A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescence

Age-associated differences in the human lung extracellular matrix

(2023) Maunick Lefin Koloko Ngassie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A Novel Regulatory Role of ALCAM in the Pathogenesis of Pulmonary Fibrosis

(2022) Mi Na Kim et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The functions and roles of sestrins in regulating human diseases

(2022) Yitong Chen et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice

(2022) Barbara Spix et al.   Nature Communications

How collagen becomes ‘stiff’

(2022) Rebecca G Wells   eLife

Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis

(2022) Christopher J Brereton et al.   eLife

IL7R Is Correlated With Immune Cell Infiltration in the Tumor Microenvironment of Lung Adenocarcinoma

(2022) Xin Wang et al.   Frontiers in Pharmacology

Cadherin-11 and its role in tissue fibrosis

(2022) Thandiwe Chavula et al.   CELLS TISSUES ORGANS

Urinary CC16, a potential indicator of lung integrity and inflammation, increases in children after short-term exposure to PM2.5/PM10 and is driven by the CC16 38GG genotype

(2022) Sarah J.D. Nauwelaerts et al.   ENVIRONMENTAL RESEARCH

Cellular senescence is a key mediator of lung aging and susceptibility to infection

(2022) Blake L. Torrance et al.   Frontiers in Immunology

Cytokine Regulation and Function in T Cells

(2021) Chen Dong   Annual Review of Immunology

Macrophage function in the elderly and impact on injury repair and cancer

(2021) L Duong et al.   Immunity & Ageing

BET proteins are associated with the induction of small airway fibrosis in COPD

(2021) Razia Zakarya et al.   THORAX

Transcriptomic profile of the mice aging lung is associated with inflammation and apoptosis as important pathways

(2021) Jazmin Calyeca et al.   Aging-US

The aging lung: Physiology, disease, and immunity

(2021) Jaime L. Schneider et al.   CELL

Age-dependent alveolar epithelial plasticity orchestrates lung homeostasis and regeneration

(2021) Ian J. Penkala et al.   Cell Stem Cell

The Ferroxidase Hephaestin in Lung Cancer: Pathological Significance and Prognostic Value

(2021) Paola Zacchi et al.   Frontiers in Oncology

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

(2021) Ruchi Kumari et al.   Frontiers in Cell and Developmental Biology

Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage

(2021) Anna Barkaway et al.   IMMUNITY

Aging increases senescence, calcium signaling, and extracellular matrix deposition in human airway smooth muscle

(2021) Sarah A. Wicher et al.   PLoS One

Gene 33/Mig6/ERRFI1, an Adapter Protein with Complex Functions in Cell Biology and Human Diseases

(2021) Dazhong Xu et al.   Cells

Circulating Secretoglobin Family 1A Member 1 (SCGB1A1) Levels as a Marker of Biomass Smoke Induced Chronic Obstructive Pulmonary Disease

(2021) Vivek Vardhan Veerapaneni et al.   Toxics

p53 in senescence – it's a marathon not a sprint

(2021) Eleanor Sheekey et al.   FEBS Journal

Collagen 1a1 Expression by Airway Macrophages Increases In Fibrotic ILDs and Is Associated With FVC Decline and Increased Mortality

(2021) Eliza Tsitoura et al.   Frontiers in Immunology

The role of gene–environment interactions in lung disease: the urgent need for the exposome

(2020) Craig E. Wheelock et al.   EUROPEAN RESPIRATORY JOURNAL

Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis

(2020) Tatsuya Tsukui et al.   Nature Communications

Role of p53 in the Regulation of Cellular Senescence

(2020) Mahmut Mijit et al.   Biomolecules

Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age

(2020) Adiv A. Johnson et al.   AGEING RESEARCH REVIEWS

Vascular dysfunction in aged mice contributes to persistent lung fibrosis

(2020) Nunzia Caporarello et al.   AGING CELL

Multi-omics integrative analysis to access role of coiled-coil domain-containing 80 in lipid metabolism

(2020) Wenyun Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mesothelial cells regulate immune responses in health and disease: role for immunotherapy in malignant mesothelioma

(2020) Steven E Mutsaers et al.   CURRENT OPINION IN IMMUNOLOGY

Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework

(2020) Alan A. Cohen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Distal lung epithelial progenitor cell function declines with age

