C-176 loaded Ce DNase nanoparticles synergistically inhibit the cGAS-STING pathway for ischemic stroke treatment

Asparagine endopeptidase-targeted Ultrasound-responsive Nanobubbles Alleviate Tau Cleavage and Amyloid-β Deposition in an Alzheimer's Disease Model

(2022) Xue Mi et al.   Acta Biomaterialia

A nanoparticulate dual scavenger for targeted therapy of inflammatory bowel disease

(2022) Chengxin Shi et al.   Science Advances

Enhanced treatment of cerebral ischemia–Reperfusion injury by intelligent nanocarriers through the regulation of neurovascular units

(2022) Hongdan Lu et al.   Acta Biomaterialia

Sensitive Activatable Nanoprobes for Real‐Time Ratiometric Magnetic Resonance Imaging of Reactive Oxygen Species and Ameliorating Inflammation In Vivo

(2022) Xilan Li et al.   ADVANCED MATERIALS

Supramolecular hydrogel-loaded Prussian blue nanoparticles with photothermal and ROS scavenging ability for tumor postoperative treatments

(2022) Zongrui Tong et al.   COMPOSITES PART B-ENGINEERING

Nanoparticulate DNA scavenger loading methotrexate targets articular inflammation to enhance rheumatoid arthritis treatment

(2022) Xingliang Liu et al.   BIOMATERIALS

ROS-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation

(2022) Lulu Jin et al.   Bioactive Materials

Dimethylamino group modified polydopamine nanoparticles with positive charges to scavenge cell-free DNA for rheumatoid arthritis therapy

(2022) Ying Chen et al.   Bioactive Materials

Neutrophil-like Cell-Membrane-Coated Nanozyme Therapy for Ischemic Brain Damage and Long-Term Neurological Functional Recovery

(2021) Lishuai Feng et al.   ACS Nano

A Cationic Metal–Organic Framework to Scavenge Cell-Free DNA for Severe Sepsis Management

(2021) Feng Liu et al.   NANO LETTERS

Edaravone Dexborneol Versus Edaravone Alone for the Treatment of Acute Ischemic Stroke

(2021) Jie Xu et al.   STROKE

Erythrocyte Membrane-Camouflaged PCN-224 Nanocarriers Integrated with Platinum Nanoparticles and Glucose Oxidase for Enhanced Tumor Sonodynamic Therapy and Synergistic Starvation Therapy

(2021) Yuheng Bao et al.   ACS Applied Materials & Interfaces

Topical cationic hairy particles targeting cell free DNA in dermis enhance treatment of psoriasis

(2021) Yanzi Yan et al.   BIOMATERIALS

Recent advances in the development of nanomedicines for the treatment of ischemic stroke

(2021) Xing Tian et al.   Bioactive Materials

Recent Advances in Nanozymes: From Matters to Bioapplications

(2021) Yongjian Ai et al.   ADVANCED FUNCTIONAL MATERIALS

Cytoplasmic DNA: sources, sensing, and role in aging and disease

(2021) Karl N. Miller et al.   CELL

DNase I functional microgels for neutrophil extracellular trap disruption

(2021) Aisa Hosseinnejad et al.   Biomaterials Science

Construction of heparin-based hydrogel incorporated with Cu5.4O ultrasmall nanozymes for wound healing and inflammation inhibition

(2021) Yuan Peng et al.   Bioactive Materials

Evaluation of neutrophil extracellular traps as the circulating marker for patients with acute coronary syndrome and acute ischemic stroke

(2020) Hyeon‐Ho Lim et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Cationic Block Copolymer Nanoparticles with Tunable DNA Affinity for Treating Rheumatoid Arthritis

(2020) Jingjiao Wu et al.   ADVANCED FUNCTIONAL MATERIALS

Inhibition of double‐strand DNA‐sensing cGAS ameliorates brain injury after ischemic stroke

(2020) Qian Li et al.   EMBO Molecular Medicine

Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage

(2020) Yucong Peng et al.   Journal of Neuroinflammation

Treatment of severe sepsis with nanoparticulate cell-free DNA scavengers

(2020) Jianati Dawulieti et al.   Science Advances

Protein Dynamics in Cytosolic DNA-Sensing Antiviral Innate Immune Signaling Pathways

(2020) Chunfu Zheng   Frontiers in Immunology

Long-acting nanoparticulate DNase-1 for effective suppression of SARS-CoV-2-mediated neutrophil activities and cytokine storm

(2020) Yun Young Lee et al.   BIOMATERIALS

Targeting the Immune System for Ischemic Stroke

(2020) Shenpeng R. Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA

(2019) Katherine C. Barnett et al.   CELL

Tuned Cationic Dendronized Polymer: Molecular Scavenger for Rheumatoid Arthritis Treatment

(2019) Bo Peng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stroke in China: advances and challenges in epidemiology, prevention, and management

(2019) Simiao Wu et al.   LANCET NEUROLOGY

Sequentially Site-Specific Delivery of Thrombolytics and Neuroprotectant for Enhanced Treatment of Ischemic Stroke

(2019) Jianpei Xu et al.   ACS Nano

A series of MOF/Ce-based nanozymes with dual enzyme-like activity disrupting biofilms and hindering recolonization of bacteria

(2019) Zhengwei Liu et al.   BIOMATERIALS

Global brain inflammation in stroke

(2019) Kaibin Shi et al.   LANCET NEUROLOGY

A Tug of War: DNA-Sensing Antiviral Innate Immunity and Herpes Simplex Virus Type I Infection

(2019) Yingying Lin et al.   Frontiers in Microbiology

β-Catenin Is Required for the cGAS/STING Signaling Pathway but Antagonized by the Herpes Simplex Virus 1 US3 Protein

(2019) Hongjuan You et al.   JOURNAL OF VIROLOGY

Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance

(2018) Wen Zhou et al.   CELL

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

(2018) Akiko Takahashi et al.   Nature Communications

TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia

(2018) Parul H. Kothari et al.   BRAIN PATHOLOGY

Targeting STING with covalent small-molecule inhibitors

(2018) Simone M. Haag et al.   NATURE

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation

(2018) Huiyi Liang et al.   Nature Communications

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

A Multinuclear Metal Complex Based DNase-Mimetic Artificial Enzyme: Matrix Cleavage for Combating Bacterial Biofilms

(2016) Zhaowei Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Immune interventions in stroke

(2015) Ying Fu et al.   Nature Reviews Neurology

Coordinated Effects of Sequence Variation on DNA Binding, Chromatin Structure, and Transcription

(2013) H. Kilpinen et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Phosphate diesters cleavage mediated by Ce(iv) complexes self-assembled on gold nanoparticles

(2010) Renato Bonomi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Phosphate Diester and DNA Hydrolysis by a Multivalent, Nanoparticle-Based Catalyst

(2008) Renato Bonomi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY