The β-cell glucose toxicity hypothesis: Attractive but difficult to prove

Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes

(2021) Sharona Tornovsky-Babeay et al.   DIABETOLOGIA

Time Course of Normalization of Functional β-Cell Capacity in the Diabetes Remission Clinical Trial After Weight Loss in Type 2 Diabetes

(2020) Sviatlana V. Zhyzhneuskaya et al.   DIABETES CARE

Inadequate β-cell mass is essential for the pathogenesis of type 2 diabetes

(2020) Gordon C Weir et al.   Lancet Diabetes & Endocrinology

Beta cell identity changes with mild hyperglycemia: Implications for function, growth, and vulnerability

(2020) Aref G. Ebrahimi et al.   Molecular Metabolism

A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion

(2020) Aharon Helman et al.   Cell Metabolism

HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of islet β-Cells from Donors with Type 1 Diabetes

(2019) Mark A. Russell et al.   DIABETES

Palmitate is not an effective fuel for pancreatic islets and amplifies insulin secretion independent of calcium release from endoplasmic reticulum

(2019) Iok Teng Kuok et al.   Islets

Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes

(2019) Cristina Aguayo-Mazzucato et al.   Cell Metabolism

Hypoxia signaling in human diseases and therapeutic targets

(2019) Jae W. Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function

(2019) Chiara Montemurro et al.   Nature Communications

Proinsulin misfolding is an early event in the progression to type 2 diabetes

(2019) Anoop Arunagiri et al.   eLife

Glucolipotoxicity, β-Cells, and Diabetes: The Emperor Has No Clothes

(2019) Gordon C. Weir   DIABETES

Activation of the HIF1α/PFKFB3 stress response pathway in beta cells in type 1 diabetes

(2019) Hiroshi Nomoto et al.   DIABETOLOGIA

Changing the landscape for type 1 diabetes: the first step to prevention

(2019) Colin M Dayan et al.   LANCET

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

(2018) Emma Ahlqvist et al.   Lancet Diabetes & Endocrinology

Biosynthesis, structure, and folding of the insulin precursor protein

(2018) Ming Liu et al.   DIABETES OBESITY & METABOLISM

Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions

(2017) Mohammed Bensellam et al.   JOURNAL OF ENDOCRINOLOGY

Glucose Driven Changes in Beta Cell Identity Are Important for Function and Possibly Autoimmune Vulnerability during the Progression of Type 1 Diabetes

(2017) Gordon C. Weir et al.   Frontiers in Genetics

SerpinB1 Promotes Pancreatic β Cell Proliferation

(2016) Abdelfattah El Ouaamari et al.   Cell Metabolism

Standardized Mixed-Meal Tolerance and Arginine Stimulation Tests Provide Reproducible and Complementary Measures of β-Cell Function: Results From the Foundation for the National Institutes of Health Biomarkers Consortium Investigative Series

(2016) Sudha S. Shankar et al.   DIABETES CARE

Dynamics of glucose-induced insulin secretion in normal human islets

(2015) Jean-Claude Henquin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function

(2015) Cristina Alarcon et al.   DIABETES

β Cell death and dysfunction during type 1 diabetes development in at-risk individuals

(2015) Kevan C. Herold et al.   JOURNAL OF CLINICAL INVESTIGATION

Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells

(2015) Mourad Ferdaoussi et al.   JOURNAL OF CLINICAL INVESTIGATION

Reduced Ki67 Staining in the Postmortem State Calls Into Question Past Conclusions About the Lack of Turnover of Adult Human β-Cells

(2014) Brooke A. Sullivan et al.   DIABETES

β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment

(2014) Philippe A. Halban et al.   DIABETES CARE

Islet β cell mass in diabetes and how it relates to function, birth, and death

(2013) Gordon C. Weir et al.   Annals of the New York Academy of Sciences

RETRACTED: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation

(2013) Peng Yi et al.   CELL

Birth and Death of Human β-Cells in Pancreases from Cadaver Donors, Autopsies, Surgical Specimens, and Islets Transplanted into Mice

(2013) Francisco Caballero et al.   CELL TRANSPLANTATION

Acceleration of the Loss of the First-Phase Insulin Response During the Progression to Type 1 Diabetes in Diabetes Prevention Trial-Type 1 Participants

(2013) J. M. Sosenko et al.   DIABETES

The diagnosis of insulitis in human type 1 diabetes

(2013) M. L. Campbell-Thompson et al.   DIABETOLOGIA

Inactivation of specific β cell transcription factors in type 2 diabetes

(2013) Shuangli Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Diabetes Mellitus and the β Cell: The Last Ten Years

(2012) Frances M. Ashcroft et al.   CELL

 -Cell Mass and Turnover in Humans: Effects of obesity and aging

(2012) Y. Saisho et al.   DIABETES CARE

Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase Modulates Oscillations of Pancreatic Islet Metabolism

(2012) Matthew J. Merrins et al.   PLoS One

Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics

(2011) Nicolai M. Doliba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Control of Pancreatic β Cell Regeneration by Glucose Metabolism

(2011) Shay Porat et al.   Cell Metabolism

A Low-Oxygenated Subpopulation of Pancreatic Islets Constitutes a Functional Reserve of Endocrine Cells

(2011) R. Olsson et al.   DIABETES

Quantitative analysis of cell composition and purity of human pancreatic islet preparations

(2010) Anna Pisania et al.   LABORATORY INVESTIGATION

Regulation of insulin secretion: a matter of phase control and amplitude modulation

(2009) J. C. Henquin   DIABETOLOGIA

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation

(2009) M. Cnop et al.   DIABETOLOGIA

C-Peptide Levels and Insulin Independence Following Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus

(2009) Carlos E. B. Couri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study

(2009) Adam G Tabák et al.   LANCET

First-Phase Insulin Secretion Restoration and Differential Response to Glucose Load Depending on the Route of Administration in Type 2 Diabetic Subjects After Bariatric Surgery

(2008) S. Salinari et al.   DIABETES CARE

Relationship between β-cell mass and diabetes onset

(2008) A. V. Matveyenko et al.   DIABETES OBESITY & METABOLISM

Pancreatic β-cell mass in European subjects with type 2 diabetes

(2008) J. Rahier et al.   DIABETES OBESITY & METABOLISM

Metabolic consequences of a 50% partial pancreatectomy in humans

(2008) B. A. Menge et al.   DIABETOLOGIA