Comprehensive Search for GPCR Compounds which Can Enhance MafA and/or PDX-1 Expression Levels Using a Small Molecule Compound Library

GPCR systems pharmacology: a different perspective on the development of biased therapeutics

(2022) Dylan Scott Eiger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Translating the force—mechano-sensing GPCRs

(2022) Caroline Wilde et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

G protein-coupled receptors as regulators of pancreatic islet functionality

(2022) Doreen Thor   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular Mechanism of Pancreatic β-Cell Failure in Type 2 Diabetes Mellitus

(2022) Hideaki Kaneto et al.   Biomedicines

Cell Cycle Regulation of the Pdx1 Transcription Factor in Developing Pancreas and Insulin-Producing β Cells

(2021) Xiaogdong Zhu et al.   DIABETES

PDX1LOW MAFALOW β-cells contribute to islet function and insulin release

(2021) Daniela Nasteska et al.   Nature Communications

Glucolipotoxicity and GLP-1 secretion

(2021) Jung-Hee Hong et al.   BMJ Open Diabetes Research & Care

Early combination therapy of empagliflozin and linagliptin exerts beneficial effects on pancreatic β cells in diabetic db/db mice

(2021) Yoshiro Fushimi et al.   Scientific Reports

MafA, NeuroD1, and HNF1β synergistically activate the Slc2a2 (Glut2) gene in β-cells

(2021) Yuka Ono et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The β-cell glucose toxicity hypothesis: Attractive but difficult to prove

(2021) Gordon C. Weir et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Transcription factors that shape the mammalian pancreas

(2020) Rachel E. Jennings et al.   DIABETOLOGIA

Notable Underlying Mechanism for Pancreatic β-Cell Dysfunction and Atherosclerosis: Pleiotropic Roles of Incretin and Insulin Signaling

(2020) Hideaki Kaneto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice

(2019) Atsushi Obata et al.   DIABETOLOGIA

Loss of MafA and MafB expression promotes islet inflammation

(2019) Tania Singh et al.   Scientific Reports

Glucolipotoxicity Alters Insulin Secretion via Epigenetic Changes in Human Islets

(2019) Elin Hall et al.   DIABETES

Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes

(2019) Maria Lytrivi et al.   JOURNAL OF MOLECULAR BIOLOGY

Protective effects of the SGLT2 inhibitor luseogliflozin on pancreatic β-cells in db/db mice: The earlier and longer, the better

(2018) Tomohiko Kimura et al.   DIABETES OBESITY & METABOLISM

Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes

(2018) Brandon B. Boland et al.   DIABETES

PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regeneration

(2017) Yaxi Zhu et al.   Stem Cell Research & Therapy

Development of novel ligands for peptide GPCRs

(2016) Brian M Moran et al.   CURRENT OPINION IN PHARMACOLOGY

Impact of Pdx1-associated chromatin modifiers on islet β-cells

(2016) J. M. Spaeth et al.   DIABETES OBESITY & METABOLISM

Glucose and GTP-binding protein-coupled receptor cooperatively regulate transient receptor potential-channels to stimulate insulin secretion [Review]

(2016) Masafumi Kakei et al.   ENDOCRINE JOURNAL

Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function

(2015) Cristina Alarcon et al.   DIABETES

Preserving Mafa Expression in Diabetic Islet β-Cells Improves Glycemic Controlin Vivo

(2015) Taka-aki Matsuoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective effects of pioglitazone and/or liraglutide on pancreatic β-cells in db/db mice: Comparison of their effects between in an early and advanced stage of diabetes

(2015) Tomohiko Kimura et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Appropriate therapy for type 2 diabetes mellitus in view of pancreatic β-cell glucose toxicity: “the earlier, the better”

(2015) Hideaki Kaneto et al.   Journal of Diabetes

β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment

(2014) Philippe A. Halban et al.   DIABETES CARE

Free Fatty Acids-Sensing G Protein-Coupled Receptors in Drug Targeting and Therapeutics

(2013) Tomo Yonezawa et al.   CURRENT MEDICINAL CHEMISTRY

A Novel Function of Onecut1 Protein as a Negative Regulator ofMafAGene Expression

(2013) Kaoru Yamamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes

(2011) M. Shimoda et al.   DIABETOLOGIA

Regulation of MafA Expression in Pancreatic  -Cells in db/db Mice With Diabetes

(2010) T.-a. Matsuoka et al.   DIABETES

The Year In G Protein-Coupled Receptor Research

(2009) Robert P. Millar et al.   MOLECULAR ENDOCRINOLOGY