How the TCR balances sensitivity and specificity for the recognition of self and pathogens

A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers

(2011) Lei Yin et al.   IMMUNITY

Control of central and peripheral tolerance by Aire

(2011) Todd C. Metzger et al.   IMMUNOLOGICAL REVIEWS

Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8+ T cells

(2011) Megan J Palmer et al.   IMMUNOLOGY AND CELL BIOLOGY

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alloreactivity is limited by the endogenous peptide repertoire

(2011) Gerald P. Morris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters

(2011) B. N. Manz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinase suppressor of Ras 1 is required for full ERK activation in thymocytes but not for thymocyte selection

(2010) Erin L. Filbert et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A discrete affinity-driven elevation of ZAP-70 kinase activity initiates negative selection

(2010) Michel Mallaun et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

(2010) Jun Huang et al.   NATURE

TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity

(2010) Johannes B. Huppa et al.   NATURE

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

(2010) Siew Siew Pang et al.   NATURE

Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for  -selection and TCR repertoire formation

(2010) E. Ishikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for a functional sidedness to the   TCR

(2010) M. S. Kuhns et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics of Subsynaptic Vesicles and Surface Microclusters at the Immunological Synapse

(2010) M. A. Purbhoo et al.   Science Signaling

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

Comprehensive assessment of T-cell receptor  -chain diversity in    T cells

(2009) H. S. Robins et al.   BLOOD

The functional network of ion channels in T lymphocytes

(2009) Michael D. Cahalan et al.   IMMUNOLOGICAL REVIEWS

Germline-encoded amino acids in the αβ T-cell receptor control thymic selection

(2009) James P. Scott-Browne et al.   NATURE

An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells

(2009) Wan-Lin Lo et al.   NATURE IMMUNOLOGY

Navigating the network: signaling cross-talk in hematopoietic cells

(2009) Iain D C Fraser et al.   NATURE IMMUNOLOGY

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

(2009) Björn F Lillemeier et al.   NATURE IMMUNOLOGY

The molecular basis of TCR germline bias for MHC is surprisingly simple

(2009) K Christopher Garcia et al.   NATURE IMMUNOLOGY

Themis, a T cell–specific protein important for late thymocyte development

(2009) Renaud Lesourne et al.   NATURE IMMUNOLOGY

Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection

(2009) Andy L Johnson et al.   NATURE IMMUNOLOGY

Themis controls thymocyte selection through regulation of T cell antigen receptor–mediated signaling

(2009) Guo Fu et al.   NATURE IMMUNOLOGY

An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a

(2009) Peter J R Ebert et al.   NATURE IMMUNOLOGY

A Single Peptide-MHC Complex Positively Selects a Diverse and Specific CD8 T Cell Repertoire

(2009) B. Wang et al.   SCIENCE

Cooperativity Between T Cell Receptor Complexes Revealed by Conformational Mutants of CD3 

(2009) N. Martinez-Martin et al.   Science Signaling

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

(2008) Chenqi Xu et al.   CELL

Crossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC Molecules

(2008) Shaodong Dai et al.   IMMUNITY

Spatiotemporal Regulation of T Cell Costimulation by TCR-CD28 Microclusters and Protein Kinase C θ Translocation

(2008) Tadashi Yokosuka et al.   IMMUNITY

Homeostasis of Naive and Memory T Cells

(2008) Charles D. Surh et al.   IMMUNITY

A Two-Step Process for Thymic Regulatory T Cell Development

(2008) Chan-Wang Joaquim Lio et al.   IMMUNITY