical development pathways for new CFTR modulators in cystic fibrosis

(2016) Nicole Mayer-Hamblett et al.   THORAX

Pseudomonas aeruginosa Evolutionary Adaptation and Diversification in Cystic Fibrosis Chronic Lung Infections

(2016) Craig Winstanley et al.   TRENDS IN MICROBIOLOGY

IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis

(2016) Rossana G. Iannitti et al.   Nature Communications

Reactive oxygen species drive evolution of pro-biofilm variants in pathogens by modulating cyclic-di-GMP levels

(2016) Song Lin Chua et al.   Open Biology

Animal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and Divergences

(2016) Gillian M. Lavelle et al.   Biomed Research International

Role of PTEN in Oxidative Stress and DNA Damage in the Liver of Whole-Body Pten Haplodeficient Mice

(2016) Ezgi Eyluel Bankoglu et al.   PLoS One

Pseudomonas aeruginosa MifS-MifR Two-Component System Is Specific for α-Ketoglutarate Utilization

(2015) Gorakh Tatke et al.   PLoS One

Ferret and Pig Models of Cystic Fibrosis: Prospects and Promise for Gene Therapy

(2015) Ziying Yan et al.   Human Gene Therapy Clinical Development

PTENα, a PTEN Isoform Translated through Alternative Initiation, Regulates Mitochondrial Function and Energy Metabolism

(2014) Hui Liang et al.   Cell Metabolism

Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis

(2014) Rasmus Lykke Marvig et al.   NATURE GENETICS

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

Fosfomycin and Tobramycin in Combination Downregulate Nitrate Reductase GenesnarGandnarH, Resulting in Increased Activity against Pseudomonas aeruginosa under Anaerobic Conditions

(2013) Gerard McCaughey et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

ROS generation and multiple forms of mammalian mitochondrial glycerol-3-phosphate dehydrogenase

(2013) Tomáš Mráček et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Signaling Regulates Mitochondrial Biogenesis and Respiration via Estrogen-related Receptor α (ERRα)

(2013) Yang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of inflammasome signaling mediates pathology of acute P. aeruginosa pneumonia

(2013) Taylor S. Cohen et al.   JOURNAL OF CLINICAL INVESTIGATION

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

A Secreted PTEN Phosphatase That Enters Cells to Alter Signaling and Survival

(2013) B. D. Hopkins et al.   SCIENCE

Elevated plasma succinate in PTEN, SDHB and SDHD mutation–positive individuals

(2012) Judith A. Hobert et al.   GENETICS IN MEDICINE

Clinical populations of Pseudomonas aeruginosa isolated from acute infections show a wide virulence range partially correlated with population structure and virulence gene expression

(2012) H. A. Janjua et al.   MICROBIOLOGY-SGM

PTEN in cancer, metabolism, and aging

(2012) Ana Ortega-Molina et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

(2010) Alessandro Luciani et al.   NATURE CELL BIOLOGY

Loss of function of PTEN alters the relationship between glucose concentration and cell proliferation, increases glycolysis, and sensitizes cells to 2-deoxyglucose

(2009) Marie-José Blouin et al.   CANCER LETTERS

Pseudomonas aeruginosa Rugose Small-Colony Variants Have Adaptations That Likely Promote Persistence in the Cystic Fibrosis Lung

(2009) M. Starkey et al.   JOURNAL OF BACTERIOLOGY

Carbon catabolite repression in bacteria: many ways to make the most out of nutrients

(2008) Boris Görke et al.   NATURE REVIEWS MICROBIOLOGY