(2020) Julie K. Watson et al.   Scientific Reports

The G Protein-Coupled Receptor (GPR) 15 Counteracts Antibody-Mediated Skin Inflammation

(2020) Lina Jegodzinski et al.   Frontiers in Immunology

Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis

(2020) Changfu Yao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A guide to plasma membrane solute carrier proteins

(2020) Mattia D. Pizzagalli et al.   FEBS Journal

New Era of Diacylglycerol Kinase, Phosphatidic Acid and Phosphatidic Acid-Binding Protein

(2020) Fumio Sakane et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SIRT1 is downregulated by autophagy in senescence and ageing

(2020) Caiyue Xu et al.   NATURE CELL BIOLOGY

The GTEx Consortium atlas of genetic regulatory effects across human tissues

(2020)   SCIENCE

Sestrin family – the stem controlling healthy ageing

(2020) Alexander Haidurov et al.   MECHANISMS OF AGEING AND DEVELOPMENT

A molecular cell atlas of the human lung from single-cell RNA sequencing

(2020) Kyle J. Travaglini et al.   NATURE

Plasma proteomic biomarker signature of age predicts health and life span

(2020) Toshiko Tanaka et al.   eLife

Microenvironment-related prognostic genes in esophageal cancer

(2020) Min-Hang Zhou et al.   Translational Cancer Research

Upregulated Collagen COL10A1 Remodels the Extracellular Matrix and Promotes Malignant Progression in Lung Adenocarcinoma

(2020) Yingkuan Liang et al.   Frontiers in Oncology

Quantitative proteomic characterization of lung tissue in idiopathic pulmonary fibrosis

(2019) Yaqiong Tian et al.   Clinical Proteomics

An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics

(2019) Ilias Angelidis et al.   Nature Communications

The Aging Lung and Idiopathic Pulmonary Fibrosis

(2019) Swati Gulati et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Regulation of death receptor signaling by the autophagy protein TP53INP2

(2019) Saška Ivanova et al.   EMBO JOURNAL

Autophagy and senescence: A new insight in selected human diseases

(2019) Peramaiyan Rajendran et al.   JOURNAL OF CELLULAR PHYSIOLOGY

g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)

(2019) Uku Raudvere et al.   NUCLEIC ACIDS RESEARCH

Cellular Senescence: Aging, Cancer, and Injury

(2019) Arianna Calcinotto et al.   PHYSIOLOGICAL REVIEWS

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Editorial: Alveolar Macrophages in Lung Inflammation and Resolution

(2019) Guochang Hu et al.   Frontiers in Immunology

Aging and Lung Disease

(2019) Soo Jung Cho et al.   Annual Review of Physiology

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

SIRT1/PGC-1 pathway activation triggers autophagy/mitophagy and attenuates oxidative damage in intestinal epithelial cells

(2019) Danyang Liang et al.   BIOCHIMIE

Patterns of Aging Biomarkers, Mortality, and Damaging Mutations Illuminate the Beginning of Aging and Causes of Early-Life Mortality

(2019) Elvira D. Kinzina et al.   Cell Reports

Age-Related Structural and Functional Changes in the Mouse Lung

(2019) Henri Schulte et al.   Frontiers in Physiology

More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis

(2019) Martha Gschwandtner et al.   Frontiers in Immunology

Aging and anatomical variations in lung tissue stiffness

(2018) Delphine Sicard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Inhibition of Radiation-Induced Ccl2 Signaling Protects Lungs from Vascular Dysfunction and Endothelial Cell Loss

(2018) Alina Wiesemann et al.   ANTIOXIDANTS & REDOX SIGNALING

Odd-skipped related 1 inhibits lung cancer proliferation and invasion by reducing Wnt signaling through the suppression of SOX9 and β-catenin

(2018) Yuan Wang et al.   CANCER SCIENCE

Mapping the Mouse Cell Atlas by Microwell-Seq

(2018) Xiaoping Han et al.   CELL

Collagen degradation and formation are elevated in exacerbated COPD compared to stable disease

(2018) Desiree M. Schumann et al.   CHEST

Mucins, Mucus, and Goblet Cells

(2018) Jonathan Ma et al.   CHEST

Spatial-Temporal Lineage Restrictions of Embryonic p63 + Progenitors Establish Distinct Stem Cell Pools in Adult Airways

(2018) Ying Yang et al.   DEVELOPMENTAL CELL

Elastin in lung development and disease pathogenesis

(2018) Robert P. Mecham   MATRIX BIOLOGY

Emerging role of extracellular vesicles as a senescence-associated secretory phenotype: Insights into the pathophysiology of lung diseases

(2018) Tsukasa Kadota et al.   MOLECULAR ASPECTS OF MEDICINE

Pulmonary alveolar proteinosis in adults: pathophysiology and clinical approach

(2018) Anupam Kumar et al.   Lancet Respiratory Medicine

S100a4 Is Secreted by Alternatively Activated Alveolar Macrophages and Promotes Activation of Lung Fibroblasts in Pulmonary Fibrosis

(2018) Wei Zhang et al.   Frontiers in Immunology

IGF-Binding Proteins: Why Do They Exist and Why Are There So Many?

(2018) John B. Allard et al.   Frontiers in Endocrinology

Lung injury and fibrosis induced by a mutant form of surfactant protein C

(2018) Timothy S. Blackwell   JOURNAL OF CLINICAL INVESTIGATION

A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte

(2018) Lindsey W. Plasschaert et al.   NATURE

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

(2018) Claudio Franceschi et al.   Nature Reviews Endocrinology

OUP accepted manuscript

(2018)   NUCLEIC ACIDS RESEARCH

Fibulin-2 is required for basement membrane integrity of mammary epithelium

(2018) Ayman M. Ibrahim et al.   Scientific Reports

S100A4+ Macrophages Are Necessary for Pulmonary Fibrosis by Activating Lung Fibroblasts

(2018) Yanan Li et al.   Frontiers in Immunology

The micromechanics of lung alveoli: structure and function of surfactant and tissue components

(2018) Lars Knudsen et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Class II MHC antigen processing in immune tolerance and inflammation

(2018) Mollie M. Jurewicz et al.   IMMUNOGENETICS

Linking cellular stress responses to systemic homeostasis

(2018) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interstitial Lung Disease and Pulmonary Fibrosis: A Practical Approach for General Medicine Physicians with Focus on the Medical History

(2018) Or Kalchiem-Dekel et al.   Journal of Clinical Medicine

The instructive extracellular matrix of the lung: basic composition and alterations in chronic lung disease

(2017) Gerald Burgstaller et al.   EUROPEAN RESPIRATORY JOURNAL

Cutting Edge: CD3 ITAM Diversity Is Required for Optimal TCR Signaling and Thymocyte Development

(2017) Matthew L. Bettini et al.   JOURNAL OF IMMUNOLOGY

Aging Impairs Alveolar Macrophage Phagocytosis and Increases Influenza-Induced Mortality in Mice

(2017) Christine K. Wong et al.   JOURNAL OF IMMUNOLOGY

Thy-1 interaction with Fas in lipid rafts regulates fibroblast apoptosis and lung injury resolution

(2017) Xiaoqiu Liu et al.   LABORATORY INVESTIGATION

A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45

(2017) Adam H. Courtney et al.   MOLECULAR CELL

Census and evaluation of p53 target genes

(2017) M Fischer   ONCOGENE

Ethanolamine and Phosphatidylethanolamine: Partners in Health and Disease

(2017) Dhaval Patel et al.   Oxidative Medicine and Cellular Longevity

Lung tissue gene-expression signature for the ageing lung in COPD

(2017) Maaike de Vries et al.   THORAX

TNF-α-induced LRG1 promotes angiogenesis and mesenchymal stem cell migration in the subchondral bone during osteoarthritis

(2017) Yiyun Wang et al.   Cell Death & Disease

Cathepsin-S degraded decorin are elevated in fibrotic lung disorders – development and biological validation of a new serum biomarker

(2017) S.N. Kehlet et al.   BMC Pulmonary Medicine

Telomeres and Cell Senescence - Size Matters Not

(2017) Stella Victorelli et al.   EBioMedicine

Galectin-3 Is Associated with Restrictive Lung Disease and Interstitial Lung Abnormalities

(2016) Jennifer E. Ho et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Type V Collagen in Health, Disease, and Fibrosis

(2016) Ki M. Mak et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Lung surfactant: Function and composition in the context of development and respiratory physiology

