Obesity alters pathology and treatment response in inflammatory disease

Dupilumab improves upper- and lower-airway disease control in chronic rhinosinusitis with nasal polyps and asthma

(2021) Tanya M. Laidlaw et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Mixed Sputum Granulocyte Longitudinal Impact on Lung Function in the Severe Asthma Research Program

(2021) Annette T Hastie et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Baseline sputum eosinophil+neutrophil subgroups’ clinical characteristics and longitudinal trajectories for NHLBI Severe Asthma Research Program (SARP 3) Cohort

(2020) A.T. Hastie et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Longitudinal analyses reveal immunological misfiring in severe COVID-19

(2020) Carolina Lucas et al.   NATURE

Generalizing RNA velocity to transient cell states through dynamical modeling

(2020) Volker Bergen et al.   NATURE BIOTECHNOLOGY

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

(2020) Alison E. Ringel et al.   CELL

Therapeutic targeting of the IL-13 pathway in skin inflammation

(2020) Carla Tubau et al.   Expert Review of Clinical Immunology

Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation

(2019) Johan Henriksson et al.   CELL

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes

(2019) Dequina A. Nicholas et al.   Cell Metabolism

The Metabolic Requirements of Th2 Cell Differentiation

(2019) Julian M. Stark et al.   Frontiers in Immunology

STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth

(2019) Chunyan Zhang et al.   Cell Metabolism

Unraveling the Complex Interplay Between T Cell Metabolism and Function

(2018) Ramon I. Klein Geltink et al.   Annual Review of Immunology

Dupilumab: A review of its use in the treatment of atopic dermatitis

(2018) Melinda J. Gooderham et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

The burden of atopic dermatitis in US adults: Health care resource utilization data from the 2013 National Health and Wellness Survey

(2018) Laurent Eckert et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Understanding Asthma Phenotypes, Endotypes, and Mechanisms of Disease

(2018) Merin E. Kuruvilla et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

RNA velocity of single cells

(2018) Gioele La Manno et al.   NATURE

Dimensionality reduction for visualizing single-cell data using UMAP

(2018) Etienne Becht et al.   NATURE BIOTECHNOLOGY

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses

(2018) Xavier Michelet et al.   NATURE IMMUNOLOGY

Maturing of the nuclear receptor family

(2017) Mitchell A. Lazar   JOURNAL OF CLINICAL INVESTIGATION

PPARγ in dendritic cells and T cells drives pathogenic type-2 effector responses in lung inflammation

(2017) Samuel Philip Nobs et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults

(2017) Leandra Abarca-Gómez et al.   LANCET

Health Effects of Overweight and Obesity in 195 Countries over 25 Years

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants

(2016)   LANCET

Association of atopic dermatitis with being overweight and obese: A systematic review and metaanalysis

(2015) April Zhang et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Depletion of fat-resident Treg cells prevents age-associated insulin resistance

(2015) Sagar P. Bapat et al.   NATURE

Obesity Drives Th17 Cell Differentiation by Inducing the Lipid Metabolic Kinase, ACC1

(2015) Yusuke Endo et al.   Cell Reports

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade

(2013) Juan Manuel Leyva-Castillo et al.   Nature Communications

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

(2012) Han Cho et al.   NATURE

Differential analysis of gene regulation at transcript resolution with RNA-seq

(2012) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Asthma phenotypes: the evolution from clinical to molecular approaches

(2012) Sally E Wenzel   NATURE MEDICINE

Heterogeneity of Inflammatory and Cytokine Networks in Chronic Plaque Psoriasis

(2012) William R. Swindell et al.   PLoS One

Identification of novel transcripts in annotated genomes using RNA-Seq

(2011) A. Roberts et al.   BIOINFORMATICS

Integrative Responses to IL-17 and TNF-α in Human Keratinocytes Account for Key Inflammatory Pathogenic Circuits in Psoriasis

(2010) Andrea Chiricozzi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Obesity predisposes to Th17 bias

(2009) Shawn Winer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell–intrinsic fashion and suppresses CNS autoimmunity

(2009) Luisa Klotz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

(2008) Yuri P. Rubtsov et al.   IMMUNITY

Atopic Dermatitis

(2008) Thomas Bieber   NEW ENGLAND JOURNAL OF MEDICINE

Differentiation of regulatory Foxp3+ T cells in the thymic cortex

(2008) A. Liston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA