Cutting Edge: CD3 ITAM Diversity Is Required for Optimal TCR Signaling and Thymocyte Development

Revisiting Thymic Positive Selection and the Mature T Cell Repertoire for Antigen

(2014) Nienke Vrisekoop et al.   IMMUNITY

Membrane Association of the CD3  Signaling Domain Is Required for Optimal T Cell Development and Function

(2014) M. L. Bettini et al.   JOURNAL OF IMMUNOLOGY

Synthetic biology in mammalian cells: next generation research tools and therapeutics

(2014) Florian Lienert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells

(2013) Clifford S Guy et al.   NATURE IMMUNOLOGY

Generation of T cell receptor–retrogenic mice: improved retroviral-mediated stem cell gene transfer

(2013) Matthew L Bettini et al.   Nature Protocols

Systems Model of T Cell Receptor Proximal Signaling Reveals Emergent Ultrasensitivity

(2013) Himadri Mukhopadhyay et al.   PLoS Computational Biology

Selection of Self-Reactive T Cells in the Thymus

(2012) Gretta L. Stritesky et al.   Annual Review of Immunology

Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain

(2012) Etienne Gagnon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Signaling in thymic selection

(2011) Nicholas RJ Gascoigne et al.   CURRENT OPINION IN IMMUNOLOGY

T-cell receptor affinity in thymic development

(2011) Amy E. Moran et al.   IMMUNOLOGY

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Development of thymically derived natural regulatory T cells

(2010) Matthew L. Bettini et al.   Annals of the New York Academy of Sciences

Organization of proximal signal initiation at the TCR:CD3 complex

(2009) Clifford S. Guy et al.   IMMUNOLOGICAL REVIEWS

Hierarchical role of CD3 chains in thymocyte development

(2009) Vibhuti P. Dave   IMMUNOLOGICAL REVIEWS

The Cytoplasmic Tail of the T Cell Receptor CD3   Subunit Contains a Phospholipid-Binding Motif that Regulates T Cell Functions

(2009) L. M. DeFord-Watts et al.   JOURNAL OF IMMUNOLOGY

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

(2008) Chenqi Xu et al.   CELL

Scalable signaling mediated by T cell antigen receptor–CD3 ITAMs ensures effective negative selection and prevents autoimmunity

(2008) Jeff Holst et al.   NATURE IMMUNOLOGY