Asparagine endopeptidase-targeted Ultrasound-responsive Nanobubbles Alleviate Tau Cleavage and Amyloid-β Deposition in an Alzheimer's Disease Model

Pharmacological inhibition of asparaginyl endopeptidase by δ-secretase inhibitor 11 mitigates Alzheimer’s disease-related pathologies in a senescence-accelerated mouse model

(2021) Ju Wang et al.   Translational Neurodegeneration

An Advanced In Situ Magnetic Resonance Imaging and Ultrasonic Theranostics Nanocomposite Platform: Crossing the Blood–Brain Barrier and Improving the Suppression of Glioblastoma Using Iron-Platinum Nanoparticles in Nanobubbles

(2021) Ming-Hsien Chan et al.   ACS Applied Materials & Interfaces

Near-infrared target enhanced peripheral clearance of amyloid-β in Alzheimer's disease model

(2021) Mengmeng Ma et al.   BIOMATERIALS

δ-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities

(2020) Zhentao Zhang et al.   Translational Neurodegeneration

Ultrasound-mediated diagnostic imaging and advanced treatment with multifunctional micro/nanobubbles

(2020) Jiaping Li et al.   CANCER LETTERS

Molecular Ultrasound Imaging

(2020) Gurbet Köse et al.   Nanomaterials

Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

(2019) Jinbing Xie et al.   BIOMATERIALS

Clinical Research on Alzheimer’s Disease: Progress and Perspectives

(2018) Bin-Lu Sun et al.   Neuroscience Bulletin

Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease

(2017) Zhentao Zhang et al.   Nature Communications

Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer’s Disease

(2016) Hyek Jin Kwon et al.   ACS Nano

Structure and function of legumain in health and disease

(2016) Elfriede Dall et al.   BIOCHIMIE

Brain-targeted co-delivery of therapeutic gene and peptide by multifunctional nanoparticles in Alzheimer's disease mice

(2016) Yang Liu et al.   BIOMATERIALS

Asparagine endopeptidase is an innovative therapeutic target for neurodegenerative diseases

(2016) Zhentao Zhang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Defeating Alzheimer's disease and other dementias: a priority for European science and society

(2016) Bengt Winblad et al.   LANCET NEUROLOGY

Nanobubble–Affibody: Novel ultrasound contrast agents for targeted molecular ultrasound imaging of tumor

(2015) Hengli Yang et al.   BIOMATERIALS

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease

(2015) Zhentao Zhang et al.   Nature Communications

Appraisal of the effect of brain impregnation duration on neuronal staining and morphology in a modified Golgi–Cox method

(2014) Sareesh Naduvil Narayanan et al.   JOURNAL OF NEUROSCIENCE METHODS

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

(2014) Zhentao Zhang et al.   NATURE MEDICINE

Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment

(2014) Ze Liu et al.   Nature Communications

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides

(2011) Jingwei Li et al.   BIOMATERIALS

Concurrent blood–brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatment

(2011) Chien-Yu Ting et al.   BIOMATERIALS

Noninvasive and localized neuronal delivery using short ultrasonic pulses and microbubbles

(2011) J. J. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cystatin E/M suppresses legumain activity and invasion of human melanoma

(2010) Jon J Briggs et al.   BMC CANCER

Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles

(2009) Yang Liu et al.   BIOMATERIALS

Increased hippocampal neurogenesis in the progressive stage of Alzheimer's disease phenotype in an APP/PS1 double transgenic mouse model

(2009) Yingxin Yu et al.   HIPPOCAMPUS

Targeted Ultrasound-Mediated Delivery of Nanoparticles: On the Development of a New HIFU-Based Therapy and Imaging Device

(2009) R. Seip et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Neuroprotective Actions of PIKE-L by Inhibition of SET Proteolytic Degradation by Asparagine Endopeptidase

(2008) Zhixue Liu et al.   MOLECULAR CELL