Fn14 and TNFR2 as regulators of cytotoxic TNFR1 signaling

CD4+ T Cell Dysfunction in Severe COVID-19 Disease is TNFα/TNFRI-Dependent

(2022) Iulia Popescu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TNFR2 is critical for TNF-induced rheumatoid arthritis fibroblast-like synoviocyte inflammation

(2022) Takahito Suto et al.   RHEUMATOLOGY

A potential fate decision landscape of the TWEAK/Fn14 axis on stem and progenitor cells: a systematic review

(2022) Sijia Wang et al.   Stem Cell Research & Therapy

TNF ‐α‐dependent lung inflammation upregulates PD‐L1 in monocyte‐derived macrophages to contribute to lung tumorigenesis

(2022) Yue Wen et al.   FASEB JOURNAL

Targeting fibroblast growth factor (FGF)-inducible 14 (Fn14) for tumor therapy

(2022) Olena Zaitseva et al.   Frontiers in Pharmacology

Selective inhibition of soluble tumor necrosis factor signaling reduces abdominal aortic aneurysm progression

(2022) Silke Griepke et al.   Frontiers in Cardiovascular Medicine

The regulation of necroptosis by post-translational modifications

(2021) Yanxiang Meng et al.   CELL DEATH AND DIFFERENTIATION

Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition

(2021) Kevin Litchfield et al.   CELL

Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate

(2021) Joanna L. Fox et al.   Nature Communications

Regulation of Caspase-8 Activity at the Crossroads of Pro-Inflammation and Anti-Inflammation

(2021) Jun-Hyuk Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Membrane lymphotoxin-α2β is a novel tumor necrosis factor (TNF) receptor 2 (TNFR2) agonist

(2021) Kirstin Kucka et al.   Cell Death & Disease

TWEAK Signaling Pathway Blockade Slows Cyst Growth and Disease Progression in Autosomal Dominant Polycystic Kidney Disease

(2021) Adrian Cordido et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Dying cells fan the flames of inflammation

(2021) Kim Newton et al.   SCIENCE

New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8

(2020) Robin Schwarzer et al.   CURRENT OPINION IN CELL BIOLOGY

Multiple roles of caspase‐8 in cell death, inflammation, and innate immunity

(2020) Pontus Orning et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Emerging connectivity of programmed cell death pathways and its physiological implications

(2020) Sammy Bedoui et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases

(2020) Juliane Totzke et al.   Open Biology

Combining Nivolumab and Ipilimumab with Infliximab or Certolizumab in Patients with Advanced Melanoma: First Results of a Phase Ib Clinical Trial

(2020) Anne Montfort et al.   CLINICAL CANCER RESEARCH

Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling

(2019) Simone Füllsack et al.   Cell Death & Disease

Tumor necrosis factor receptor-2 (TNFR2): an overview of an emerging drug target

(2019) Juliane Medler et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling

(2019) Ken Katsuya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fn14 Participates in Neuropathic Pain Through NF-κB Pathway in Primary Sensory Neurons

(2019) Li-Na Huang et al.   MOLECULAR NEUROBIOLOGY

Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy

(2019) Elisabeth Perez-Ruiz et al.   NATURE

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

(2019) David W. Vredevoogd et al.   CELL

Keeping Cell Death in Check: Ubiquitylation-Dependent Control of TNFR1 and TLR Signaling

(2019) Laura Griewahn et al.   Frontiers in Cell and Developmental Biology

TRAF2 Controls Death Receptor-Induced Caspase-8 Processing and Facilitates Proinflammatory Signaling

(2019) Jennifer Kreckel et al.   Frontiers in Immunology

TNFR2 Signaling Enhances ILC2 Survival, Function, and Induction of Airway Hyperreactivity

(2019) Benjamin P. Hurrell et al.   Cell Reports

The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex

(2018) Miguel Mompeán et al.   CELL

TWEAK and RIPK1 mediate a second wave of cell death during AKI

(2018) Diego Martin-Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FN14 Blockade on Pulmonary Microvascular Endothelial Cells Improves the Outcome of Sepsis-Induced Acute Lung Injury

(2018) Yun Zou et al.   SHOCK

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

(2018) Daichao Xu et al.   CELL

Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death

(2018) Ricard Garcia-Carbonell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fn14 deficiency ameliorates psoriasis-like skin disease in a murine model

