Reperfusion and cytoprotective agents are a mutually beneficial pair in ischaemic stroke therapy: an overview of pathophysiology, pharmacological targets and candidate drugs focusing on excitotoxicity and free radical

Matrix Metalloproteinases in Cardioembolic Stroke: From Background to Complications

(2023) Anna Wysocka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

APRIL: A double-blind, placebo-controlled, randomized, Phase Ib/IIa clinical study of ApTOLL for the treatment of acute ischemic stroke

(2023) Macarena Hernández-Jiménez et al.   Frontiers in Neurology

Preclinical evaluation of ZL006-05, a new antistroke drug with fast-onset antidepressant and anxiolytic effects

(2023) Haiyin Wu et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Choline-Containing Phospholipids in Stroke Treatment: A Systematic Review and Meta-Analysis

(2023) Getu Gamo Sagaro et al.   Journal of Clinical Medicine

Rationale and design of ENDEAVOR: A sequential phase 2b–3 randomized clinical trial to evaluate the effect of myeloperoxidase inhibition on symptoms and exercise capacity in heart failure with preserved or mildly reduced ejection fraction

(2023) Lars H. Lund et al.   EUROPEAN JOURNAL OF HEART FAILURE

Mechanisms of inhibition and activation of extrasynaptic αβ GABAA receptors

(2022) Vikram Babu Kasaragod et al.   NATURE

Pharmacological brain cytoprotection in acute ischaemic stroke — renewed hope in the reperfusion era

(2022) Marc Fisher et al.   Nature Reviews Neurology

China Stroke Statistics: an update on the 2019 report from the National Center for Healthcare Quality Management in Neurological Diseases, China National Clinical Research Center for Neurological Diseases, the Chinese Stroke Association, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations

(2022) Yong-Jun Wang et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Nelonemdaz for Patients With Acute Ischemic Stroke Undergoing Endovascular Reperfusion Therapy: A Randomized Phase II Trial

(2022) Ji Man Hong et al.   STROKE

Arterial Glyceryl Trinitrate in Acute Ischemic Stroke after Thrombectomy for Neuroprotection (AGAIN): Rationale, design and protocol for a prospective randomized controlled trial

(2022) Jie Gao et al.   BMC Geriatrics

Therapeutic inhibition of MPO stabilizes pre-existing high risk atherosclerotic plaque

(2022) Weiyu Chen et al.   Redox Biology

Effect of Endovascular Treatment Alone vs Intravenous Alteplase Plus Endovascular Treatment on Functional Independence in Patients With Acute Ischemic Stroke

(2021) Wenjie Zi et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Relationship between the degree of recanalization and functional outcome in acute ischemic stroke is mediated by penumbra salvage volume

(2021) Gabriel Broocks et al.   JOURNAL OF NEUROLOGY

Pathophysiology and Therapeutic Potential of NADPH Oxidases in Ischemic Stroke-Induced Oxidative Stress

(2021) Jinnan Duan et al.   Oxidative Medicine and Cellular Longevity

Edaravone Dexborneol Versus Edaravone Alone for the Treatment of Acute Ischemic Stroke

(2021) Jie Xu et al.   STROKE

Platelets as drivers of ischemia/reperfusion injury after stroke

(2021) Noor F. Shaik et al.   Blood Advances

The Nrf2 Pathway in Ischemic Stroke: A Review

(2021) Marcelo Farina et al.   MOLECULES

Targeting Pro-Oxidant Iron with Deferoxamine as a Treatment for Ischemic Stroke: Safety and Optimal Dose Selection in a Randomized Clinical Trial

(2021) Mònica Millán et al.   Antioxidants

Stepwise disassembly of GABAergic synapses during pathogenic excitotoxicity

(2021) Joshua D. Garcia et al.   Cell Reports

Deletion of a neuronal Drp1 activator protects against cerebral ischemia

(2020) Kyle H. Flippo et al.   JOURNAL OF NEUROSCIENCE

Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial

(2020) Michael D Hill et al.   LANCET

Safety and efficacy of GABAA α5 antagonist S44819 in patients with ischaemic stroke: a multicentre, double-blind, randomised, placebo-controlled trial

(2020) Hugues Chabriat et al.   LANCET NEUROLOGY

Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke

(2020) Lijing Kang et al.   Nature Communications

Natalizumab in acute ischemic stroke (ACTION II): a randomized, placebo-controlled trial

(2020) Mitchell S. V. Elkind et al.   NEUROLOGY

Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies

(2020) Surojit Paul et al.   EXPERIMENTAL NEUROLOGY

Safety, tolerability, pharmacokinetics and effect on serum uric acid of the myeloperoxidase inhibitor AZD4831 in a randomized, placebo-controlled, phase 1 study in healthy volunteers

(2019) Li-Ming Gan et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

From single drug targets to synergistic network pharmacology in ischemic stroke

(2019) Ana I. Casas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global brain inflammation in stroke

(2019) Kaibin Shi et al.   LANCET NEUROLOGY

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

(2019) Natalia Robledinos-Antón et al.   Oxidative Medicine and Cellular Longevity

Reducing myeloperoxidase activity decreases inflammation and increases cellular protection in ischemic stroke

(2018) Hyeon J Kim et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Early Blood-Brain Barrier Disruption after Mechanical Thrombectomy in Acute Ischemic Stroke

(2018) Zhong-Song Shi et al.   JOURNAL OF NEUROIMAGING

Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activ

(2018) Patrick Lyden et al.   ANNALS OF NEUROLOGY

Potential molecular targets of peroxynitrite in mediating blood–brain barrier damage and haemorrhagic transformation in acute ischaemic stroke with delayed tissue plasminogen activator treatment

(2018) Hansen Chen et al.   FREE RADICAL RESEARCH

Imaging the physiological evolution of the ischemic penumbra in acute ischemic stroke

(2017) Richard Leigh et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão’s legacy

(2016) Jed A Hartings et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis

(2016) William N Whiteley et al.   LANCET NEUROLOGY

Unbalanced Metalloproteinase-9 and Tissue Inhibitors of Metalloproteinases Ratios Predict Hemorrhagic Transformation of Lesion in Ischemic Stroke Patients Treated with Thrombolysis: Results from the MAGIC Study

(2015) Benedetta Piccardi et al.   Frontiers in Neurology

Spreading depression triggers ictaform activity in partially disinhibited neuronal tissues

(2013) Marius Eickhoff et al.   EXPERIMENTAL NEUROLOGY

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

(2011) Uwe Rudolph et al.   NATURE REVIEWS DRUG DISCOVERY

The PSD-95/nNOS complex: New drugs for depression?

(2011) Marika V. Doucet et al.   PHARMACOLOGY & THERAPEUTICS

Spreading Depression and Related Events Are Significant Sources of Neuronal Zn2+ Release and Accumulation

(2010) Russell E Carter et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95

(2010) Li Zhou et al.   NATURE MEDICINE

Preservation of GABA A Receptor Function by PTEN Inhibition Protects Against Neuronal Death in Ischemic Stroke

(2010) Baosong Liu et al.   STROKE

Spreading depolarizations occur in human ischemic stroke with high incidence

(2008) Christian Dohmen et al.   ANNALS OF NEUROLOGY

Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase

(2008) M. O. Breckwoldt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Excitation control: balancing PSD-95 function at the synapse

(2008) Dove Keith   Frontiers in Molecular Neuroscience