The Mucosal Vaccine Adjuvant LT(R192G/L211A) or dmLT

Preformulation studies with the Escherichia coli double mutant heat-labile toxin adjuvant for use in an oral vaccine

(2017) Jessica A. White et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Adjuvant selection regulates gut migration and phenotypic diversity of antigen-specific CD4+ T cells following parenteral immunization

(2017) D R Frederick et al.   Mucosal Immunology

Immunization with Salmonella Enteritidis secreting mucosal adjuvant labile toxin confers protection against wild type challenge via augmentation of CD3 + CD4 + T-cell proliferation and enhancement of IFN-γ, IL-6 and IL-10 expressions in chicken

(2017) Jonathan Lalsiamthara et al.   VACCINE

Development of a candidate stabilizing formulation for bulk storage of a double mutant heat labile toxin (dmLT) protein based adjuvant

(2017) Vishal M. Toprani et al.   VACCINE

Silk Fibroin Microneedles for Transdermal Vaccine Delivery

(2017) Jordan A. Stinson et al.   ACS Biomaterials-Science & Engineering

Silk Fibroin Microneedles for Transdermal Vaccine Delivery

(2017) Jordan A. Stinson et al.   ACS Biomaterials Science & Engineering

Immunogenicity and Protective Efficacy against Enterotoxigenic Escherichia coli Colonization following Intradermal, Sublingual, or Oral Vaccination with EtpA Adhesin

(2016) Qingwei Luo et al.   Clinical and Vaccine Immunology

Highlights of the 8th International Conference on Vaccines for Enteric Diseases: the Scottish Encounter To Defeat Diarrheal Diseases

(2016) Sharon M. Tennant et al.   Clinical and Vaccine Immunology

Induction of mucosal immune responses againstHelicobacter pyloriinfection after sublingual and intragastric route of immunization

(2016) Louise Sjökvist Ottsjö et al.   IMMUNOLOGY

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity

(2015) Denise Morais da Fonseca et al.   CELL

Shigella Outer Membrane Protein PSSP-1 Is Broadly Protective against Shigella Infection

(2015) Jae-Ouk Kim et al.   Clinical and Vaccine Immunology

Therapeutic Transcutaneous Immunization with a Band-Aid Vaccine Resolves Experimental Otitis Media

(2015) Laura A. Novotny et al.   Clinical and Vaccine Immunology

Cholera Toxin, and the Related Nontoxic Adjuvants mmCT and dmLT, Promote Human Th17 Responses via Cyclic AMP–Protein Kinase A and Inflammasome-Dependent IL-1 Signaling

(2015) Maximilian Larena et al.   JOURNAL OF IMMUNOLOGY

Conformational instability governed by disulfide bonds partitions the dominant from subdominant helper T-cell responses specific for HIV-1 envelope glycoprotein gp120

(2015) Hong-Nam P. Nguyen et al.   VACCINE

The novel adjuvant dmLT promotes dose sparing, mucosal immunity and longevity of antibody responses to the inactivated polio vaccine in a murine model

(2015) Elizabeth B. Norton et al.   VACCINE

Genetic Fusions of a CFA/I/II/IV MEFA (Multiepitope Fusion Antigen) and a Toxoid Fusion of Heat-Stable Toxin (STa) and Heat-Labile Toxin (LT) of Enterotoxigenic Escherichia coli (ETEC) Retain Broad Anti-CFA and Antitoxin Antigenicity

(2015) Xiaosai Ruan et al.   PLoS One

Evaluating the A-Subunit of the Heat-Labile Toxin (LT) As an Immunogen and a Protective Antigen Against Enterotoxigenic Escherichia coli (ETEC)

(2015) Elizabeth B. Norton et al.   PLoS One

Immunization with a Double-Mutant (R192G/L211A) of the Heat-Labile Enterotoxin of Escherichia coli Offers Partial Protection against Campylobacter jejuni in an Adult Mouse Intestinal Colonization Model

(2015) M. John Albert et al.   PLoS One

Development and Preclinical Evaluation of a Trivalent, Formalin-Inactivated Shigella Whole-Cell Vaccine

(2014) R. W. Kaminski et al.   Clinical and Vaccine Immunology

Intradermal Delivery of Shigella IpaB and IpaD Type III Secretion Proteins: Kinetics of Cell Recruitment and Antigen Uptake, Mucosal and Systemic Immunity, and Protection across Serotypes

(2014) S. J. Heine et al.   JOURNAL OF IMMUNOLOGY

The immune response of two microbial antigens delivered intradermally, sublingually, or the combination thereof

(2014) Sangun Lee et al.   MICROBES AND INFECTION

Safety and immunogenicity of an improved oral inactivated multivalent enterotoxigenic Escherichia coli (ETEC) vaccine administered alone and together with dmLT adjuvant in a double-blind, randomized, placebo-controlled Phase I study

(2014) Anna Lundgren et al.   VACCINE

Serum and mucosal antibody responses to inactivated polio vaccine after sublingual immunization using a thermoresponsive gel delivery system

(2014) Jessica A White et al.   Human Vaccines & Immunotherapeutics

Evaluation in Mice of a Conjugate Vaccine for Cholera Made from Vibrio cholerae O1 (Ogawa) O-Specific Polysaccharide

(2014) Mohammad Murshid Alam et al.   PLoS Neglected Tropical Diseases

Safety and Immunogenicity of a Single Oral Dose of Recombinant Double Mutant Heat-Labile Toxin Derived from Enterotoxigenic Escherichia coli

(2013) Samer S. El-Kamary et al.   Clinical and Vaccine Immunology

A Double Mutant Heat-Labile Toxin from Escherichia coli, LT(R192G/L211A), Is an Effective Mucosal Adjuvant for Vaccination against Helicobacter pylori Infection

(2013) Louise Sjökvist Ottsjö et al.   INFECTION AND IMMUNITY

Development and preclinical evaluation of safety and immunogenicity of an oral ETEC vaccine containing inactivated E. coli bacteria overexpressing colonization factors CFA/I, CS3, CS5 and CS6 combined with a hybrid LT/CT B subunit antigen, administered alone and together with dmLT adjuvant

(2013) J. Holmgren et al.   VACCINE

The A Subunit of Escherichia coli Heat-Labile Enterotoxin Functions as a Mucosal Adjuvant and Promotes IgG2a, IgA, and Th17 Responses to Vaccine Antigens

(2012) Elizabeth B. Norton et al.   INFECTION AND IMMUNITY

The Adjuvant Double Mutant Escherichia coli Heat Labile Toxin Enhances IL-17A Production in Human T Cells Specific for Bacterial Vaccine Antigens

(2012) Susannah Leach et al.   PLoS One

Bioencapsulation of the hepatitis B surface antigen and its use as an effective oral immunogen

(2012) Celine A. Hayden et al.   VACCINE

A randomized control trial comparing immunogenicity, safety, and preference for self- versus nurse-administered intradermal influenza vaccine

(2012) Brenda L. Coleman et al.   VACCINE

Kinetic analysis and evaluation of the mechanisms involved in the resolution of experimental nontypeable Haemophilus influenzae-induced otitis media after transcutaneous immunization

(2012) Laura A. Novotny et al.   VACCINE

Characterization of a Mutant Escherichia coli Heat-Labile Toxin, LT(R192G/L211A), as a Safe and Effective Oral Adjuvant

(2011) Elizabeth B. Norton et al.   Clinical and Vaccine Immunology

Defending the mucosa: adjuvant and carrier formulations for mucosal immunity

(2011) Louise B Lawson et al.   CURRENT OPINION IN IMMUNOLOGY

Broadly Protective Shigella Vaccine Based on Type III Secretion Apparatus Proteins

(2011) Francisco J. Martinez-Becerra et al.   INFECTION AND IMMUNITY

Escherichia coli Heat-Labile Enterotoxin Promotes Protective Th17 Responses against Infection by Driving Innate IL-1 and IL-23 Production

(2011) C. F. Brereton et al.   JOURNAL OF IMMUNOLOGY

Transcutaneous immunization as preventative and therapeutic regimens to protect against experimental otitis media due to nontypeable Haemophilus influenzae

(2011) L A Novotny et al.   Mucosal Immunology

Development of a Bacillus subtilis-Based Rotavirus Vaccine

(2010) S. Lee et al.   Clinical and Vaccine Immunology

Options for Inactivation, Adjuvant, and Route of Topical Administration of a Killed, Unencapsulated Pneumococcal Whole-Cell Vaccine

(2010) Y.-J. Lu et al.   Clinical and Vaccine Immunology

Prophylactic Administration of Bacterially Derived Immunomodulators Improves the Outcome of Influenza Virus Infection in a Murine Model

(2010) E. B. Norton et al.   JOURNAL OF VIROLOGY

Proinflammatory T helper type 17 cells are effective B-cell helpers

(2010) M. Mitsdoerffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax

(2010) S. K. Datta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen-specific Treg regulate Th17-mediated lung neutrophilic inflammation, B-cell recruitment and polymeric IgA and IgM levels in the airways

(2009) Zeina Jaffar et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cholera Toxin and Escherichia coli Heat-Labile Enterotoxin, but Not Their Nontoxic Counterparts, Improve the Antigen-Presenting Cell Function of Human B Lymphocytes

(2009) D. R. M. Negri et al.   INFECTION AND IMMUNITY

Cutting Edge: Lung Mucosal Th17-Mediated Responses Induce Polymeric Ig Receptor Expression by the Airway Epithelium and Elevate Secretory IgA Levels

(2009) Z. Jaffar et al.   JOURNAL OF IMMUNOLOGY

CD11chigh Dendritic Cells Are Essential for Activation of CD4+ T Cells and Generation of Specific Antibodies following Mucosal Immunization

(2009) L. Fahlen-Yrlid et al.   JOURNAL OF IMMUNOLOGY

Kinetics of Immune Responses to Influenza Virus-Like Particles and Dose-Dependence of Protection with a Single Vaccination

(2009) F. S. Quan et al.   JOURNAL OF VIROLOGY

Interleukin 17 acts in synergy with B cell–activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus

(2009) Agnès Doreau et al.   NATURE IMMUNOLOGY

Intranasal Delivery of Cholera Toxin Induces Th17-Dominated T-Cell Response to Bystander Antigens

(2009) Jee-Boong Lee et al.   PLoS One

Transient Facial Nerve Paralysis (Bell's Palsy) following Intranasal Delivery of a Genetically Detoxified Mutant of Escherichia coli Heat Labile Toxin

(2009) David J. M. Lewis et al.   PLoS One

Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages

(2009) A. L. Hertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toward the development of a stable, freeze-dried formulation of Helicobacter pylori killed whole cell vaccine adjuvanted with a novel mutant of Escherichia coli heat-labile toxin

(2009) Nancy A. Summerton et al.   VACCINE