Exosomal miR-129 and miR-342 derived from intermittent hypoxia-stimulated vascular smooth muscle cells inhibit the eIF2α/ATF4 axis from preventing calcified aortic valvular disease

Origin of translational control by eIF2α phosphorylation: insights from genome-wide translational profiling studies in fission yeast

(2021) Katsura Asano   CURRENT GENETICS

Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling

(2021) Uddalak Majumdar et al.   Science Advances

Clinical significance of the long non‑coding RNA NEAT1/miR‑129‑5p axis in the diagnosis and prognosis for patients with chronic heart failure

(2021) Haohua Zhang et al.   Experimental and Therapeutic Medicine

The ameliorative effect of terpinen-4-ol on ER stress-induced vascular calcification depends on SIRT1-mediated regulation of PERK acetylation

(2021) Yanyan Zhang et al.   PHARMACOLOGICAL RESEARCH

Ameliorative effect of allicin on vascular calcification via inhibiting endoplasmic reticulum stress

(2021) Qin Wang et al.   Vascular

Melatonin alleviates vascular calcification and ageing through exosomal miR‐204/miR‐211 cluster in a paracrine manner

(2020) Feng Xu et al.   JOURNAL OF PINEAL RESEARCH

Vascular Smooth Muscle Cell-Derived Exosomal MicroRNAs Regulate Endothelial Cell Migration Under PDGF Stimulation

(2020) Jeongyeon Heo et al.   Cells

Aortic Valve Stenosis

(2020) Philip Roger Goody et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

(2020) Peng Huang et al.   BLOOD

Rosuvastatin protects against endothelial cell apoptosis in vitro and alleviates atherosclerosis in ApoE‑/‑ mice by suppressing endoplasmic reticulum stress

(2020) Jianan Geng et al.   Experimental and Therapeutic Medicine

miR-214 attenuates aortic valve calcification by regulating osteogenic differentiation of valvular interstitial cells

(2020) Ning Li et al.   Molecular Therapy-Nucleic Acids

Intercepting the Lipid-Induced Integrated Stress Response Reduces Atherosclerosis

(2019) Umut I. Onat et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Exosomes derived from mesenchymal stem cells attenuate the progression of atherosclerosis in ApoE−/- mice via miR-let7 mediated infiltration and polarization of M2 macrophage

(2019) Jiangbing Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adaptive Immune Cells in Calcific Aortic Valve Disease

(2019) Michael A Raddatz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Hypoxia Triggers Osteochondrogenic Differentiation of Vascular Smooth Muscle Cells in an HIF-1 (Hypoxia-Inducible Factor 1)–Dependent and Reactive Oxygen Species–Dependent Manner

(2019) Enikő Balogh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Proliferative Pathways of Vascular Smooth Muscle Cells in Response to Intermittent Hypoxia

(2019) Yoji Kyotani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

miR-129-5p improves cardiac function in rats with chronic heart failure through targeting HMGB1

(2019) Na Xiao et al.   MAMMALIAN GENOME

Differentially expressed microRNA profiles in exosomes from vascular smooth muscle cells associated with coronary artery calcification

(2019) Wei Pan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Spatiotemporal Multi-omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease

(2018) Florian Schlotter et al.   CIRCULATION

MicroRNA-134 Promotes the Development of Atherosclerosis Via the ANGPTL4/LPL Pathway in Apolipoprotein E Knockout Mice

(2018) Qiong Ye et al.   Journal of Atherosclerosis and Thrombosis

Proteomic Profiling Exosomes from Vascular Smooth Muscle Cell

(2018) Hong Qiu et al.   Proteomics Clinical Applications

Atherosclerosis is exacerbated by chitinase-3-like-1 in amyloid precursor protein transgenic mice

(2018) Yu Yeon Jung et al.   Theranostics

Inflammatory and metabolic mechanisms underlying the calcific aortic valve disease

(2018) Kyoung Im Cho et al.   ATHEROSCLEROSIS

Blockade of NEAT1 represses inflammation response and lipid uptake via modulating miR-342-3p in human macrophages THP-1 cells

(2018) Lei Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Histone deacetylase 6 reduction promotes aortic valve calcification via an endoplasmic reticulum stress-mediated osteogenic pathway

(2018) Zurong Fu et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Calcific aortic valve stenosis: hard disease in the heart

(2017) Frederique E C M Peeters et al.   EUROPEAN HEART JOURNAL

Exosomes: Therapy delivery tools and biomarkers of diseases

(2017) Lucio Barile et al.   PHARMACOLOGY & THERAPEUTICS

Targeting vasoactive peptides for managing calcific aortic valve disease

(2016) Tuomas Peltonen et al.   ANNALS OF MEDICINE

Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2 -mediated stress signaling

(2016) C. X. Santos et al.   EMBO JOURNAL

Roles of exosomes in cardioprotection

(2016) Lucio Barile et al.   EUROPEAN HEART JOURNAL

Emerging roles for vascular smooth muscle cell exosomes in calcification and coagulation

(2016) A. N. Kapustin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Therapeutic potential of intermittent hypoxia: a matter of dose

(2014) Angela Navarrete-Opazo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Expression of smooth muscle cell markers and co-activators in calcified aortic valves

(2014) Najma Latif et al.   EUROPEAN HEART JOURNAL

Potential drug targets for calcific aortic valve disease

(2014) Joshua D. Hutcheson et al.   Nature Reviews Cardiology

PERK‐eIF2α‐ATF4‐CHOP Signaling Contributes to TNFα‐Induced Vascular Calcification

(2013) Masashi Masuda et al.   Journal of the American Heart Association

Integrated Stress Response Modulates Cellular Redox State via Induction of Cystathionine γ-Lyase

(2012) Jeffrey G. Dickhout et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activating transcription factor 4 regulates stearate-induced vascular calcification

(2012) Masashi Masuda et al.   JOURNAL OF LIPID RESEARCH

Overexpression of CXCL16 promotes a vulnerable plaque phenotype in Apolipoprotein E–Knockout Mice

(2010) Gui-wen Yi et al.   CYTOKINE

NAD+ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

(2010) C. C. Alano et al.   JOURNAL OF NEUROSCIENCE