Targeting Pro-Oxidant Iron with Deferoxamine as a Treatment for Ischemic Stroke: Safety and Optimal Dose Selection in a Randomized Clinical Trial

Safety and Efficacy of Sovateltide (IRL-1620) in a Multicenter Randomized Controlled Clinical Trial in Patients with Acute Cerebral Ischemic Stroke

(2021) Anil Gulati et al.   CNS DRUGS

Acute ischemic stroke & emergency mechanical thrombectomy: The effect of type of anesthesia on early outcome

(2021) Vinay Byrappa et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Effects of dietary polyphenol supplementation on iron status and erythropoiesis: a systematic review and meta-analysis of randomized controlled trials

(2021) Teng Xu et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Ferroptosis and traumatic brain injury

(2021) Zhiwen Geng et al.   BRAIN RESEARCH BULLETIN

Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases

(2021) Qingyun Tan et al.   Frontiers in Pharmacology

Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats

(2020) Bin Lan et al.   Journal of Integrative Medicine-JIM

Deferoxamine Treatment Prevents Post-Stroke Vasoregression and Neurovascular Unit Remodeling Leading to Improved Functional Outcomes in Type 2 Male Diabetic Rats: Role of Endothelial Ferroptosis

(2020) Yasir Abdul et al.   Translational Stroke Research

Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model

(2020) Wei Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Deciphering the Iron Side of Stroke: Neurodegeneration at the Crossroads Between Iron Dyshomeostasis, Excitotoxicity, and Ferroptosis

(2019) Núria DeGregorio-Rocasolano et al.   Frontiers in Neuroscience

Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial

(2019) Magdy Selim et al.   LANCET NEUROLOGY

Ferroptosis and Brain Injury

(2019) Leslie Magtanong et al.   DEVELOPMENTAL NEUROSCIENCE

Deferoxamine Alleviates Iron Overload and Brain Injury in a Rat Model of Brainstem Hemorrhage

(2019) Xi Guo et al.   World Neurosurgery

Inhibition of neuronal ferroptosis in the acute phase of intracerebral hemorrhage shows long-term cerebroprotective effects

(2019) Bin Chen et al.   BRAIN RESEARCH BULLETIN

Iron-chelating agents attenuate NMDA-Induced neuronal injury via reduction of oxidative stress in the rat retina

(2018) Kenji Sakamoto et al.   EXPERIMENTAL EYE RESEARCH

Nanogel-DFO conjugates as a model to investigate pharmacokinetics, biodistribution, and iron chelation in vivo

(2018) Yan Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Iron Overload Exacerbates the Risk of Hemorrhagic Transformation After tPA (Tissue-Type Plasminogen Activator) Administration in Thromboembolic Stroke Mice

(2018) Isaac García-Yébenes et al.   STROKE

High-Dose Deferoxamine Treatment Disrupts Intracellular Iron Homeostasis, Reduces Growth, and Induces Apoptosis in Metastatic and Nonmetastatic Breast Cancer Cell Lines

(2018) Khuloud Bajbouj et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage

(2018) Nuria DeGregorio-Rocasolano et al.   Redox Biology

N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice

(2018) Saravanan S. Karuppagounder et al.   ANNALS OF NEUROLOGY

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

Chelation in metal intoxication—Principles and paradigms

(2015) Jan Aaseth et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Efficacy of Deferoxamine in Animal Models of Intracerebral Hemorrhage: A Systematic Review and Stratified Meta-Analysis

(2015) Han-Jin Cui et al.   PLoS One

The Clinical Effect of Deferoxamine Mesylate on Edema after Intracerebral Hemorrhage

(2015) Yao Yu et al.   PLoS One

High Dose Deferoxamine in Intracerebral Hemorrhage (Hi-Def) Trial: Rationale, Design, and Methods

(2013) Sharon D. Yeatts et al.   Neurocritical Care

Role of the NMDA receptor and iron on free radical production and brain damage following transient middle cerebral artery occlusion

(2012) Doo Soon Im et al.   BRAIN RESEARCH

Prophylactic neuroprotection against stroke: Low-dose, prolonged treatment with deferoxamine or deferasirox establishes prolonged neuroprotection independent of HIF-1 function

(2011) Yanxin Zhao et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Safety and Tolerability of Deferoxamine Mesylate in Patients With Acute Intracerebral Hemorrhage

(2011) Magdy Selim et al.   STROKE

Iron-Related Brain Damage in Patients With Intracerebral Hemorrhage

(2010) Natalia Pérez de la Ossa et al.   STROKE

Effects of deferoxamine on brain injury after transient focal cerebral ischemia in rats with hyperglycemia

(2009) Yingqi Xing et al.   BRAIN RESEARCH

Intranasal Deferoxamine Provides Increased Brain Exposure and Significant Protection in Rat Ischemic Stroke

(2009) L. R. Hanson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Association Between Serum Ferritin Level and Perihematoma Edema Volume in Patients With Spontaneous Intracerebral Hemorrhage

(2008) Manu Mehdiratta et al.   STROKE

Desferoxamine preconditioning protects against cerebral ischemia in rats by inducing expressions of hypoxia inducible factor 1α and erythropoietin

(2008) Yun-Xia Li et al.   Neuroscience Bulletin