(2016) Wolfgang Bernhard   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Senescence-Associated MCP-1 Secretion Is Dependent on a Decline in BMI1 in Human Mesenchymal Stromal Cells

(2016) Hye Jin Jin et al.   ANTIOXIDANTS & REDOX SIGNALING

Lgr5 regulates the regeneration of lesioned nasal respiratory epithelium

(2016) Yan-Qiang Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The biology of the ABCA3 lipid transporter in lung health and disease

(2016) Michael F. Beers et al.   CELL AND TISSUE RESEARCH

Mechanisms of lung aging

(2016) Christina Brandenberger et al.   CELL AND TISSUE RESEARCH

Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis

(2016) Xiaofang Sun et al.   HEPATOLOGY

Comparative genomics of the human, macaque and mouse major histocompatibility complex

(2016) Takashi Shiina et al.   IMMUNOLOGY

Tenascin-C at a glance

(2016) Kim S. Midwood et al.   JOURNAL OF CELL SCIENCE

Decreased Laminin Expression by Human Lung Epithelial Cells and Fibroblasts Cultured in Acellular Lung Scaffolds from Aged Mice

(2016) Lindsay M. Godin et al.   PLoS One

Pulmonary Macrophages: A New Therapeutic Pathway in Fibrosing Lung Disease?

(2016) Adam J. Byrne et al.   TRENDS IN MOLECULAR MEDICINE

Clinical Association of Chemokine (C-X-C motif) Ligand 1 (CXCL1) with Interstitial Pneumonia with Autoimmune Features (IPAF)

(2016) Minrui Liang et al.   Scientific Reports

Comparative Transcriptome Analysis Identifies CCDC80 as a Novel Gene Associated with Pulmonary Arterial Hypertension

(2016) Shota Sasagawa et al.   Frontiers in Pharmacology

Characterization of spontaneous air space enlargement in mice lacking microfibrillar-associated protein 4

(2015) Anne Trommelholt Holm et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams

(2015) Henry Heberle et al.   BMC BIOINFORMATICS

Phosphatidylethanolamine positively regulates autophagy and longevity

(2015) P Rockenfeller et al.   CELL DEATH AND DIFFERENTIATION

The development and plasticity of alveolar type 1 cells

(2015) Jun Yang et al.   DEVELOPMENT

The MS4A family: counting past 1, 2 and 3

(2015) Li Eon Kuek et al.   IMMUNOLOGY AND CELL BIOLOGY

Rac1-dependent secretion of platelet-derived CCL5 regulates neutrophil recruitment via activation of alveolar macrophages in septic lung injury

(2015) Rundk Hwaiz et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The microfibril-associated glycoproteins (MAGPs) and the microfibrillar niche

(2015) Robert P. Mecham et al.   MATRIX BIOLOGY

Time- and compartment-resolved proteome profiling of the extracellular niche in lung injury and repair

(2015) H. B. Schiller et al.   Molecular Systems Biology

Respiratory epithelial cells orchestrate pulmonary innate immunity

(2015) Jeffrey A Whitsett et al.   NATURE IMMUNOLOGY

BioGPS: building your own mash-up of gene annotations and expression profiles

(2015) Chunlei Wu et al.   NUCLEIC ACIDS RESEARCH

‘LungGENS’: a web-based tool for mapping single-cell gene expression in the developing lung: Figure 1

(2015) Yina Du et al.   THORAX

Pulmonary macrophages: key players in the innate defence of the airways

(2015) Adam J Byrne et al.   THORAX

Senescence-associated inflammatory responses: aging and cancer perspectives

(2015) Audrey Lasry et al.   TRENDS IN IMMUNOLOGY

Extracellular matrix biomimicry for the creation of investigational and therapeutic devices

(2015) Amanda S. Pellowe et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Clonal Dynamics Reveal Two Distinct Populations of Basal Cells in Slow-Turnover Airway Epithelium

(2015) Julie K. Watson et al.   Cell Reports

Eotaxin-1 (CCL11)

(2015) Timothy John Williams   Frontiers in Immunology

Molecular composition of the alveolar lining fluid in the aging lung

(2014) Juan I. Moliva et al.   AGE

C-X-C Motif Chemokine 13 (CXCL13) Is a Prognostic Biomarker of Idiopathic Pulmonary Fibrosis

(2014) Louis J. Vuga et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Senescence-Associated Secretory Phenotype and Its Possible Role in Chronic Obstructive Pulmonary Disease

