Appropriate therapy for type 2 diabetes mellitus in view of pancreatic β-cell glucose toxicity: “the earlier, the better”

Role of Pancreatic Transcription Factors in Maintenance of Mature β-Cell Function

(2015) Hideaki Kaneto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Preserving Mafa Expression in Diabetic Islet β-Cells Improves Glycemic Controlin Vivo

(2015) Taka-aki Matsuoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective effects of pioglitazone and/or liraglutide on pancreatic β-cells in db/db mice: Comparison of their effects between in an early and advanced stage of diabetes

(2015) Tomohiko Kimura et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy

(2014) Zhiyu Wang et al.   Cell Metabolism

Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass

(2014) Ryan K. Mitchell et al.   HUMAN MOLECULAR GENETICS

Clinical Evidence for the Earlier Initiation of Insulin Therapy in Type 2 Diabetes

(2013) David R. Owens   Diabetes Technology & Therapeutics

TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass

(2013) Iseki Takamoto et al.   DIABETOLOGIA

Inactivation of specific β cell transcription factors in type 2 diabetes

(2013) Shuangli Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Diabetes Risk Gene and Wnt Effector Tcf7l2/TCF4 Controls Hepatic Response to Perinatal and Adult Metabolic Demand

(2012) Sylvia F. Boj et al.   CELL

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Vildagliptin preserves the mass and function of pancreatic β cells via the developmental regulation and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes

(2012) S. Hamamoto et al.   DIABETES OBESITY & METABOLISM

The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes

(2011) M. Shimoda et al.   DIABETOLOGIA

Effect of alogliptin, pioglitazone and glargine on pancreatic β-cells in diabetic db/db mice

(2010) Satoshi Kawashima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of MafA Expression in Pancreatic  -Cells in db/db Mice With Diabetes

(2010) T.-a. Matsuoka et al.   DIABETES

Molecular mechanism by which pioglitazone preserves pancreatic β-cells in obese diabetic mice: evidence for acute and chronic actions as a PPARγ agonist

(2009) Yukiko Kanda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

TCF7L2 Variant rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Action

(2009) D. T. Villareal et al.   DIABETES

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

(2009) Luan Shu et al.   HUMAN MOLECULAR GENETICS

Glucagon-like Peptide-1 Activation of TCF7L2-dependent Wnt Signaling Enhances Pancreatic Beta Cell Proliferation

(2008) Zhengyu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of intensive insulin therapy on β-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial

(2008) Jianping Weng et al.   LANCET