Structural analysis of human KDM5B guides histone demethylase inhibitor development

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives

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Structural definitions of Jumonji family demethylase selectivity

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Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases

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Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism

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Human UTY(KDM6C) Is a Male-specificNϵ-Methyl Lysyl Demethylase

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Inhibition of demethylases by GSK-J1/J4

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The KDM5 family of histone demethylases as targets in oncology drug discovery

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The roles of Jumonji-type oxygenases in human disease

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The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B

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Decision making inxia2

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Identification of Small Molecule Inhibitors of Jumonji AT-rich Interactive Domain 1B (JARID1B) Histone Demethylase by a Sensitive High Throughput Screen

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Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases

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Mechanisms of human histone and nucleic acid demethylases

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Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

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A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

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An integrated encyclopedia of DNA elements in the human genome

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Complexities of occupancy and sequence

(2012) Mary Muers   NATURE REVIEWS GENETICS

Inhibition of Histone Demethylases by 4-Carboxy-2,2′-Bipyridyl Compounds

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Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family

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Integration, scaling, space-group assignment and post-refinement

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

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Structural studies on human 2-oxoglutarate dependent oxygenases

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Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

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The art of the chemical probe

(2010) Stephen V Frye   Nature Chemical Biology

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

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A miniaturized screen for inhibitors of Jumonji histone demethylases

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Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

(2009) John R Horton et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

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Dynamic protein methylation in chromatin biology

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Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2

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Model-based Analysis of ChIP-Seq (MACS)

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