(2014) Manish Kumar et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Repair and Regeneration of the Respiratory System: Complexity, Plasticity, and Mechanisms of Lung Stem Cell Function

(2014) Brigid L.M. Hogan et al.   Cell Stem Cell

Dynamic Changes in Intracellular ROS Levels Regulate Airway Basal Stem Cell Homeostasis through Nrf2-Dependent Notch Signaling

(2014) Manash K. Paul et al.   Cell Stem Cell

Induction of galectin-1 by TGF-β1 accelerates fibrosis through enhancing nuclear retention of Smad2

(2014) Min Jin Lim et al.   EXPERIMENTAL CELL RESEARCH

Versican and the control of inflammation

(2014) Thomas N. Wight et al.   MATRIX BIOLOGY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Age-Related Changes in the Cellular Composition and Epithelial Organization of the Mouse Trachea

(2014) Carolien Wansleeben et al.   PLoS One

Fibroblasts secrete Slit2 to inhibit fibrocyte differentiation and fibrosis

(2014) Darrell Pilling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunosurveillance of senescent cells: the bright side of the senescence program

(2013) Adi Sagiv et al.   BIOGERONTOLOGY

Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation

(2013) K. De Filippo et al.   BLOOD

Redox regulation of SIRT1 in inflammation and cellular senescence

(2013) Jae-woong Hwang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Microfibril-associated Glycoprotein 2 (MAGP2) Loss of Function Has Pleiotropic Effectsin Vivo

(2013) Michelle D. Combs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aortic Carboxypeptidase-like Protein (ACLP) Enhances Lung Myofibroblast Differentiation through Transforming Growth Factor β Receptor-dependent and -independent Pathways

(2013) Kathleen E. Tumelty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Group V Secretory Phospholipase A2 Is Involved in Macrophage Activation and Is Sufficient for Macrophage Effector Functions in Allergic Pulmonary Inflammation

(2013) S. Ohta et al.   JOURNAL OF IMMUNOLOGY

LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling

(2013) Xiaomeng Wang et al.   NATURE

Key Role of Group V Secreted Phospholipase A2 in Th2 Cytokine and Dendritic Cell-Driven Airway Hyperresponsiveness and Remodeling

(2013) William R. Henderson Jr et al.   PLoS One

GPR15-Mediated Homing Controls Immune Homeostasis in the Large Intestine Mucosa

(2013) S. V. Kim et al.   SCIENCE

Identification of ovarian cancer driver genes by using module network integration of multi-omics data

(2013) O. Gevaert et al.   Interface Focus

Lgr5-Expressing Cells Are Sufficient and Necessary for Postnatal Mammary Gland Organogenesis

(2013) Vicki Plaks et al.   Cell Reports

Acellular Normal and Fibrotic Human Lung Matrices as a Culture System forIn VitroInvestigation

(2012) Adam J. Booth et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The role of telomere shortening in somatic stem cells and tissue aging: lessons from telomerase model systems

(2012) Stefan Tümpel et al.   Annals of the New York Academy of Sciences

Surfactant phospholipid metabolism

(2012) Marianna Agassandian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Collagen triple helix repeat containing-1 promotes pancreatic cancer progression by regulating migration and adhesion of tumor cells

(2012) Eun Hye Park et al.   CARCINOGENESIS

Loss of Coiled-Coil Domain Containing 80 Negatively Modulates Glucose Homeostasis in Diet-Induced Obese Mice

(2012) Frédéric Tremblay et al.   ENDOCRINOLOGY

Nicotinamide nucleotide transhydrogenase (NNT) acts as a novel modulator of macrophage inflammatory responses

(2012) Vera M. Ripoll et al.   FASEB JOURNAL

The myofibroblast matrix: implications for tissue repair and fibrosis

(2012) Franco Klingberg et al.   JOURNAL OF PATHOLOGY

How the TCR balances sensitivity and specificity for the recognition of self and pathogens

(2012) Gerald P Morris et al.   NATURE IMMUNOLOGY

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Reticular basement membrane in asthma and COPD: Similar thickness, yet different composition

(2012) NH ten Hacken   International Journal of Chronic Obstructive Pulmonary Disease