(2018) L. Peng et al.   Cell Death & Disease

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation

(2018) Elodie Lafont et al.   NATURE CELL BIOLOGY

RIP Kinases in Liver Cell Death, Inflammation and Cancer

(2018) Vangelis Kondylis et al.   TRENDS IN MOLECULAR MEDICINE

Soluble TNF-like weak inducer of apoptosis (TWEAK) enhances poly(I:C)-induced RIPK1-mediated necroptosis

(2018) Mohamed A. Anany et al.   Cell Death & Disease

Inhibitor of Apoptosis Protein-1 Regulates Tumor Necrosis Factor–Mediated Destruction of Intestinal Epithelial Cells

(2017) Thomas Grabinger et al.   GASTROENTEROLOGY

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death

(2017) Isabel Jaco et al.   MOLECULAR CELL

DR5-Cbl-b/c-Cbl-TRAF2 complex inhibits TRAIL-induced apoptosis by promoting TRAF2-mediated polyubiquitination of caspase-8 in gastric cancer cells

(2017) Ling Xu et al.   Molecular Oncology

p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection

(2017) Manoj B. Menon et al.   NATURE CELL BIOLOGY

MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death

(2017) Yves Dondelinger et al.   NATURE CELL BIOLOGY

Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes

(2017) Jingjing Zhu et al.   Nature Communications

TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma

(2017) Florie Bertrand et al.   Nature Communications

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis

(2017) Jiefei Geng et al.   Nature Communications

XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation

(2017) Kate E. Lawlor et al.   Cell Reports

Lipopolysaccharide Upregulated Intestinal Epithelial Cell Expression of Fn14 and Activation of Fn14 Signaling Amplify Intestinal TLR4-Mediated Inflammation

(2017) Xuefeng Qi et al.   Frontiers in Cellular and Infection Microbiology

Deubiquitination and Stabilization of PD-L1 by CSN5

(2016) Seung-Oe Lim et al.   CANCER CELL

Protective Role for TWEAK/Fn14 in Regulating Acute Intestinal Inflammation and Colitis-Associated Tumorigenesis

(2016) Luca Di Martino et al.   CANCER RESEARCH

Poly-ubiquitination in TNFR1-mediated necroptosis

(2016) Yves Dondelinger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cell death-independent activities of the death receptors CD95, TRAILR1, and TRAILR2

(2016) Daniela Siegmund et al.   FEBS Journal

TRAF2 functions as an activator switch in the reactive oxygen species-induced stimulation of MST1

(2016) Kyung-Hye Roh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Interaction of TWEAK with Fn14 leads to the progression of fibrotic liver disease by directly modulating hepatic stellate cell proliferation

(2016) Annika Wilhelm et al.   JOURNAL OF PATHOLOGY

Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex

(2016) Tian-Min Fu et al.   MOLECULAR CELL

Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis

(2016) Daniela Siegmund et al.   Cell Death & Disease

Role of Fn14 in acute alcoholic steatohepatitis in mice

(2015) Gamze Karaca et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GVHD

(2015) M. Chopra et al.   BLOOD

TRAF2 is a biologically important necroptosis suppressor

(2015) S L Petersen et al.   CELL DEATH AND DIFFERENTIATION

TRAIL activates JNK and NF-κB through RIP1-dependent and -independent pathways

(2015) Laiqun Zhang et al.   CELLULAR SIGNALLING

TNF-like weak inducer of apoptosis promotes blood brain barrier disruption and increases neuronal cell death in MRL/lpr mice

(2015) Jing Wen et al.   JOURNAL OF AUTOIMMUNITY

Regulation of Coronary Endothelial Function by Interactions between TNF-α, LOX-1 and Adiponectin in Apolipoprotein E Knockout Mice

(2015) Xiuping Chen et al.   JOURNAL OF VASCULAR RESEARCH

Loss of ADAM17-Mediated Tumor Necrosis Factor Alpha Signaling in Intestinal Cells Attenuates Mucosal Atrophy in a Mouse Model of Parenteral Nutrition

(2015) Yongjia Feng et al.   MOLECULAR AND CELLULAR BIOLOGY

NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling

(2015) Yves Dondelinger et al.   MOLECULAR CELL

LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes

(2015) Peter Draber et al.   Cell Reports

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

(2015) Nima Etemadi et al.   eLife

Neuropathic pain-induced depressive-like behavior and hippocampal neurogenesis and plasticity are dependent on TNFR1 signaling

(2014) Anna Dellarole et al.   BRAIN BEHAVIOR AND IMMUNITY

Old, new and emerging functions of caspases

(2014) S Shalini et al.   CELL DEATH AND DIFFERENTIATION

Pathological activation of canonical nuclear-factor κB by synergy of tumor necrosis factor α and TNF-like weak inducer of apoptosis in mouse acute colitis

(2014) Taeko Dohi et al.   CYTOKINE

Genetic deletion or TWEAK blocking antibody administration reduce atherosclerosis and enhance plaque stability in mice

(2014) Cristina Sastre et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Soluble, but Not Transmembrane, TNF-  Is Required during Influenza Infection To Limit the Magnitude of Immune Responses and the Extent of Immunopathology

(2014) M. P. DeBerge et al.   JOURNAL OF IMMUNOLOGY

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

(2014) Nozomi Takahashi et al.   NATURE

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

(2014) Marius Dannappel et al.   NATURE

TRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis

(2014) I Karl et al.   Cell Death & Disease

Tumor Necrosis Factor‐Like Weak Inducer of Apoptosis or Fn14 Deficiency Reduce Elastase Perfusion‐Induced Aortic Abdominal Aneurysm in Mice

(2014) Carlos Tarín et al.   Journal of the American Heart Association

Deletion of Fn14 receptor protects from right heart fibrosis and dysfunction

(2013) Tatyana Novoyatleva et al.   BASIC RESEARCH IN CARDIOLOGY

TNF-related weak inducer of apoptosis (TWEAK) promotes kidney fibrosis and Ras-dependent proliferation of cultured renal fibroblast

(2013) Alvaro C. Ucero et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The TWEAK-Fn14 system as a potential drug target

(2013) Harald Wajant   BRITISH JOURNAL OF PHARMACOLOGY

Blockade of tumour necrosis factor-α in experimental autoimmune encephalomyelitis reveals differential effects on the antigen-specific immune response and central nervous system histopathology

(2013) H. Batoulis et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

TWEAK/Fn14 axis is a positive regulator of cardiac hypertrophy

(2013) Tatyana Novoyatleva et al.   CYTOKINE

The renal injury and inflammation caused by ischemia–reperfusion are reduced by genetic inhibition of TNF-αR1: A comparison with infliximab treatment

(2013) Rosanna Di Paola et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tumor Necrosis Factor Receptor Signaling in Keratinocytes Triggers Interleukin-24-Dependent Psoriasis-like Skin Inflammation in Mice

(2013) Snehlata Kumari et al.   IMMUNITY

cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation

(2012) S McComb et al.   CELL DEATH AND DIFFERENTIATION

IAPs limit activation of RIP kinases by TNF receptor 1 during development

(2012) Maryline Moulin et al.   EMBO JOURNAL

Aberrant accumulation of interleukin-10-secreting neutrophils in TRAF2-deficient mice

(2012) Jiang-Hu Piao et al.   IMMUNOLOGY AND CELL BIOLOGY

TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer

(2012) Francois Gonzalvez et al.   MOLECULAR CELL

c-FLIP Maintains Tissue Homeostasis by Preventing Apoptosis and Programmed Necrosis

(2012) X. Piao et al.   Science Signaling

Cellular Inhibitors of Apoptosis Are Global Regulators of NF- B and MAPK Activation by Members of the TNF Family of Receptors

(2012) E. Varfolomeev et al.   Science Signaling

Interleukin-13 Damages Intestinal Mucosa via TWEAK and Fn14 in Mice—A Pathway Associated With Ulcerative Colitis

(2011) Rei Kawashima et al.   GASTROENTEROLOGY

TWEAK/Fn14 pathway: an immunological switch for shaping tissue responses

(2011) Linda C. Burkly et al.   IMMUNOLOGICAL REVIEWS

Tumor Necrosis Factor Receptor-associated Factor (TRAF) 2 Controls Homeostasis of the Colon to Prevent Spontaneous Development of Murine Inflammatory Bowel Disease

(2011) Jiang-Hu Piao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology

(2011) M. Roulis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted tumor necrosis factor receptor I preligand assembly domain improves skin lesions in MRL/lpr mice

(2010) Guo-Min Deng et al.   ARTHRITIS AND RHEUMATISM

Extreme lymphoproliferative disease and fatal autoimmune thrombocytopenia in FasL and TRAIL double-deficient mice

(2010) L. M. Sedger et al.   BLOOD

Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation

(2010) M Won et al.   CELL DEATH AND DIFFERENTIATION

TNFR1 delivers pro-survival signals that are required for limiting TNFR2-dependent activation-induced cell death (AICD) in CD8+ T cells

(2010) Yuh-Ching Twu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Full-length, Membrane-anchored TWEAK Can Function as a Juxtacrine Signaling Molecule and Activate the NF-κB Pathway

(2010) Sharron A. N. Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble and Transmembrane TNF-Like Weak Inducer of Apoptosis Differentially Activate the Classical and Noncanonical NF- B Pathway

(2010) C. Roos et al.   JOURNAL OF IMMUNOLOGY

Lupus Serum IgG Induces Skin Inflammation through the TNFR1 Signaling Pathway

(2010) G.-M. Deng et al.   JOURNAL OF IMMUNOLOGY

Direct targeting of fibroblast growth factor-inducible 14 protein protects against renal ischemia reperfusion injury

(2010) Kiyohiko Hotta et al.   KIDNEY INTERNATIONAL

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

Tumor Necrosis Factor–Like Weak Inducer of Apoptosis (TWEAK) Enhances Vascular and Renal Damage Induced by Hyperlipidemic Diet in ApoE-Knockout Mice

(2009) Begoña Muñoz-García et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

(2009) Qian Yin et al.   BIOCHEMISTRY

TNF-like weak inducer of apoptosis inhibits proinflammatory TNF receptor-1 signaling

(2009) A Wicovsky et al.   CELL DEATH AND DIFFERENTIATION

Lack of TNFR2 expression by CD4+T cells exacerbates experimental colitis

(2009) Johanna Dayer Schneider et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Soluble TNF-α but not transmembrane TNF-α sensitizes T cells for enhanced activation-induced cell death

(2009) Stefan Müller et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis

(2009) James E. Vince et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Tumor Necrosis Factor (TNF) Induces p100 Processing via TNF Receptor-2 (TNFR2)

(2009) Hilka Rauert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blocking TNF-  Attenuates Aneurysm Formation in a Murine Model

(2009) W. Xiong et al.   JOURNAL OF IMMUNOLOGY

TNFR2-Deficient Memory CD8 T Cells Provide Superior Protection against Tumor Cell Growth

(2009) E. Y. Kim et al.   JOURNAL OF IMMUNOLOGY

Effect of T cells on vascular permeability in early ischemic acute kidney injury in mice

(2009) Manchang Liu et al.   MICROVASCULAR RESEARCH

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

(2009) Tobias L. Haas et al.   MOLECULAR CELL

Riboflavin kinase couples TNF receptor 1 to NADPH oxidase

(2009) Benjamin Yazdanpanah et al.   NATURE

Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1–TNFR2 cooperation

(2009) A Wicovsky et al.   ONCOGENE

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

TWEAK/Fn14 Pathway: A Nonredundant Role in Intestinal Damage in Mice Through a TWEAK/Intestinal Epithelial Cell Axis

(2008) Taeko Dohi et al.   GASTROENTEROLOGY

Blocking TNF-α in mice reduces colorectal carcinogenesis associated with chronic colitis

(2008) Boryana K. Popivanova et al.   JOURNAL OF CLINICAL INVESTIGATION

TL1A Both Promotes and Protects from Renal Inflammation and Injury

(2008) R. S. Al-Lamki et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Cytokine TWEAK Modulates Renal Tubulointerstitial Inflammation

(2008) A. B. Sanz et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

(2008) Sivakumar Vallabhapurapu et al.   NATURE IMMUNOLOGY

Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

(2008) Brian J Zarnegar et al.   NATURE IMMUNOLOGY

A tumor necrosis factor-α–mediated pathway promoting autosomal dominant polycystic kidney disease

(2008) Xiaogang Li et al.   NATURE MEDICINE

The TWEAK–Fn14 cytokine–receptor axis: discovery, biology and therapeutic targeting

(2008) Jeffrey A. Winkles   NATURE REVIEWS DRUG DISCOVERY

Both cIAP1 and cIAP2 regulate TNF -mediated NF- B activation

(2008) D. J. Mahoney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA