Human in vitro modeling of adjuvant formulations demonstrates enhancement of immune responses to SARS-CoV-2 antigen

An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice

(2022) Etsuro Nanishi et al.   Science Translational Medicine

Precision Vaccine Development: Cues From Natural Immunity

(2022) Soumik Barman et al.   Frontiers in Immunology

Competing responses to global inequalities in access to COVID vaccines: Vaccine Diplomacy and Vaccine Charity Versus Vaccine Liberty

(2022) Matthew Sparke et al.   CLINICAL INFECTIOUS DISEASES

IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines

(2022) Siri Tahtinen et al.   NATURE IMMUNOLOGY

CAF08 adjuvant enables single dose protection against respiratory syncytial virus infection in murine newborns

(2022) Simon D. van Haren et al.   Nature Communications

mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant

(2022) Etsuro Nanishi et al.   Communications Biology

Emerging concepts in the science of vaccine adjuvants

(2021) Bali Pulendran et al.   NATURE REVIEWS DRUG DISCOVERY

dmLT Adjuvant Enhances Cytokine Responses to T Cell Stimuli, Whole Cell Vaccine Antigens and Lipopolysaccharide in Both Adults and Infants

(2021) Marjahan Akhtar et al.   Frontiers in Immunology

Decolonising human rights: how intellectual property laws result in unequal access to the COVID-19 vaccine

(2021) Sharifah Sekalala et al.   BMJ Global Health

Economic Consequences of the COVID-19 Outbreak: the Need for Epidemic Preparedness

(2020) Anton Pak et al.   Frontiers in Public Health

Identification of potential biomarkers of vaccine inflammation in mice

(2019) Paul F McKay et al.   eLife

The how’s and what’s of vaccine reactogenicity

(2019) Caroline Hervé et al.   npj Vaccines

Identification of T helper (Th)1- and Th2-associated antigens of Cryptococcus neoformans in a murine model of pulmonary infection

(2018) Carolina Firacative et al.   Scientific Reports

The Mucosal Vaccine Adjuvant LT(R192G/L211A) or dmLT

(2018) John D. Clements et al.   mSphere

Microphysiologic Human Tissue Constructs Reproduce Autologous Age-Specific BCG and HBV Primary Immunization in vitro

(2018) Guzman Sanchez-Schmitz et al.   Frontiers in Immunology

Lysosome-Dependent Activation of Human Dendritic Cells by the Vaccine Adjuvant QS-21

(2017) Iain Welsby et al.   Frontiers in Immunology

Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity

(2017) Margherita Coccia et al.   npj Vaccines

In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant

(2016) Simon D. van Haren et al.   CYTOKINE

Adjuvant system AS01: helping to overcome the challenges of modern vaccines

(2016) Arnaud M. Didierlaurent et al.   Expert Review of Vaccines

Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization

(2016) Simon D. van Haren et al.   JOURNAL OF IMMUNOLOGY

Cholera Toxin, and the Related Nontoxic Adjuvants mmCT and dmLT, Promote Human Th17 Responses via Cyclic AMP–Protein Kinase A and Inflammasome-Dependent IL-1 Signaling

(2015) Maximilian Larena et al.   JOURNAL OF IMMUNOLOGY

Enhancement of Adaptive Immunity by the Human Vaccine Adjuvant AS01 Depends on Activated Dendritic Cells

(2014) Arnaud M. Didierlaurent et al.   JOURNAL OF IMMUNOLOGY

Ontogeny of early life immunity

(2014) David J. Dowling et al.   TRENDS IN IMMUNOLOGY

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1–dependent pathways

(2012) Victoria J. Philbin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Adjuvant Double Mutant Escherichia coli Heat Labile Toxin Enhances IL-17A Production in Human T Cells Specific for Bacterial Vaccine Antigens

(2012) Susannah Leach et al.   PLoS One

Cell-mediated immune responses to a varicella-zoster virus glycoprotein E vaccine using both a TLR agonist and QS21 in mice

(2012) Najoua Dendouga et al.   VACCINE

Recent clinical experience with vaccines using MPL- and QS-21-containing Adjuvant Systems

(2011) Nathalie Garçon et al.   Expert Review of Vaccines

Neonatal Innate TLR-Mediated Responses Are Distinct from Those of Adults

(2009) T. R. Kollmann et al.   JOURNAL OF IMMUNOLOGY