Notch-Dependent Differentiation of Adult Airway Basal Stem Cells

(2011) Jason R. Rock et al.   Cell Stem Cell

The NLRP3/ASC/Caspase-1 axis regulates IL-1β processing in neutrophils

(2011) Arun K. Mankan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Deletion of the murine scavenger receptor CD68

(2011) Li Song et al.   JOURNAL OF LIPID RESEARCH

Insulin-like growth factor binding protein-6 delays replicative senescence of human fibroblasts

(2011) Lucia Micutkova et al.   MECHANISMS OF AGEING AND DEVELOPMENT

SIRT1 as a therapeutic target in inflammaging of the pulmonary disease

(2011) Irfan Rahman et al.   PREVENTIVE MEDICINE

Peroxisome proliferator-activated receptor-  coactivator 1-  (PGC1 ) is a metabolic regulator of intestinal epithelial cell fate

(2011) I. D'Errico et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

The impact of acetylation and deacetylation on the p53 pathway

(2011) Christopher L. Brooks et al.   Protein & Cell

Proteoglycans: Key Regulators of Pulmonary Inflammation and the Innate Immune Response to Lung Infection

(2010) Sean Gill et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins.

(2010) Krzysztof Pawlowski et al.   BMC GENOMICS

Carbon dioxide is largely responsible for the acute inflammatory effects of tobacco smoke

(2010) Laurent Schwartz et al.   INHALATION TOXICOLOGY

The extracellular matrix at a glance

(2010) C. Frantz et al.   JOURNAL OF CELL SCIENCE

Airway Mucus Function and Dysfunction

(2010) John V. Fahy et al.   NEW ENGLAND JOURNAL OF MEDICINE

SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence

(2010) Limin Han et al.   NUCLEIC ACIDS RESEARCH

The Role of Immunity and Inflammation in Lung Senescence and Susceptibility to Infection in the Elderly

(2010) Keith Meyer   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

ZAP-70: An Essential Kinase in T-cell Signaling

(2010) H. Wang et al.   Cold Spring Harbor Perspectives in Biology

Stereological Estimates of Alveolar Number and Size and Capillary Length and Surface Area in Mice Lungs

(2009) Juliane Knust et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Identification of SULF2 as a Novel Transcriptional Target of p53 by Use of Integrated Genomic Analyses

(2009) B. Nelson Chau et al.   CANCER RESEARCH

Matrix Metalloproteinase 12 Overexpression in Lung Epithelial Cells Plays a Key Role in Emphysema to Lung Bronchioalveolar Adenocarcinoma Transition

(2009) P. Qu et al.   CANCER RESEARCH

The KDEL receptor: New functions for an old protein

(2009) Mirco Capitani et al.   FEBS LETTERS

Organization of proximal signal initiation at the TCR:CD3 complex

(2009) Clifford S. Guy et al.   IMMUNOLOGICAL REVIEWS

The regulation of inflammation by galectin-3

(2009) Neil C. Henderson et al.   IMMUNOLOGICAL REVIEWS

SIRT1 Controls the Transcription of the Peroxisome Proliferator-activated Receptor-γ Co-activator-1α (PGC-1α) Gene in Skeletal Muscle through the PGC-1α Autoregulatory Loop and Interaction with MyoD

(2009) Ramon Amat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MS4A4B Is a GITR-Associated Membrane Adapter, Expressed by Regulatory T Cells, Which Modulates T Cell Activation

(2009) D. Howie et al.   JOURNAL OF IMMUNOLOGY

Matrix Metalloproteinase-8 Inactivates Macrophage Inflammatory Protein-1  To Reduce Acute Lung Inflammation and Injury in Mice

(2009) P. A. Quintero et al.   JOURNAL OF IMMUNOLOGY

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Lung Parenchymal Mechanics in Health and Disease

(2009) Débora S. Faffe et al.   PHYSIOLOGICAL REVIEWS

Interactions between extracellular matrix and growth factors in wound healing

(2009) Gregory S. Schultz et al.   WOUND REPAIR AND REGENERATION

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Multiple Roles of Phospholipase A2 during Lung Infection and Inflammation

(2008) B. P. Hurley et al.   INFECTION AND IMMUNITY

A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration

(2008) Yuzhen Zhang et al.   NATURE GENETICS

Transcriptome-based systematic identification of extracellular matrix proteins

(2008) R.-i. Manabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY